Robotic-assisted esophagectomy leads to significant reduction in postoperative acute pain: A retrospective clinical trial

• Conditions: C15; Malignant neoplasm of oesophagus

• Registration Number: DRKS00027859
• Lead Sponsor: niversitätsklinikum Münster

Brief Summary

A total of 274 patients were included. The postoperative opioid consumption rate for patients who underwent RAMIE (quartiles: 0.14, 0.23, 0.36 mg morphine milligram equivalents (MME)/kg body weight (bw)/day) was significantly lower than in the open group (0.19, 0.33, 0.58 mg MME/kg bw/day, p = 0.016). The overall postoperative opioid consumption for patients who underwent RAMIE was significantly lower (2.45, 3.63, 7.20 mg MME/kg bw/day; morphine milligram equivalents per kilogram body weight) compared with the open (4.85, 8.59, 14.63 MME/kg bw/day, p < 0.0001) and hybrid (4.13, 6.84, 11.36 MME/kg bw/day, p = 0.008) groups. Patients who underwent RAMIE reported lower pain scores compared with the open group on the fifth postoperative day, both at rest (p = 0.004) and while performing activities (p < 0.001).

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-12-30
• Study Start: 2022-01-25
• Results First Posted: 2022-07-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 164

Inclusion Criteria

Histologically confirmed thoracic or abdominal esophageal carcinoma,
Surgically resectable at the time of diagnosis or after neoadjuvant treatment,
abdomino-thoracic Icor-Lewis esophagectomy in RAMIE, hybrid or open surgical technique. A retrospective study where all patients were evaluated between 01.01.2012 and 30.12.2021.

Exclusion Criteria

cervical esophageal carcinoma,
carcinoma of the gastroesophageal junction classified Siewert III,
intraoperative termination following diagnostic laparoscopy

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
postoperative analgesic consumption (morphine miligram equivalent)

Secondary Outcome Measures

Name	Time	Method
postoperative pain (NRS pain scale),<br>postoperative hospital stay (days),<br>intensive care unit stay (days), blood loss (ml), complications (Clavien-Dindo classification).