Immunomodulatory Effects of Volatile and Total Intravenous Anesthesia for Patients With Renal Cancer
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- CD 16
研究概览
简要总结
The aim of the study is a comparative study of the cellular immunity response of patients operated on for kidney cancer under total intravenous and inhalational anesthesia.
详细描述
The severity of perioperative immunosuppression is directly proportional to the degree of surgical stress. A series of experimental and clinical studies indicate a different effect of certain types of anesthesia on immunity. It is believed that surgical stress itself opens an opportunity for the recurrence of oncological diseases precisely due to the immunosuppressive effect. The aim of present pilot clinical study is to test a hypothesis that total intravenous anesthesia as superior to inhalational anesthesia in term of its effects on cell immunity among patients with kidney cancer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Surgery for renal cancer
- •Signed informed concent
排除标准
- •Propofol or sevoflurane intolerance
- •Contraindications for epidural anesthesia
- •Renal failure
- •Hepatic failure
- •Congestive heart failure
- •Previous hemotherapy
- •Hematological diseases
研究组 & 干预措施
total intravenous anesthesia
Patients, scheduled for nephrectomy for kidney cancer will receive neuraxial epidural block and propofol for perioperative anesthesia
干预措施: Propofol (Drug)
total intravenous anesthesia
Patients, scheduled for nephrectomy for kidney cancer will receive neuraxial epidural block and propofol for perioperative anesthesia
干预措施: Epidural block (Procedure)
Volatile anesthesia
Patients, scheduled for nephrectomy for kidney cancer will receive neuraxial epidural block and sevoflurane for perioperative anesthesia
干预措施: Sevoflurane (Drug)
Volatile anesthesia
Patients, scheduled for nephrectomy for kidney cancer will receive neuraxial epidural block and sevoflurane for perioperative anesthesia
干预措施: Epidural block (Procedure)
结局指标
主要结局
CD 16
时间窗: postoperative day 1
NK cells expression of CD16 receptor
次要结局
- CD19(Baseline, end of surgery, postoperative days 1, 3-4, 7)
- CD45(Baseline, end of surgery, postoperative days 1, 3-4, 7)
- CD3(Baseline, end of surgery, postoperative days 1, 3-4, 7)
- CD4(Baseline, end of surgery, postoperative days 1, 3-4, 7)
- CD8(Baseline, end of surgery, postoperative days 1, 3-4, 7)
- CD25(Baseline, end of surgery, postoperative days 1, 3-4, 7)
- CD16(Baseline, end of surgery, postoperative days 1, 3-4, 7)
- HLA-DR(Baseline, end of surgery, postoperative days 1, 3-4, 7)
研究者
Efremov Sergey
Principal investigator
Meshalkin Research Institute of Pathology of Circulation