ITMCTR2000002941尚未招募1 期
Study for the Mechanism of Central Analgesia in Patients with Knee Osteoarthritis by Tuina Based on Brain Magnetic Resonance Imaging
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine0 个研究点开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional study
入排标准
- 年龄范围
- 18 至 65（—）
- 性别
- All
入选标准
- •1. KOA chronic pain subjects inclusion criteria
- •(1) Meet the diagnostic criteria of traditional Chinese and Western medicine for knee osteoarthritis;
- •(2) Aged 18 to 65 years old male and female, right-handed;
- •(3) Kellgren-Lawrence radiological score is I-II;
- •(4) Knee joint pain lasts for more than 3 months; VAS score >=3 points;
- •(5) Occupation: non-physical workers (such as teachers, employees of enterprises and institutions, etc.), no violent lower extremity activities;
- •(6) Understand and agree to participate in this study and sign the informed consent.
- •2. Inclusion criteria for asymptomatic KOA subjects
- •(1) Once met the diagnostic criteria of traditional Chinese and Western medicine for knee osteoarthritis;
- •(2) Aged 18 to 65 years old male and female, right-handed;
- •(3) Kellgren-Lawrence radiological score is I-II;
- •(4) Knee joint has no pain in the last 3 months; VAS score = 0;
- •(5) Occupation: Non-physical workers (such as teachers, employees of enterprises and institutions, etc.), no violent lower limb activities in daily life;
- •(6) Understand and agree to participate in this study and sign the informed consent.
- •3. Healthy subjects:
- •(1) Aged 18 to 65 years old male and female;
- •(2) good health;
- •(3) Right-handed.
排除标准
- •KOA chronic pain subjects:
- •1. Take painkillers or anesthetics in the last 1 month;
- •2. who received any other treatment within the last 1 month;
- •3. pregnant or lactating women;
- •4. suffer from mental illness, neurological disease, infectious disease, gastrointestinal disease, cardiovascular and cerebrovascular disease, immunological disease, respiratory disease or kidney disease;
- •5. have tumors, tuberculosis, rheumatism or rheumatoid arthritis, gout, joint trauma, or any other chronic pain symptoms, or have a history of brain trauma with loss of consciousness;
- •6. Patients with MRI contraindications such as atresia, pacemaker, defibrillator, cardiac stent, and intrauterine device;
- •7. Defects or ulcers on the skin around the knee joint;
- •Asymptomatic KOA subjects:
- •1. Patients with MRI contraindications such as atresia, pacemaker, defibrillator, cardiac stent, and intrauterine device;
- •2. Use of antipyretic, analgesic, sleeping or hormone drugs in the last week;
- •3. Pain occurred in the last 1 month;
- •4. History of cardiovascular, cerebrovascular, central nervous system disease, mental illness or head trauma.
研究者
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