Mass Screening of the Population of the North Kynouria Municipality in Arcadia, Greece for the Detection of Cardiovascular and Stroke Risk Factors
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- University Hospital, Ioannina
- Enrollment
- 7,000
- Locations
- 1
- Primary Endpoint
- Emergency room visits
Overview
Brief Summary
The North Kynouria Project was initiated to study cardiovascular/stroke risk factors by employing mass screening and long-term surveillance of an adult population in the municipality of North Kynouria, in the county of Arcadia, Peloponnese, Greece. The North Kynouria Study was initiated to assess modifiable and non-modifiable determinants of cerebrovascular and coronary heart disease.
Detailed Description
BACKGROUND:
The North Kynouria Project is a longitudinal, interventional-behavioural, prospective study aiming to identify cardiovascular/stroke risk factors, in the adult population of the municipality of North Kynouria, in the county of Arcadia, Peloponnese, Greece. The project, initiated in November 2022, recruits volunteers, of both sexes, over 18 years of age, irrespective of their personal history of cardiovascular disease. The epidemiology and burden of cardiovascular disease in North Kynouria remain unknown. The study aims to explore and document the prevalence of major cardiovascular/stroke risk factors, as well as the nutritional status, cigarette smoking, exercise habits, alcohol consumption, and overall quality of life of the inhabitants.
DESIGN NARRATIVE:
The screening exam is conducted at the Astros, Health Center, by obtaining the patient's personal history, and information about the patient's habits, such as physical activity, smoking, and alcohol consumption. Body weight, height, and waist-to-hip ratio are also measured. During the examination, blood pressure is evaluated using a pre-specified protocol, including assessment of orthostatic hypertension. Further testing includes electrocardiography, ankle-brachial index, direct ophthalmoscopy, and carotid and cardiac ultrasound. Blood samples are collected and stored at the deep freeze of the Astros premises, and blood count, lipid panel, and liver and kidney function are measured.
The main field of interest is the prevalence and burden of risk factors and cardiovascular disease in the wider region of North Kynouria, Arcadia Greece. The project aims to assess the epidemiology of CVD and consequently improve public health and engage with the local community through healthy behavioral education.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •residents of North Kynouria
Exclusion Criteria
- •under 18,
- •pregnancy
Outcomes
Primary Outcomes
Emergency room visits
Time Frame: up to 5 years after enrollment
Any cause of emergency room visit
Major adverse cardiovascular events
Time Frame: up to 5 years after enrollment
myocardial infarction, ischemic and hemorrhagic stroke
All-cause mortality
Time Frame: up to 5 years after enrollment
Death by any cause, cardiovascular, infection, cancer, other
Hospitalizations
Time Frame: up to 5 years after enrollment
Any cause hospitalization
Secondary Outcomes
- New diagnosis of diabetes mellitus(up to 1 year after enrollment)
- New diagnosis of Arterial hypertension(up to 1 year after enrollment)
- New diagnosis of carotid atherosclerosis(up to 1 year after enrollment)
- New diagnosis of peripheral artery disease(up to 1 year after enrollment)
- New diagnosis of dyslipidemia(up to 1 year after enrollment)
Investigators
Liontos Angelos
MD, MSc, PhD
University Hospital, Ioannina