Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Mansoura University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Arterial Blood Gases changes
Study Overview
Brief Summary
Evaluate safety and efficacy of application ( high flow nasal canula) in cases with mild hypercapnia, included 30 patients who were hospitalized in Mansoura University chest department with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disease categories (Chronic obstructive pulmonary disease acute exacerbation, pneumonia, Interstitial lung diseases, etc).
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients with mild Hypercapnia
Exclusion Criteria
- •Excluded cases had age less than 18 years or pediatric group .
- •patients with their mental state altered, confused, comatose, severe agitation or non cooperative
- •Cases with moderate or severe Hypercapnia
- •cases in need for immediate invasive mechanical ventilation
- •cases with respiratory rate more than 35 breath per minute.
- •cases with Respiratory exhaustion , fatigue , excess use of respiratory accessory muscles
- •Shock , hemodynamic instability, post arrest cases,
- •cases with facial trauma or severe nasal deformity,
- •Patients with sleep breathing disorders or upper airway obstruction
- •patients with history of home ventilation prior admission
Arms & Interventions
with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30)
with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disorders
Intervention: high flow nasal canula (Device)
Outcomes
Primary Outcomes
Arterial Blood Gases changes
Time Frame: 48 hours
The primary outcome was concerned about changes in Arterial Blood Gases in first 24 h after admission and the same changes 48 h after admission.
Secondary Outcomes
- Number of participants in need for ventilation(7 days)