Cerebral venous drainage in multiple sclerosis
- Conditions
- Nervous System DiseasesMultiple sclerosis
- Registration Number
- ISRCTN75786983
- Lead Sponsor
- Imperial College London
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
1. 18 years of age or greater
2. Informed consent
3. Cases: multiple sclerosis by McDonald criteria with estimated disease severity score < 6, any disease pattern
4. Controls: no other relevant health condition
5. Ability to perform Valsalva manoeuvre
6. Stable disease for one month pre-recruitment
1. Concurrent enrolment in multiple sclerosis drug trial
2. Concurrent masking neurological disease
3. Pregnancy
4. Inability to lie supine
5. Intercurrent infection
6. Superior vena cava obstruction
7. Tricuspid regurgitation
8. Right heart failure
9. Vasculitis
10. Treatment with venodilators (e.g. nitrates)
11. Head and neck surgery or radiotherapy
12. Previous central venous catheterisation
13. Previous central venous thrombosis
14. Thrombophilia
15. Arrhythmia on baseline electrocardiogram (ECG)
16. Postural systolic drop of >30mmHg on standing
17. Steroid treatment within one month
18. Pulmonary hypertension
19. Malignancy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Reflux (>0.88s) in the internal jugular (IJV) and vertebral veins (VVs) using triplex mode<br>2. High resolution B-mode evidence of IJV stenosis in transverse orientation (>50% cross-sectional area diameter reduction) with and without Valsalva<br>3. Undetectable Doppler flow in the IJVs and VVs using colour and Spectral Doppler<br>4. Cross-sectional area change of the IJV from the supine to sitting position
- Secondary Outcome Measures
Name Time Method Inter and intra sonographer reproducibility