Role of ‘Darvyadi Kwath’ and‘Triphla Kwath’ in Ekakushtha(Plaque psoriasis)

Phase 4

Not yet recruiting

• Conditions: Psoriasis vulgaris. Ayurveda Condition: EKAKUSHTHAH,

• Registration Number: CTRI/2022/05/042491
• Lead Sponsor: Ch Brahm Prakash Ayurved Charak Sansthan

Brief Summary

Ekakushtha is one of 18 types of kushtha described  in Samhitas. Although Ekakushtha is said to be Vata- Kaphaja, there is involvement of all the three doshas in all types of kushtha.The clinical features of Ekakushtha as described in Ayurveda literature are Aswedanamm(~anhidrosis),Mahavastu(~extensively spreading dermoses) and Matsya-Shaklopam (~desquamation), Krushna – Aruna Varna (~erythmatous).

Psoriasis is a chronic, disfiguring, inflammatory and proliferative condition of skin. It has several subtypes but plaque psoriasis is its most common variant. The most characteristic lesion consists of red, scaly, sharply demarcated, indurated papules and/or plaques, often present over the scalp and extensor surfaces of skin but can be seen anywhere on the body.

This study is to compare the effectiveness of *Darvyadi Kwath and Triphala Kwath* in management of *Ekakushta* (Plaque Psoriasis).Total number of the patient is 56. 28 in each group.In group A Darvyathi kwath is given in dose of 40ml twice a day empty stomach.In group B Triphala Kwath  is given in dose of 40ml twice a day empty stomach.

Study design is single centered, open label, randomised , interventional type ,comparative study.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-17
• Last Update Posted: 2022-10-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• Age: 20 year to 60years.
• Sex: both sex(male and females).
• Patient having the clinical feature of Ekakushtha(Plaque Psoriasis).
• Patient having chronicity of psoriasis less than 5 year and more than 6 month.
• e.Patient willing to give consent for trial with firm residential address and contact.

Exclusion Criteria

less than 20 year and more than 60 years. b. Patient suffering from Diabetes Mellitus, Cancer, Cardiac Problems, Uncontrolled Hypertension, Acquired Immunodeficiency Syndrome (AIDS), Tuberculosis (TB), Renal c. Disorder. d. Other co-skin disease. e. Pregnant women and lactating mother. f. Drug or Alcohol Abuse: A Known or suspected history of chronic alcohol or drug abuse. g. Hypersensitivity to any of the drugs to be used in study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Improvement in Psoriasis Area And Severity Index(PASI) Score	DAY 1 | DAY 15 | DAY 30 | DAY 45

Secondary Outcome Measures

Name	Time	Method
Improvement in symptom severity of Ekkushtha(Plaque Psoriasis).
Improvement in inflammatory markers (ESR, CRP).	DAY 1

Trial Locations

Locations (1)

Ch Brahm Prakash Ayurved Charak Sansthan; 🇮🇳 West, DELHI, India

Ch Brahm Prakash Ayurved Charak Sansthan

🇮🇳West, DELHI, India

Dr Yogesh Kumar Pandey

Principal investigator

9013858523

dryogeshpandey@gmail.com