Losartan Effects on the Extinction of Conditioned Fear in Humans
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 70
- Locations
- 1
- Primary Endpoint
- Losartan effects on neural activity during fear extinction
Study Overview
Brief Summary
The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
Detailed Description
In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy subjects without past or current psychiatric or neurological disorders
Exclusion Criteria
- •history of head injury
- •medical or psychiatric illness
- •hypertension
Arms & Interventions
Losartan group
Intervention: Losartan (Drug)
Placebo group
Intervention: Placebo Oral Tablet (Drug)
Outcomes
Primary Outcomes
Losartan effects on neural activity during fear extinction
Time Frame: 1 hour
Neural activity will be measured by functional magnetic resonance imaging (fMRI). Effects of treatment will be evaluated by comparing extinction-related neural activity in the core extinction network (prefrontal cortex, limbic regions) between the active treatment and the placebo group.
Secondary Outcomes
- Losartan effects on skin conductance responses during fear extinction(1 hour)
Investigators
Benjamin Becker
Professor
University of Electronic Science and Technology of China