Losartan Effects on the Extinction of Conditioned Fear in Humans
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Losartan effects on neural activity during fear extinction
研究概览
简要总结
The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
详细描述
In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without past or current psychiatric or neurological disorders
排除标准
- •history of head injury
- •medical or psychiatric illness
- •hypertension
研究组 & 干预措施
Losartan group
干预措施: Losartan (Drug)
Placebo group
干预措施: Placebo Oral Tablet (Drug)
结局指标
主要结局
Losartan effects on neural activity during fear extinction
时间窗: 1 hour
Neural activity will be measured by functional magnetic resonance imaging (fMRI). Effects of treatment will be evaluated by comparing extinction-related neural activity in the core extinction network (prefrontal cortex, limbic regions) between the active treatment and the placebo group.
次要结局
- Losartan effects on skin conductance responses during fear extinction(1 hour)
研究者
Benjamin Becker
Professor
University of Electronic Science and Technology of China