Losartan and Emotion Processing

Not Applicable

• Conditions: Healthy
• Interventions: Drug: Placebo Oral Tablet; Drug: Losartan

• Registration Number: NCT03396523
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear

Detailed Description

In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.

Study Timeline

• Study Start: 2018-01-04
• Study First Submitted: 2018-01-04
• Study First Submitted QC: 2018-01-04
• Study First Posted: 2018-01-11
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-04
• Last Update Posted: 2018-06-06
• Primary Completion: 2018-10-31
• Study Completion: 2018-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 70

Inclusion Criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

• history of head injury
• medical or psychiatric illness
• hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo group	Placebo Oral Tablet	-
Losartan group	Losartan	-

Primary Outcome Measures

Name	Time	Method
Losartan effects on neural activity during fear extinction	1 hour	Neural activity will be measured by functional magnetic resonance imaging (fMRI). Effects of treatment will be evaluated by comparing extinction-related neural activity in the core extinction network (prefrontal cortex, limbic regions) between the active treatment and the placebo group.

Secondary Outcome Measures

Name	Time	Method
Losartan effects on skin conductance responses during fear extinction	1 hour	Effects of treatment will be evaluated by comparing extinction-related skin conductance responses between the active treatment and the placebo group.

Trial Locations

Locations (1)

University of Electronic Science and Technology of China; 🇨🇳 Chengdu, Sichuan, China