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Clinical Trials/NCT03396523
NCT03396523UnknownNot Applicable

Losartan Effects on the Extinction of Conditioned Fear in Humans

University of Electronic Science and Technology of China1 site in 1 country70 target enrollmentStarted: January 4, 2018Last updated:
Conditions
Interventions
Drugs

Trial Snapshot

Phase
Not Applicable
Sponsor
Enrollment
70
Locations
1
Primary Endpoint
Losartan effects on neural activity during fear extinction

Study Overview

Brief Summary

The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear

Detailed Description

In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Basic Science
Masking
Double (Participant, Investigator)

Eligibility Criteria

Ages
18 Years to 30 Years (Adult)
Sex
Male
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

  • history of head injury
  • medical or psychiatric illness
  • hypertension

Arms & Interventions

Losartan group

Experimental

Intervention: Losartan (Drug)

Placebo group

Placebo Comparator

Intervention: Placebo Oral Tablet (Drug)

Outcomes

Primary Outcomes

Losartan effects on neural activity during fear extinction

Time Frame: 1 hour

Neural activity will be measured by functional magnetic resonance imaging (fMRI). Effects of treatment will be evaluated by comparing extinction-related neural activity in the core extinction network (prefrontal cortex, limbic regions) between the active treatment and the placebo group.

Secondary Outcomes

  • Losartan effects on skin conductance responses during fear extinction(1 hour)

Investigators

Sponsor
University of Electronic Science and Technology of China
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Benjamin Becker

Professor

University of Electronic Science and Technology of China

Study Sites (1)

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