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临床试验/NCT03396523
NCT03396523Unknown不适用

Losartan Effects on the Extinction of Conditioned Fear in Humans

University of Electronic Science and Technology of China1 个研究点 分布在 1 个国家目标入组 70 人开始时间: 2018年1月4日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
发起方
入组人数
70
试验地点
1
主要终点
Losartan effects on neural activity during fear extinction

研究概览

简要总结

The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear

详细描述

In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • Healthy subjects without past or current psychiatric or neurological disorders

排除标准

  • history of head injury
  • medical or psychiatric illness
  • hypertension

研究组 & 干预措施

Losartan group

Experimental

干预措施: Losartan (Drug)

Placebo group

Placebo Comparator

干预措施: Placebo Oral Tablet (Drug)

结局指标

主要结局

Losartan effects on neural activity during fear extinction

时间窗: 1 hour

Neural activity will be measured by functional magnetic resonance imaging (fMRI). Effects of treatment will be evaluated by comparing extinction-related neural activity in the core extinction network (prefrontal cortex, limbic regions) between the active treatment and the placebo group.

次要结局

  • Losartan effects on skin conductance responses during fear extinction(1 hour)

研究者

发起方
University of Electronic Science and Technology of China
申办方类型
Other
责任方
Principal Investigator
主要研究者

Benjamin Becker

Professor

University of Electronic Science and Technology of China

研究点 (1)

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