Challenge study: The efficacy of fish oil supplementation on cognitive performance in MCI patients and the influence of the APOE-epsilon4 allele.
- Conditions
- 10012272cognitive decline
- Registration Number
- NL-OMON32051
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
- Men and women
- Diagnosed as having amnestic MCI: based on specific memory disturbances (cut-off of 1 sd, single or multiple domain amnestic MCI)
- Informed consent signed
Exclusion Criteria
- Current or recent (<4 weeks) use of fish oil supplements
- Consumption of fish more than 2 times/week
- Current use of dementia (Alzheimer) medication
- Current use of Acenocoumarol or other anti-thrombotic drugs
- Use of more than 4 glasses of alcohol per day
- Unable to participate as judged by the responsible medical physician
- Allergy to fish(oil)
- Swallowing problems
- Participation in another clinical trial less than 2 months before the start of the trial or at the same time
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Cognitive performance as assessed by sensitive cognitive tests measuring<br /><br>reaction time, visual memory and attention. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Cerebral blood flow will be measured by Trans-cranial Doppler.</p><br>