Pericapsular Nerve Group Block Mitigates Surgical Stress and Enhances Analgesia in Total Hip Arthroplasty: A Randomized Controlled Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Neutrophil-to-lymphocyte ratio
研究概览
简要总结
Effect of PENG block on NLR and PLR following hip arthroplasty
详细描述
The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state by several hours and may alert clinicians to the ongoing pathological process early. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine, enabling a better understanding of the biology of inflammation, the linkage and antagonism between innate and adaptive immunity, and their clinical consequences for health and disease.
NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with ASA classification I-III
- •Aged 60-100 years
- •Who will be scheduled for hip arthroplasty under spinal anesthesia
排除标准
- •Patients who have a history of bleeding diathesis
- •Take anticoagulant therapy
- •History of chronic pain before surgery
- •Multiple trauma
- •patients unable to assess their pain (dementia)
- •patients operated under general anesthesia
- •patients having an infection in the region of the procedure
- •the patient who does not accept the procedure
研究组 & 干预措施
Sham blocks
PENG block with 20ml of 0.9% sodium chloride
干预措施: 0.9% Sodium Chloride Injection (Drug)
PENG block
PENG block with 20ml 0f 0.2% ropivacaine
干预措施: Ropivacaine 0.2% Injectable Solution (Drug)
结局指标
主要结局
Neutrophil-to-lymphocyte ratio
时间窗: 12 hours after surgery
Neutrophil to lymphocyte ratio (NLR) is used as a marker of subclinical inflammation. It is calculated by dividing the number of neutrophils by number of lymphocytes, usually from peripheral blood sample, but sometimes also from cells that infiltrate tissue, such as tumor.
次要结局
- PLR(48 hours after surgery)
- NLR(48 hours after surgery)
- first need of opiate(48 hours after procedure)
- Opioid Consumption(48 hours after surgery)
- Pain score(24 hours after surgery)