The Relationship Between CD138 Count of Endometrium and Reproductive Outcome

Not Applicable

Completed

• Conditions: Infertility

• Registration Number: NCT03689101
• Lead Sponsor: Reproductive & Genetic Hospital of CITIC-Xiangya

Brief Summary

It's well known, endometritis affects reproductive outcomes. Though CD138 counting as one new diagnosis measure for endometritis, diagnostic criterion of this measure isn't consistent. And if the CD138 counting is correlation to the outcome of reproductive is not clear.

Firstly, This study aims to explore the relationship between endometrial CD138 count and pregnancy outcome following frozen embryo transfer in natural cycles. Secondly , the investigators want to find a cut-off value which is related to reproduction outcome.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03-21
• Study First Submitted: 2018-09-21
• Study First Submitted QC: 2018-09-24
• Study First Posted: 2018-09-28
• Primary Completion: 2018-11-01
• Study Completion: 2019-02-02
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-09
• Last Update Posted: 2022-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 148

Inclusion Criteria

• age between20 and 38 years;
• regular menstrual cycles;
• body mass index (BMI) ranged from 18 to 25

Exclusion Criteria

• uterine abnormalities;
• intrauterine adhesions（moderate - severe）, advanced endometriosis, adenomyosis, untreated hydrosalpinx, uterine fibroids (submucosal fibroids, nonmucosal fibroids >4.0 cm and/or endometrial pressure)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
CD138 counting	7 days after LH surge (LH+7)
clinical pregnancy rate	about 28 days after embryo transfer

Trial Locations

Locations (1)

Reproductive & Genetic Hospital of CITIC-XIANGYA; 🇨🇳 Changsha, Hunan, China