Reduced Nicotine Cigarette Purchasing Decisions
Trial Snapshot
- Phase
- Early Phase 1
- Status
- Completed
- Sponsor
- Johns Hopkins University
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- Demand Intensity
Study Overview
Brief Summary
The goal of this project is to experimentally evaluate how expectations about reduced-nicotine cigarettes as well as actual nicotine content interact to determine behavioral and subjective response for these novel products.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 21 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Full Nicotine Expectancy, Reduced Nicotine Dose
Receive reduced nicotine cigarette expecting full
Intervention: Reduced Nicotine Cigarettes (Drug)
Full Nicotine Expectancy, Reduced Nicotine Dose
Receive reduced nicotine cigarette expecting full
Intervention: Average Nicotine Expectancy (Behavioral)
Full Nicotine Expectancy, Full Nicotine Dose
Receive full nicotine cigarette expecting full
Intervention: Full Nicotine Cigarettes (Drug)
Full Nicotine Expectancy, Full Nicotine Dose
Receive full nicotine cigarette expecting full
Intervention: Average Nicotine Expectancy (Behavioral)
Reduced Nicotine Expectancy, Full Nicotine Dose
Receive full nicotine cigarette expecting reduced
Intervention: Full Nicotine Cigarettes (Drug)
Reduced Nicotine Expectancy, Full Nicotine Dose
Receive full nicotine cigarette expecting reduced
Intervention: Very Low Nicotine Expectancy (Behavioral)
Reduced Nicotine Expectancy, Reduced Nicotine Dose
Receive reduced nicotine cigarette expecting reduced
Intervention: Reduced Nicotine Cigarettes (Drug)
Reduced Nicotine Expectancy, Reduced Nicotine Dose
Receive reduced nicotine cigarette expecting reduced
Intervention: Very Low Nicotine Expectancy (Behavioral)
Outcomes
Primary Outcomes
Demand Intensity
Time Frame: Four times over approximately two weeks
Consumption of cigarettes at unconstrained price as measured by an incentivized demand task. Minimum value is 0, maximum value is not constrained. Higher scores indicate more cigarette consumption at unconstrained price (a worse outcome).
Demand Elasticity
Time Frame: Four times over approximately two weeks
Changes in cigarette consumption with changes in price as measured by an incentivized demand task. There is no minimum or maximum value. Higher scores indicate greater cigarette price sensitivity (a better outcome). Values are log-transformed. Data are presented for all subjects with non-zero data (zero data cannot be analyzed with a demand function so elasticity cannot be generated)
Secondary Outcomes
- Minnesota Nicotine Withdrawal Scale(Post-cigarette administration four times over approximately two weeks)