Nicotine
- Generic Name
- Nicotine
- Brand Names
- Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
- Drug Type
- Small Molecule
- Chemical Formula
- C10H14N2
- CAS Number
- 54-11-5
- Unique Ingredient Identifier
- 6M3C89ZY6R
- Background
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
- Indication
For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
- Associated Conditions
- Withdrawal Nicotine
- Associated Therapies
- Smoking cessation therapy
Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation
Not Applicable
Recruiting
- Conditions
- Smoking
- Interventions
- Other: AcupunctureOther: Sham acupressureBehavioral: Smoking cessation counselingOther: Auricular acupressureOther: Sham acupuncture
- First Posted Date
- 2025-04-16
- Last Posted Date
- 2025-05-11
- Lead Sponsor
- The University of Hong Kong
- Target Recruit Count
- 270
- Registration Number
- NCT06931054
- Locations
- 🇭🇰
School of Nursing, The University of Hong Kong, Hong Kong, Hong Kong
iCanQuit Smoking Cessation Among Hispanic Adults
Phase 3
Not yet recruiting
- Conditions
- Cigarette Smoking-Related Carcinoma
- Interventions
- Device: iCanQuit Smartphone App Smoking Cessation ProgramOther: Survey AdministrationOther: Interview
- First Posted Date
- 2025-02-06
- Last Posted Date
- 2025-02-19
- Lead Sponsor
- Fred Hutchinson Cancer Center
- Target Recruit Count
- 854
- Registration Number
- NCT06811038
- Locations
- 🇺🇸
Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia
Not Applicable
Not yet recruiting
- Conditions
- Cigarette Smoking-Related Carcinoma
- Interventions
- Procedure: Carbon Monoxide MeasurementOther: Internet-Based InterventionOther: Survey Administration
- First Posted Date
- 2025-01-08
- Last Posted Date
- 2025-04-08
- Target Recruit Count
- 1000
- Registration Number
- NCT06763536
- Locations
- 🇺🇸
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers
Not Applicable
Completed
- Conditions
- Cigarette Smoking-Related Carcinoma
- Interventions
- Procedure: Biospecimen CollectionProcedure: Cognitive AssessmentOther: InterviewBehavioral: Smoking Cessation InterventionOther: Survey AdministrationOther: Tobacco Cessation Counseling
- First Posted Date
- 2024-12-20
- Last Posted Date
- 2024-12-20
- Target Recruit Count
- 27
- Registration Number
- NCT06745154
- Locations
- 🇺🇸
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids
Not Applicable
Completed
- Conditions
- HealthyNicotine AddictionElectronic Cigarette Use
- Interventions
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2024-09-27
- Lead Sponsor
- Rochester Institute of Technology
- Target Recruit Count
- 72
- Registration Number
- NCT06602492
- Locations
- 🇺🇸
Rochester Institute of Technology, Rochester, New York, United States
The Options 2 Study
Phase 4
Not yet recruiting
- Conditions
- SmokerSmoking Cessation
- Interventions
- Drug: Mini Nicotine lozenges
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2025-04-22
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 300
- Registration Number
- NCT06595459
- Locations
- 🇺🇸
University of Wisconsin, Madison, Wisconsin, United States
Rural Smoking Cessation
Not Applicable
Not yet recruiting
- Conditions
- Smoking Cessation
- Interventions
- Drug: Nicoderm CQ nicotine patch
- First Posted Date
- 2024-09-05
- Last Posted Date
- 2025-01-16
- Lead Sponsor
- Masonic Cancer Center, University of Minnesota
- Target Recruit Count
- 272
- Registration Number
- NCT06584929
Adaptive Use of Nicotine Substitution to Maintain Smoking Reduction/Abstinence in Nicotine Responders
Phase 3
Active, not recruiting
- Conditions
- Harm ReductionSmoking Cessation
- Interventions
- Other: NJOY e-cigaretteOther: on!
- First Posted Date
- 2024-08-15
- Last Posted Date
- 2025-05-21
- Lead Sponsor
- Rose Research Center, LLC
- Target Recruit Count
- 150
- Registration Number
- NCT06554873
- Locations
- 🇺🇸
Rose Research Center, Raleigh, North Carolina, United States
C-Raven, a Virtual Tobacco Cessation Intervention in the Community
Phase 4
Recruiting
- Conditions
- Tobacco Dependence
- Interventions
- Behavioral: C-Raven Virtual Tobacco Cessation CounselingOther: Community Health WorkerOther: Lung Cancer Screening
- First Posted Date
- 2024-08-09
- Last Posted Date
- 2024-11-12
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 30
- Registration Number
- NCT06545669
- Locations
- 🇺🇸
Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial
Phase 4
Not yet recruiting
- Conditions
- Tobacco Use DisorderPsychiatric DisorderNicotine Dependence
- Interventions
- Device: Brainsway H4 deep Repetitive Transcranial Magnetic Stimulation (rTMS) coil
- First Posted Date
- 2024-08-02
- Last Posted Date
- 2024-08-02
- Lead Sponsor
- Centre for Addiction and Mental Health
- Target Recruit Count
- 40
- Registration Number
- NCT06534047
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