Nicotine

Generic Name: Nicotine

Brand Names: Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₄N_₂

CAS Number: 54-11-5

Unique Ingredient Identifier: 6M3C89ZY6R

Background: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication: For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions: Withdrawal Nicotine

Associated Therapies: Smoking cessation therapy

Clinical Trials

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Phase 1

Recruiting

Conditions: Nicotine Vaping
Nicotine Dependence

Interventions: Drug: (S)-Nicotine
Drug: (R)- nicotine
Drug: Racemic nicotine

First Posted Date: 2023-07-27

Last Posted Date: 2025-04-03

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 18

Registration Number: NCT05962229

Locations: 🇺🇸
Zuckerberg San Francisco General Hospital (ZSFG), San Francisco, California, United States

Online Tai Chi Intervention to Promote Smoking Cessation Among Cancer Survivors

Not Applicable

Recruiting

Conditions: Cancer

Interventions: Other: Best Practice
Procedure: Carbon Monoxide Measurement
Other: Internet-Based Intervention
Drug: Nicotine Replacement
Other: Survey Administration
Other: Tai Chi

First Posted Date: 2023-07-12

Last Posted Date: 2025-03-27

Lead Sponsor: Ohio State University Comprehensive Cancer Center

Target Recruit Count: 200

Registration Number: NCT05941858

Locations: 🇺🇸
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Smoking Cessation in a Cohort HIV+ Rio de Janeiro, Brazil.

Completed

Conditions: Smoking Cessation
Nicotine Replacement Therapy
Brachial Flow Mediated Dilatation

Interventions: Drug: Nicotine replacement

First Posted Date: 2023-05-24

Last Posted Date: 2023-05-24

Lead Sponsor: Instituto Fernandes Figueira

Target Recruit Count: 115

Registration Number: NCT05873738

Locations: 🇧🇷
Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil

Effectiveness of Different THR Products in Adult Population

Phase 3

Not yet recruiting

Conditions: Smoking Cessation

Interventions: Device: E-Cigarette
Drug: Nicotine patch

First Posted Date: 2023-04-24

Last Posted Date: 2023-11-21

Lead Sponsor: Foundation for a Smoke Free World INC

Target Recruit Count: 258

Registration Number: NCT05825924

Locations: 🇵🇰
South East Hospital and Research Centre, Islamabad, Federal, Pakistan

Assessing the Use of Nicotine Gum to Decrease Betel Nut Chewing in Saipan

Early Phase 1

Withdrawn

Conditions: Betel Nut Cessation

Interventions: Other: Non-medicated gum
Drug: NICOTINE 2MG GUM
Drug: NICOTINE 4MG GUM

First Posted Date: 2023-03-07

Last Posted Date: 2023-09-07

Lead Sponsor: University of Texas Southwestern Medical Center

Registration Number: NCT05758298

Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension

Phase 2

Recruiting

Conditions: Depressive Disorder

Interventions: Drug: Transdermal Nicotine patch

First Posted Date: 2023-02-27

Last Posted Date: 2024-08-26

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 60

Registration Number: NCT05746546

Locations: 🇺🇸
Vanderbilt Psychiatric Hospital, Nashville, Tennessee, United States

Ending Tobacco Use Through Interactive Tailored Messaging for Cambodian People Living With HIV/AIDS

Not Applicable

Recruiting

Conditions: Smoking Cessation
HIV

Interventions: Behavioral: Smartphone-delivered Automated Messaging
Drug: Nicotine patch
Behavioral: Brief Advice to Quit and Smoking Cessation Self Help Materials
Behavioral: Diet Assessment

First Posted Date: 2023-02-27

Last Posted Date: 2025-03-17

Lead Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Target Recruit Count: 800

Registration Number: NCT05746442

Locations: 🇰🇭
National AIDS Authority, Phnom Penh, Cambodia
🇰🇭
National Institute of Public Health, Phnom Penh, Cambodia
🇰🇭
National Center for HIV/AIDS, Dermatology and STD, Phnom Penh, Cambodia

Depressed Mood Improvement Through Nicotine Dosing 3

Phase 2

Recruiting

Conditions: Depressive Disorder

Interventions: Drug: Transdermal Placebo Patch
Drug: Transdermal Nicotine Patch

First Posted Date: 2023-02-27

Last Posted Date: 2024-08-26

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 60

Registration Number: NCT05746273

Locations: 🇺🇸
Vanderbilt Psychiatric Hosptial, Nashville, Tennessee, United States

Financial Incentives for Smoking Cessation Among Mothers

Not Applicable

Completed

Conditions: Cigarette Smoking

Interventions: Behavioral: Best Practices
Behavioral: Financial Incentives
Drug: Nicotine Replacement Therapy

First Posted Date: 2023-02-22

Last Posted Date: 2023-07-28

Lead Sponsor: University of Vermont

Target Recruit Count: 198

Registration Number: NCT05740098

Locations: 🇺🇸
University of Vermont Medical Center, Burlington, Vermont, United States

Examining the Impact of Nicotine Pouches in Rural Ohio and Ohio Appalachia

Early Phase 1

Active, not recruiting

Conditions: Tobacco-Related Carcinoma

Interventions: Procedure: Biospecimen Collection
Drug: Nicotine Oral Pouch
Other: Questionnaire Administration
Drug: Smokeless Tobacco

First Posted Date: 2023-02-15

Last Posted Date: 2024-11-01

Lead Sponsor: Ohio State University Comprehensive Cancer Center

Target Recruit Count: 71

Registration Number: NCT05730439

Locations: 🇺🇸
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

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