Nicotine

Generic Name: Nicotine

Brand Names: Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₄N_₂

CAS Number: 54-11-5

Unique Ingredient Identifier: 6M3C89ZY6R

Background: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication: For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions: Withdrawal Nicotine

Associated Therapies: Smoking cessation therapy

Clinical Trials

Mobile Contingency Management for Marijuana and Tobacco Cessation

Not Applicable

Completed

Conditions: Cigarette Smoking
Marijuana Abuse

Interventions: Drug: bupropion
Drug: transdermal nicotine patch
Drug: Nicotine polacrilex
Drug: nicotine lozenge
Behavioral: counseling for marijuana and smoking cessation
Behavioral: mobile contingency management

First Posted Date: 2016-08-17

Last Posted Date: 2020-02-07

Lead Sponsor: Duke University

Target Recruit Count: 7

Registration Number: NCT02869451

Locations: 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States

Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study)

Phase 4

Completed

Conditions: Major Depressive Disorder

Interventions: Drug: Nicotine

First Posted Date: 2016-06-28

Last Posted Date: 2018-09-27

Lead Sponsor: Vanderbilt University Medical Center

Target Recruit Count: 15

Registration Number: NCT02816138

Locations: 🇺🇸
Vanderbilt Psychiatric Hospital, Nashville, Tennessee, United States

RCT of an Internet Cessation Program Plus Online Social Network for HIV+ Smokers

Not Applicable

Completed

Conditions: Tobacco Use Disorder
HIV

Interventions: Behavioral: AHA
Behavioral: PSFW+
Drug: Nicotine polacrilex

First Posted Date: 2016-05-24

Last Posted Date: 2023-08-04

Lead Sponsor: Montefiore Medical Center

Target Recruit Count: 512

Registration Number: NCT02781090

Locations: 🇺🇸
Johns Hopkins, Baltimore, Maryland, United States
🇺🇸
Montefiore Medical Center, Bronx, New York, United States

Control Systems Approach to Predicting Individualized Dynamics of Nicotine Cravings

Not Applicable

Conditions: Cigarette Smoking
Nicotine Addiction

Interventions: Drug: Nicotine
Device: MR Compatible Nicotine Delivery Device

First Posted Date: 2015-12-31

Last Posted Date: 2017-07-02

Lead Sponsor: Stony Brook University

Target Recruit Count: 23

Registration Number: NCT02643914

Locations: 🇺🇸
Bioengineering Building , Stony Brook University, Stony Brook, New York, United States

Babies Living Safe and Smokefree

Not Applicable

Completed

Conditions: Second Hand Tobacco Smoke
Nicotine Dependence

Interventions: Behavioral: Ask, Advise, Refer
Behavioral: Telebased nutrition counseling
Behavioral: Telebased tobacco counseling
Device: Mobile phone nutrition application
Device: Mobile phone smoking cessation application
Drug: Nicotine polacrilex

First Posted Date: 2015-11-11

Last Posted Date: 2022-03-15

Lead Sponsor: Temple University

Target Recruit Count: 396

Registration Number: NCT02602288

Locations: 🇺🇸
Temple University, Philadelphia, Pennsylvania, United States
🇺🇸
N.O.R.T.H., Inc., Philadelphia, Pennsylvania, United States

The Use of Nicotine Patches Together With E-cigarettes (With and Without Nicotine) for Smoking Cessation

Phase 3

Completed

Conditions: Smoking Cessation

Interventions: Drug: Nicotine patch
Device: e-cigarette
Behavioral: Behavioural support
Drug: Nicotine

First Posted Date: 2015-08-13

Last Posted Date: 2021-08-19

Lead Sponsor: University of Auckland, New Zealand

Target Recruit Count: 1124

Registration Number: NCT02521662

Locations: 🇳🇿
National Institute for Health Innovation, University of Auckland, Auckland, North Island, New Zealand

Pharmacokinetics and Acute Effects of Multiple Dose of Nicotine: Electronic Cigarette and Cigarette

Phase 1

Completed

Conditions: Nicotine Use Disorder

Interventions: Drug: Nicotine

First Posted Date: 2015-07-30

Last Posted Date: 2015-07-30

Lead Sponsor: Parc de Salut Mar

Target Recruit Count: 12

Registration Number: NCT02511704

Locations: 🇪🇸
Institut Hospital del Mar d'Investigacions Mèdiques-IMIM. Parc de Salut Mar., Barcelona, Spain

Effect of Nicotine on Brain Reward Pathways

Phase 1

Completed

Conditions: Depressive Disorder

Interventions: Drug: Nicotine polacrilex

First Posted Date: 2015-01-27

Last Posted Date: 2018-03-22

Lead Sponsor: Mclean Hospital

Target Recruit Count: 46

Registration Number: NCT02346539

Locations: 🇺🇸
McLean Hospital, Belmont, Massachusetts, United States

Effect of Smoking Reduction on Endothelial Glucocalyx and Vascular Function

Phase 4

Conditions: Smoking Cessation

Interventions: Drug: Varenicline
Drug: nicotine

First Posted Date: 2014-12-03

Last Posted Date: 2020-04-03

Lead Sponsor: University of Athens

Target Recruit Count: 600

Registration Number: NCT02307045

Locations: 🇬🇷
''Attikon'' University General Hospital, Athens, Attiki, Greece

Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study

Phase 1

Completed

Conditions: Sarcoidosis

Interventions: Drug: Placebo to Habitrol
Drug: Habitrol

First Posted Date: 2014-10-16

Last Posted Date: 2023-05-12

Lead Sponsor: Ohio State University

Target Recruit Count: 57

Registration Number: NCT02265874

Locations: 🇺🇸
Martha Morehouse Medical Pavilion 2050 Kenny Rd; Ste 2600, Columbus, Ohio, United States

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