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Nicotine

Generic Name
Nicotine
Brand Names
Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
Drug Type
Small Molecule
Chemical Formula
C10H14N2
CAS Number
54-11-5
Unique Ingredient Identifier
6M3C89ZY6R
Background

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions
Withdrawal Nicotine
Associated Therapies
Smoking cessation therapy
Clinical Trials
Related News

Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Students

Not Applicable
Recruiting
Conditions
Smoking Cessation
Interventions
Other: Music Intervention
First Posted Date
2022-10-21
Last Posted Date
2025-02-25
Lead Sponsor
Poitiers University Hospital
Target Recruit Count
120
Registration Number
NCT05589220
Locations
🇫🇷

CHU Poitiers, Poitiers, France

Beta-Adrenergic Modulation of Drug Cue Reactivity

Phase 4
Recruiting
Conditions
Tobacco Use Disorder
Nicotine Dependence
Cigarette Smoking
Interventions
Drug: Placebo Propranolol
Drug: Placebo Patch
First Posted Date
2022-10-20
Last Posted Date
2025-02-20
Lead Sponsor
University of Oklahoma
Target Recruit Count
80
Registration Number
NCT05587361
Locations
🇺🇸

Hardesty Center for Clinical Research and Neuroscience, Tulsa, Oklahoma, United States

Defining Neurobiological Links Between Substance Use and Mental Illness

Not Applicable
Recruiting
Conditions
Substance Use Disorder
Major Depressive Disorder
Normal Physiology
Interventions
Other: Placebo Nicotine Patch
First Posted Date
2022-09-14
Last Posted Date
2025-05-20
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Target Recruit Count
420
Registration Number
NCT05538910
Locations
🇺🇸

National Institute on Drug Abuse, Baltimore, Maryland, United States

Smoking Cessation and Menstrual Cycle Phase

Phase 4
Recruiting
Conditions
Smoking Cessation
Substance Use Disorders
Nicotine Dependence
Nicotine Use Disorder
Tobacco Smoking
Interventions
Other: Timing of nicotine replacement therapy start date
First Posted Date
2022-08-25
Last Posted Date
2023-02-02
Lead Sponsor
Centre for Addiction and Mental Health
Target Recruit Count
1200
Registration Number
NCT05515354
Locations
🇨🇦

Centre for Addiction and Mental Health, Nicotine Dependence Clinic, Toronto, Ontario, Canada

Overcoming Nicotine Dependence to Enable Quitting

Phase 1
Recruiting
Conditions
Tobacco Use
Smoking Cessation
Nicotine Dependence
Smoking Behaviors
Nicotine Withdrawal
Interventions
Behavioral: Practice Quitting (PQ) Counseling
Behavioral: Motivational Interviewing (MI) Counseling
First Posted Date
2022-08-24
Last Posted Date
2024-08-02
Lead Sponsor
Rush University Medical Center
Target Recruit Count
780
Registration Number
NCT05513872
Locations
🇺🇸

Rush University Medical Center, Chicago, Illinois, United States

Adapting and Evaluating a Tobacco Use Cessation Program for People Living With HIV in Uganda and Zambia

Phase 1
Recruiting
Conditions
Tobacco Dependence
Nicotine Dependence
Interventions
Behavioral: text messaging
First Posted Date
2022-08-04
Last Posted Date
2023-11-28
Lead Sponsor
University of Southern California
Target Recruit Count
800
Registration Number
NCT05487807
Locations
🇺🇬

Makerere University, Kampala, Uganda

🇿🇲

University of Zambia, Lusaka, Zambia

Preloaded Combination Nicotine Replacement Therapy on Smoking Cessation of Adult Population in Kazakhstan

Early Phase 1
Not yet recruiting
Conditions
Smoking Behaviors
Smoking Cessation
Smoking, Cigarette
Interventions
Behavioral: Brief Advice (5 A's & 5 R's)
First Posted Date
2022-08-02
Last Posted Date
2023-03-24
Lead Sponsor
Nazarbayev University
Target Recruit Count
200
Registration Number
NCT05484505
Locations
🇰🇿

National Research Cardiac Surgery Center, Astana, Kazakhstan, Astana, Kazakhstan

🇰🇿

Nazarbayev University School of Medicine, Astana, Kazakhstan

Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung

Not Applicable
Withdrawn
Conditions
Lung Non-Small Cell Carcinoma
Stage I Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Stage IA1 Lung Cancer AJCC v8
Head and Neck Squamous Cell Carcinoma
Stage IB Lung Cancer AJCC v8
Stage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Stage IIA Lung Cancer AJCC v8
Stage IIB Lung Cancer AJCC v8
Stage I Lung Cancer AJCC v8
Stage IA2 Lung Cancer AJCC v8
Interventions
Other: Best Practice
Other: Quality-of-Life Assessment
Other: Questionnaire Administration
First Posted Date
2022-06-09
Last Posted Date
2024-04-12
Lead Sponsor
Ohio State University Comprehensive Cancer Center
Registration Number
NCT05412875
Locations
🇺🇸

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Evaluating Smoking Cessation Interventions for PWH in South Africa

Phase 2
Recruiting
Conditions
Smoking Cessation
Comorbidities and Coexisting Conditions
HIV
Interventions
Behavioral: Intensive Behavioral Counselling
Behavioral: Peer Counselling
First Posted Date
2022-06-09
Last Posted Date
2024-08-09
Lead Sponsor
Johns Hopkins University
Target Recruit Count
660
Registration Number
NCT05413122
Locations
🇿🇦

Perinatal HIV Research Unit (PHRU), Soweto, Gauteng, South Africa

Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free

Not Applicable
Completed
Conditions
Tobacco Use
Lung Cancer
Smoking
Interventions
Behavioral: Telephone counseling sessions
Behavioral: Access to a web-based video
Behavioral: Florida Tobacco Quitline
First Posted Date
2022-05-05
Last Posted Date
2025-03-27
Lead Sponsor
H. Lee Moffitt Cancer Center and Research Institute
Target Recruit Count
21
Registration Number
NCT05362318
Locations
🇺🇸

Moffitt Cancer Center, Tampa, Florida, United States

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