Nicotine

Generic Name: Nicotine

Brand Names: Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₁₄N_₂

CAS Number: 54-11-5

Unique Ingredient Identifier: 6M3C89ZY6R

Background: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication: For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions: Withdrawal Nicotine

Associated Therapies: Smoking cessation therapy

Clinical Trials

Effect of the Electronic Cigarette on Withdrawal Symptoms

Not Applicable

Completed

Conditions: Withdrawal State
Mental and Behavioral Disorders

Interventions: Drug: Nicotine

First Posted Date: 2011-10-19

Last Posted Date: 2019-03-27

Lead Sponsor: Queen Mary University of London

Target Recruit Count: 51

Registration Number: NCT01454362

Locations: 🇬🇧
Tobacco Dependence Research Unit, London, United Kingdom

Development of Positive Psychotherapy for Smoking Cessation

Phase 2

Completed

Conditions: Smoking

Interventions: Behavioral: Positive Psychotherapy for smoking cessation
Drug: Nicotine polacrilex
Behavioral: Relaxation training
Behavioral: Behavioral smoking cessation treatment

First Posted Date: 2011-10-14

Last Posted Date: 2015-03-18

Lead Sponsor: Brown University

Target Recruit Count: 66

Registration Number: NCT01451814

Locations: 🇺🇸
Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island, United States

A Study on the Effects of Two Nicotine Replacement Products on Tooth Staining

Not Applicable

Completed

Conditions: Tobacco Dependence

Interventions: Drug: Nicotine

First Posted Date: 2011-09-27

Last Posted Date: 2012-07-10

Lead Sponsor: McNeil AB

Target Recruit Count: 200

Registration Number: NCT01440985

Locations: 🇮🇪
Dental School and Hospital, University College of Cork, Wilton, Cork, Ireland

Nicotine Patch for Marijuana Withdrawal

Phase 4

Completed

Conditions: Marijuana Dependence

Interventions: Drug: Placebo Patch
Drug: Nicotine

First Posted Date: 2011-07-22

Last Posted Date: 2015-04-30

Lead Sponsor: Southern Illinois University Carbondale

Target Recruit Count: 127

Registration Number: NCT01400243

Locations: 🇺🇸
Southern Illinois University, Carbondale, Illinois, United States

Nicotine Pharmacodynamics With a New Oral Nicotine Replacement Therapy and Nicotine Gum

Not Applicable

Completed

Conditions: Tobacco Dependence

Interventions: Drug: Nicotine

First Posted Date: 2011-06-07

Last Posted Date: 2012-07-10

Lead Sponsor: McNeil AB

Target Recruit Count: 346

Registration Number: NCT01368016

Locations: 🇸🇪
Clinical Pharmacology, McNeil AB, Lund, Sweden
🇸🇪
Karolinska Trial Alliance (KTA), University Hospital Huddinge, Stockholm, Sweden

Effects of Contingency Management and Nicotine Replacement Therapy on Youth Smoking

Phase 1

Completed

Conditions: Cigarette Smoking Behavior

Interventions: Drug: Nicotine polacrilex

First Posted Date: 2011-05-25

Last Posted Date: 2016-05-13

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 60

Registration Number: NCT01359709

Locations: 🇺🇸
University California, Los Angeles, Los Angeles, California, United States

Multiple-dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products

Phase 1

Completed

Conditions: Tobacco Dependence

Interventions: Drug: Nicotine

First Posted Date: 2011-03-24

Last Posted Date: 2012-07-10

Lead Sponsor: McNeil AB

Target Recruit Count: 50

Registration Number: NCT01321931

Locations: 🇸🇪
McNeil AB Clinical Pharmacology R&D, Lund, Sweden

Study to Determine if a New Nicotine Replacement Therapy Can Safely Help Smokers to Quit Smoking

Phase 3

Terminated

Conditions: Tobacco Dependence

Interventions: Drug: Placebo
Drug: Nicotine

First Posted Date: 2011-02-15

Last Posted Date: 2012-04-23

Lead Sponsor: McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.

Target Recruit Count: 257

Registration Number: NCT01296698

Locations: 🇺🇸
Stark Pharmacy, Overland Park, Kansas, United States
🇺🇸
T.B. Bond Pharmacy, Hillsboro, Texas, United States
🇺🇸
Medicap Pharmacy, Clarksdale, Mississippi, United States

and more 14 locations

Single-dose Pharmacokinetics of Oral Nicotine Replacement Products

Not Applicable

Completed

Conditions: Tobacco Dependence

Interventions: Drug: Nicotine
Drug: Nicotine Gum

First Posted Date: 2010-10-26

Last Posted Date: 2011-10-06

Lead Sponsor: Johnson & Johnson Consumer and Personal Products Worldwide

Target Recruit Count: 40

Registration Number: NCT01228617

Locations: 🇸🇪
Clinical Trial Unit, Clinical Research and Trial Centre, Lund, Sweden

Nicotinic Modulation of the Default Network

Not Applicable

Completed

Conditions: Magnetic Resonance Imaging
Cognition
Nicotine
Mecamylamine

Interventions: Drug: Placebo
Drug: Nicotine
Drug: Mecamylamine

First Posted Date: 2010-10-19

Last Posted Date: 2019-08-19

Lead Sponsor: University of Maryland, Baltimore

Target Recruit Count: 21

Registration Number: NCT01223404

Locations: 🇺🇸
National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, United States
🇺🇸
Maryland Psychiatric Research Center, Baltimore, Maryland, United States

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