MedPath

Nicotine

Generic Name
Nicotine
Brand Names
Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
Drug Type
Small Molecule
Chemical Formula
C10H14N2
CAS Number
54-11-5
Unique Ingredient Identifier
6M3C89ZY6R
Background

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions
Withdrawal Nicotine
Associated Therapies
Smoking cessation therapy
Clinical Trials
Related News

Integrating Tobacco Use Cessation Into HIV Care and Treatment in Kisumu County, Kenya

Phase 4
Active, not recruiting
Conditions
Tobacco Use
Tobacco Use Cessation
Interventions
Behavioral: Tobacco Use Cessation Counselling Sessions
First Posted Date
2022-04-28
Last Posted Date
2025-05-07
Lead Sponsor
University of California, San Francisco
Target Recruit Count
580
Registration Number
NCT05351606
Locations
🇰🇪

Kenya Medical Research Institute (KEMRI), Kisumu, Kenya

Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation (Cess@Tion)

Phase 3
Completed
Conditions
Smoking Cessation
Interventions
Combination Product: Cytisine plus nicotine delivered via an e-cigarette
First Posted Date
2022-04-05
Last Posted Date
2024-12-19
Lead Sponsor
University of Auckland, New Zealand
Target Recruit Count
807
Registration Number
NCT05311085
Locations
🇳🇿

National Institute for Health Innovation, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

Effect of Nicotine Transdermal Patch on Cognitive Function and Glycolipid Metabolism in Non-smoking Schizophrenia

Early Phase 1
Conditions
Schizophrenia
Interventions
First Posted Date
2022-03-31
Last Posted Date
2022-03-31
Lead Sponsor
Sir Run Run Shaw Hospital
Target Recruit Count
80
Registration Number
NCT05301660

Easy Access to Smoking Cessation for People Receiving Opioid Agonist Therapy Who Are Smoking Tobacco

Not Applicable
Active, not recruiting
Conditions
Smoking Cessation
Substance-Related Disorders
Interventions
Behavioral: Smoking cessation counselling
Other: Screening for use of tobacco products
Other: Screening for interest in smoking cessation
First Posted Date
2022-03-22
Last Posted Date
2024-06-28
Lead Sponsor
Haukeland University Hospital
Target Recruit Count
266
Registration Number
NCT05290025
Locations
🇳🇴

LAR Helse Stavanger HF, Stavanger, Norway

🇳🇴

Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway

Mobile Health Technology for Personalized Tobacco Cessation Support Among Cancer Survivors in Laos

Phase 2
Completed
Conditions
Cigarette Smoking
Interventions
Behavioral: Self-help materials (to support smoking cessation)
Behavioral: Smartphone-based automated treatment for smoking cessation
First Posted Date
2022-02-24
Last Posted Date
2024-08-28
Lead Sponsor
University of Oklahoma
Target Recruit Count
80
Registration Number
NCT05253573
Locations
🇱🇦

Lao National Cancer Center, Vientiane, Lao People's Democratic Republic

🇱🇦

Setthathirath Hospital, Vientiane, Lao People's Democratic Republic

Appeal of Nicotine Pouches Versus Cigarettes in the Ohio Appalachia Population

Early Phase 1
Completed
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Behavioral: Cigarette Smoking
Other: Questionnaire Administration
First Posted Date
2022-02-11
Last Posted Date
2024-05-21
Lead Sponsor
Ohio State University Comprehensive Cancer Center
Target Recruit Count
55
Registration Number
NCT05236894
Locations
🇺🇸

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Mobile Health Technology for Personalized Tobacco Cessation Support in Laos

Phase 2
Recruiting
Conditions
Cigarette Smoking
Interventions
Behavioral: Self-help materials (to support smoking cessation)
Behavioral: Smartphone-based automated treatment for smoking cessation
First Posted Date
2022-02-10
Last Posted Date
2024-07-05
Lead Sponsor
University of Oklahoma
Target Recruit Count
500
Registration Number
NCT05233228
Locations
🇱🇦

Champasak Hospital, Champasak, Lao People's Democratic Republic

🇱🇦

Setthathirath Hospital, Vientiane, Lao People's Democratic Republic

Heart Rate Variability Biofeedback for Smoking Cessation Treatment

Phase 2
Completed
Conditions
Tobacco Smoking
Interventions
Behavioral: Cognitive-Behavioral Smoking Cessation
Biological: Heart Rate Variability Biofeedback
First Posted Date
2022-02-04
Last Posted Date
2024-05-01
Lead Sponsor
Rutgers, The State University of New Jersey
Target Recruit Count
28
Registration Number
NCT05224050
Locations
🇺🇸

Rutgers, School of Arts and Sciences, One Spring Street, New Brunswick, New Jersey, United States

Methadone-Maintained Smokers Switching to E-Cigarettes

Phase 4
Active, not recruiting
Conditions
Nicotine Dependence
Electronic Cigarette Use
Interventions
Drug: Electronic Cigarette
First Posted Date
2022-01-25
Last Posted Date
2024-11-15
Lead Sponsor
Butler Hospital
Target Recruit Count
240
Registration Number
NCT05206435
Locations
🇺🇸

Butler Hospital, Providence, Rhode Island, United States

Evaluating the Pharmacokinetics and Drug Interaction Potential of the Botanical Dietary Supplement Cinnamon

Early Phase 1
Active, not recruiting
Conditions
Interaction Drug Food
Interventions
Dietary Supplement: Cinnamon (2 g)
First Posted Date
2021-12-15
Last Posted Date
2023-12-07
Lead Sponsor
Washington State University
Target Recruit Count
16
Registration Number
NCT05157672
Locations
🇺🇸

Washington State University College of Pharmacy and Pharmaceutical Sciences, Spokane, Washington, United States

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