MedPath

Nicotine

Generic Name
Nicotine
Brand Names
Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
Drug Type
Small Molecule
Chemical Formula
C10H14N2
CAS Number
54-11-5
Unique Ingredient Identifier
6M3C89ZY6R
Background

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions
Withdrawal Nicotine
Associated Therapies
Smoking cessation therapy
Clinical Trials
Related News

Reduced Nicotine Cigarette Purchasing Decisions

Early Phase 1
Completed
Conditions
Tobacco Use Disorder
Interventions
Drug: Full Nicotine Cigarettes
Behavioral: Average Nicotine Expectancy
Behavioral: Very Low Nicotine Expectancy
First Posted Date
2021-08-11
Last Posted Date
2024-02-09
Lead Sponsor
Johns Hopkins University
Target Recruit Count
21
Registration Number
NCT04999644
Locations
🇺🇸

Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States

Research and Innovation to Stop E-cigarette/Vaping in Young Adults

Phase 4
Completed
Conditions
Nicotine Dependence
E-Cig Use
Interventions
Behavioral: Phone Counseling
Behavioral: Digital Coaching
First Posted Date
2021-07-23
Last Posted Date
2024-07-29
Lead Sponsor
Ohio State University
Target Recruit Count
508
Registration Number
NCT04974580
Locations
🇺🇸

The Ohio State University, Columbus, Ohio, United States

Mindfulness-based Smoking Cessation Enhanced With Mobile Technology

Not Applicable
Completed
Conditions
Cigarette Smoking
Interventions
Behavioral: Mindfulness-Based Addiction Treatment
Behavioral: Self-help materials
Behavioral: iQuit Mindfully
First Posted Date
2021-07-16
Last Posted Date
2025-03-12
Lead Sponsor
Georgia State University
Target Recruit Count
502
Registration Number
NCT04965181
Locations
🇺🇸

Georgia State University, Atlanta, Georgia, United States

Quit Smoking Study for People Who Use E-Cigarettes

Phase 2
Completed
Conditions
Quitting Smoking
Nicotine Addiction
E-Cig Use
Interventions
Behavioral: Continue electronic cigarettes
Behavioral: Quit electronic cigarettes
First Posted Date
2021-07-01
Last Posted Date
2025-05-22
Lead Sponsor
University of Vermont
Target Recruit Count
396
Registration Number
NCT04946825
Locations
🇺🇸

University of Vermont, Burlington, Vermont, United States

Acute Effects of Vaping Nicotine on Cognition in Young Adults

Not Applicable
Completed
Conditions
Nicotine Addiction
Vaping
Interventions
Drug: Placebo pod
First Posted Date
2021-05-25
Last Posted Date
2024-03-22
Lead Sponsor
Yale University
Target Recruit Count
8
Registration Number
NCT04901208
Locations
🇺🇸

Yale University, New Haven, Connecticut, United States

Evaluation of Different Smoking Cessation Protocols: Nicotine Replacement, Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT) or Hypnotherapy in Cancer Patients Scheduled for Surgery

Not Applicable
Terminated
Conditions
Digestive Cancer
Melanoma
Breast Cancer
Gynecologic Cancer
Interventions
Behavioral: Motivational Interviewing (MI)
Behavioral: Cognitive Behavioural Therapy (CBT)
Behavioral: Hypnotherapy
First Posted Date
2021-05-24
Last Posted Date
2024-11-07
Lead Sponsor
Institut Cancerologie de l'Ouest
Target Recruit Count
22
Registration Number
NCT04899492
Locations
🇫🇷

Institut de Cancerologie de l'Ouest (ICO), Saint-Herblain, France

Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation

Not Applicable
Completed
Conditions
Smoking Cessation
Interventions
Behavioral: Android Wear smartwatch
Behavioral: Adaptive Treatment
Behavioral: interviewing-based counseling
First Posted Date
2021-04-09
Last Posted Date
2025-03-28
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
60
Registration Number
NCT04839198
Locations
🇺🇸

The University of Texas Health Science Center at Houston, Houston, Texas, United States

E-cigarette Nicotine Study

Phase 2
Completed
Conditions
Nicotine Dependence
Electronic Cigarette Use
Cigarette Smoking
Interventions
Device: Juul e-cigarette
Behavioral: Reduction
First Posted Date
2021-01-14
Last Posted Date
2022-08-26
Lead Sponsor
University of Vermont
Target Recruit Count
77
Registration Number
NCT04709471
Locations
🇺🇸

University of Vermont, Burlington, Vermont, United States

Do Flavors Increase the Addiction Potential of Nicotine?

Phase 2
Completed
Conditions
Nicotine Dependence
Interventions
Device: JUUL e-cigarette
First Posted Date
2021-01-06
Last Posted Date
2022-03-22
Lead Sponsor
University of Vermont
Target Recruit Count
19
Registration Number
NCT04696380
Locations
🇺🇸

University of Vermont, Burlington, Vermont, United States

Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use

Not Applicable
Completed
Conditions
Head and Neck Squamous Cell Carcinoma
Lung Non-Small Cell Carcinoma
Interventions
Other: Quality of Life Assessment
Other: Best Practice
Other: Tobacco Cessation Counseling
Other: Questionnaire Administration
First Posted Date
2021-01-05
Last Posted Date
2025-03-25
Lead Sponsor
Thomas Jefferson University
Target Recruit Count
19
Registration Number
NCT04694846
Locations
🇺🇸

Sidney Kimmel Cancer Center at Thomas Jefferson Univeristy, Philadelphia, Pennsylvania, United States

🇺🇸

Jefferson Health, Methodist Hospital, Philadelphia, Pennsylvania, United States

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