MedPath

Nicotine

Generic Name
Nicotine
Brand Names
Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
Drug Type
Small Molecule
Chemical Formula
C10H14N2
CAS Number
54-11-5
Unique Ingredient Identifier
6M3C89ZY6R
Background

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions
Withdrawal Nicotine
Associated Therapies
Smoking cessation therapy

5HT3 Antagonism and Auditory Gating in Schizophrenia

Not Applicable
Completed
Conditions
Schizophrenia
First Posted Date
2001-07-05
Last Posted Date
2009-01-21
Lead Sponsor
US Department of Veterans Affairs
Registration Number
NCT00018850
Locations
🇺🇸

VAMC, Denver, Colorado, United States

Combinations of Pharmacologic Smoking Cessation Treatments

Phase 1
Completed
Conditions
Smoking
First Posted Date
2001-07-05
Last Posted Date
2009-01-21
Lead Sponsor
US Department of Veterans Affairs
Registration Number
NCT00018187
Locations
🇺🇸

VA Greater Los Angeles Healthcare System, Los Angeles, California, United States

Treatment to Quit Smoking

Phase 2
Completed
Conditions
Smoking
First Posted Date
2001-07-05
Last Posted Date
2009-01-21
Lead Sponsor
US Department of Veterans Affairs
Registration Number
NCT00018161
Locations
🇺🇸

Veterans Affairs Medical Center, Durham, North Carolina, United States

Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation

Phase 2
Completed
Conditions
Smoking
Interventions
First Posted Date
2001-07-05
Last Posted Date
2010-09-15
Lead Sponsor
US Department of Veterans Affairs
Target Recruit Count
158
Registration Number
NCT00018148
Locations
🇺🇸

VA Eastern Colorado Health Care System, Denver, Denver, Colorado, United States

Behavioral Economics of Human Drug Self-Administration

Completed
Conditions
Drug Dependence
First Posted Date
2000-06-02
Last Posted Date
2005-06-24
Lead Sponsor
National Center for Research Resources (NCRR)
Registration Number
NCT00005765
Locations
🇺🇸

University of Vermont, Burlington, Vermont, United States

Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch)

Phase 4
Completed
Conditions
Alcoholism
Smoking
First Posted Date
2000-02-04
Last Posted Date
2010-09-29
Lead Sponsor
Mayo Clinic
Target Recruit Count
144
Registration Number
NCT00004551
Locations
🇺🇸

Department of Internal Medicine, Mayo Foundation, Rochester, Minnesota, United States

Smoking Cessation in Alcoholism Treatment

Phase 4
Completed
Conditions
Alcoholism
Smoking
First Posted Date
1999-11-03
Last Posted Date
2010-05-19
Lead Sponsor
Yale University
Target Recruit Count
112
Registration Number
NCT00000454
Locations
🇺🇸

Substance Abuse Treatment Center, VA Medical Center, West Haven, Connecticut, United States

Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch)

Phase 4
Completed
Conditions
Alcoholism
Smoking
First Posted Date
1999-11-03
Last Posted Date
2011-02-11
Lead Sponsor
Minneapolis Veterans Affairs Medical Center
Target Recruit Count
500
Registration Number
NCT00000444
Locations
🇺🇸

General Internal Medicine, VA Medical Center, Minneapolis, Minnesota, United States

Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch)

Phase 4
Completed
Conditions
Alcoholism
Smoking
First Posted Date
1999-11-03
Last Posted Date
2010-10-01
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
200
Registration Number
NCT00000447
Locations
🇺🇸

Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, Texas, United States

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