MedPath

Nicotine

Generic Name
Nicotine
Brand Names
Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
Drug Type
Small Molecule
Chemical Formula
C10H14N2
CAS Number
54-11-5
Unique Ingredient Identifier
6M3C89ZY6R
Background

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions
Withdrawal Nicotine
Associated Therapies
Smoking cessation therapy
Clinical Trials
Related News

Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia

Not Applicable
Not yet recruiting
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
Procedure: Carbon Monoxide Measurement
Other: Internet-Based Intervention
Drug: Nicotine Oral Pouch
Drug: Nicotine Lozenge
Other: Survey Administration
Drug: Nicotine Patch
First Posted Date
2025-01-08
Last Posted Date
2025-01-08
Lead Sponsor
Ohio State University Comprehensive Cancer Center
Target Recruit Count
1000
Registration Number
NCT06763536
Locations
🇺🇸

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream

Early Phase 1
Not yet recruiting
Conditions
Cannabis Dependence
Interventions
Procedure: Biospecimen Collection
Drug: Cannabis sativa Extract
Drug: Nicotine
Drug: Placebo Administration
Other: Questionnaire Administration
First Posted Date
2024-03-27
Last Posted Date
2024-03-27
Lead Sponsor
Roswell Park Cancer Institute
Target Recruit Count
60
Registration Number
NCT06334016
Locations
🇺🇸

Roswell Park Cancer Institute, Buffalo, New York, United States

Informing Oral Nicotine Pouch Regulations to Promote Public Health

Phase 2
Recruiting
Conditions
Tobacco-Related Carcinoma
Interventions
Procedure: Biospecimen Collection
Drug: Cigarette
Drug: Nicotine Oral Pouch
Drug: Smokeless Tobacco
Other: Survey Administration
Other: Text Message-Based Navigation Intervention
First Posted Date
2024-03-18
Last Posted Date
2025-01-03
Lead Sponsor
Ohio State University Comprehensive Cancer Center
Target Recruit Count
160
Registration Number
NCT06315881
Locations
🇺🇸

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community

Phase 4
Completed
Conditions
Tobacco Dependence
Interventions
Behavioral: C-Raven Virtual Tobacco Cessation Counseling
Drug: Nicotine Replacement Product
Other: Community Health Worker
Other: Lung Cancer Screening
First Posted Date
2024-03-01
Last Posted Date
2025-01-03
Lead Sponsor
Johns Hopkins University
Target Recruit Count
5
Registration Number
NCT06289192
Locations
🇺🇸

Monument East, Baltimore, Maryland, United States

🇺🇸

Chase House Apartments, Baltimore, Maryland, United States

🇺🇸

Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Nicotine Virtual Reality Conditioned Place Preference

Phase 4
Withdrawn
Conditions
Nicotine Use Disorder
Nicotine Addiction
Interventions
Drug: Nicotine
Drug: Placebo oral capsule
First Posted Date
2024-02-14
Last Posted Date
2024-02-14
Lead Sponsor
University of Chicago
Registration Number
NCT06259630
Locations
🇺🇸

University of Chicago Medical Center - Human Behavioral Pharmacology Lab, Chicago, Illinois, United States

Addictive Threshold of Nicotine

Early Phase 1
Recruiting
Conditions
Smoking Addiction
Interventions
Drug: Nicotine
Other: Saline
First Posted Date
2023-10-24
Last Posted Date
2024-03-06
Lead Sponsor
Yale University
Target Recruit Count
36
Registration Number
NCT06096714
Locations
🇺🇸

VA Healthcare System, West Haven, Connecticut, United States

Nicotine and Pavlovian Bias

Early Phase 1
Recruiting
Conditions
Nicotine Dependence
Nicotine Vaping
Interventions
Other: Placebo
Drug: Nicotine
First Posted Date
2023-09-07
Last Posted Date
2023-11-09
Lead Sponsor
University of Southern California
Target Recruit Count
40
Registration Number
NCT06027723
Locations
🇺🇸

University of Southern California, Los Angeles, California, United States

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

Phase 2
Not yet recruiting
Conditions
Cannabis
THC
Vaping
Cannabis Smoking
Tobacco Use
Cannabis Use
Interventions
Drug: Nicotine
Drug: Cannabis
Device: Pax Loose Leaf Vaporizer
Other: Placebo Marijuana
First Posted Date
2023-08-21
Last Posted Date
2025-01-08
Lead Sponsor
University of California, San Francisco
Target Recruit Count
48
Registration Number
NCT05999383
Locations
🇺🇸

Zuckerberg San Francisco General Hospital, San Francisco, California, United States

Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

Phase 1
Not yet recruiting
Conditions
Nicotine Vaping
Nicotine Dependence
Interventions
Drug: (S)-Nicotine
Drug: (R)- nicotine
Drug: Racemic nicotine
First Posted Date
2023-07-27
Last Posted Date
2024-12-05
Lead Sponsor
University of California, San Francisco
Target Recruit Count
18
Registration Number
NCT05962229
Locations
🇺🇸

Zuckerberg San Francisco General Hospital (ZSFG), San Francisco, California, United States

E-cigarette Nicotine Study

Phase 2
Completed
Conditions
Nicotine Dependence
Electronic Cigarette Use
Cigarette Smoking
Interventions
Drug: Nicotine
Device: Juul e-cigarette
Behavioral: Reduction
First Posted Date
2021-01-14
Last Posted Date
2022-08-26
Lead Sponsor
University of Vermont
Target Recruit Count
77
Registration Number
NCT04709471
Locations
🇺🇸

University of Vermont, Burlington, Vermont, United States

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