Nicotine
- Generic Name
- Nicotine
- Brand Names
- Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
- Drug Type
- Small Molecule
- Chemical Formula
- C10H14N2
- CAS Number
- 54-11-5
- Unique Ingredient Identifier
- 6M3C89ZY6R
- Background
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
- Indication
For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
- Associated Conditions
- Withdrawal Nicotine
- Associated Therapies
- Smoking cessation therapy
E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
- Conditions
- Cigarette SmokingOpioid Use Disorder
- Interventions
- Behavioral: Telehealth Motivational CounselingDevice: National Institute on Drug Abuse (NIDA) Standardized Research Electronic Cigarette (SREC).
- First Posted Date
- 2023-02-10
- Last Posted Date
- 2025-03-18
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 302
- Registration Number
- NCT05722561
- Locations
- 🇺🇸
NYU Langone Health, New York, New York, United States
🇺🇸Albert Einstein College of Medicine, Bronx, New York, United States
Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD
- Conditions
- Tobacco Use Disorder
- Interventions
- Device: sham repetitive transcranial magnetic stimulationDevice: active repetitive transcranial magnetic stimulationBehavioral: cognitive behavioral therapy for smoking cessation
- First Posted Date
- 2023-02-10
- Last Posted Date
- 2025-03-14
- Lead Sponsor
- VA Office of Research and Development
- Target Recruit Count
- 50
- Registration Number
- NCT05723588
- Locations
- 🇺🇸
Durham VA Medical Center, Durham, NC, Durham, North Carolina, United States
Electronic Cigarettes and Nicotine Pouches for Smoking Cessation
- Conditions
- Role of Tobacco Harm Reduction in Smoking CessationEfficiency and Efficacy of E-cigarettes and Nicotine PouchesAdverse Effect of E-cigarettes and Nicotine Pouches
- Interventions
- Device: E-cigarettes device plus liquidOther: Basic care counseling about smoking cessation
- First Posted Date
- 2023-02-06
- Last Posted Date
- 2023-02-06
- Lead Sponsor
- Alternative Research Initiative
- Target Recruit Count
- 600
- Registration Number
- NCT05715164
- Locations
- 🇵🇰
Rawalpindi and Islamabad Centre, Rawalpindi, Punjab, Pakistan
BREATHE 2 Clinic Stop-Smoking Treatment Outreach Study
- Conditions
- Quitting SmokingSmoking CessationSmoking, Cigarette
- Interventions
- Behavioral: Text message smoking treatmentCombination Product: Wisconsin Tobacco QuitLine ReferralCombination Product: Referral to Primary Care ProviderCombination Product: BREATHE 2 Cessation StudyBehavioral: Additional modalities to learn about and request treatment
- First Posted Date
- 2023-01-13
- Last Posted Date
- 2025-04-25
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 12376
- Registration Number
- NCT05683821
- Locations
- 🇺🇸
University of Wisconsin Center for Tobacco Research and Intervention, Madison, Wisconsin, United States
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
- Conditions
- Adverse Childhood ExperiencesNicotine Dependence, Cigarettes
- Interventions
- Drug: Placebo
- First Posted Date
- 2022-12-27
- Last Posted Date
- 2025-04-16
- Lead Sponsor
- Duke University
- Target Recruit Count
- 150
- Registration Number
- NCT05665465
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
QuitAid Pilot Feasibility Trial
- Conditions
- Smoking Cessation
- Interventions
- First Posted Date
- 2022-12-14
- Last Posted Date
- 2022-12-14
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 24
- Registration Number
- NCT05649241
- Locations
- 🇺🇸
University of Virginia, Charlottesville, Virginia, United States
Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)
- Conditions
- Smoking CessationCervical CancerHigh Grade Cervical Dysplasia
- Interventions
- Behavioral: Smoking Cessation treatment delivered by Tobacco Free Florida QuitlineBehavioral: Motivation and Problem Solving (MAPS) intervention
- First Posted Date
- 2022-12-09
- Last Posted Date
- 2025-03-17
- Target Recruit Count
- 360
- Registration Number
- NCT05645146
- Locations
- 🇺🇸
Moffitt Cancer Center, Tampa, Florida, United States
Phone Enabled Implementation of Cessation Support
- Conditions
- Smoking Cessation
- Interventions
- Behavioral: Educational materialsBehavioral: Provider trainingBehavioral: Phone counselingBehavioral: Electronic reminders
- First Posted Date
- 2022-11-28
- Last Posted Date
- 2024-12-09
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 1500
- Registration Number
- NCT05628389
- Locations
- 🇱🇧
American University of Beirut Medical Center, Beirut, Lebanon
Free Samples for Health
- Conditions
- Cigarette Smoking
- Interventions
- Behavioral: Ask-Advise-Refer
- First Posted Date
- 2022-11-25
- Last Posted Date
- 2024-05-30
- Lead Sponsor
- Hennepin Healthcare Research Institute
- Target Recruit Count
- 1200
- Registration Number
- NCT05627596
- Locations
- 🇺🇸
Hennepin Healthcare Research Institute, Minneapolis, Minnesota, United States
Exenatide for Smoking Cessation and Prevention of Weight Gain
- Conditions
- Weight GainSmoking Cessation
- Interventions
- Drug: PlaceboBehavioral: Smoking Cessation Counseling
- First Posted Date
- 2022-11-09
- Last Posted Date
- 2024-12-11
- Target Recruit Count
- 216
- Registration Number
- NCT05610800
- Locations
- 🇺🇸
Michael E. DeBakey VA Medical Center, Houston, Texas, United States
🇺🇸The University of Texas Health Science Center at Houston, Houston, Texas, United States
Drug Development Updates
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