Nicotine

Generic Name
Nicotine
Brand Names
Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
Drug Type
Small Molecule
Chemical Formula
C10H14N2
CAS Number
54-11-5
Unique Ingredient Identifier
6M3C89ZY6R
Background

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions
Withdrawal Nicotine
Associated Therapies
Smoking cessation therapy
Clinical Trials
Related News

Smoking Cessation After Hospitalization for a Cardiopulmonary Illness

Not Applicable
Completed
Conditions
Smoking Cessation
Interventions
Behavioral: hypnotherapy
Drug: Nicotine
First Posted Date
2013-02-15
Last Posted Date
2017-05-19
Lead Sponsor
North Shore Medical Center
Target Recruit Count
164
Registration Number
NCT01791803
Locations
🇺🇸

North Shore Medical Center, Salem, Massachusetts, United States

Nicotine Mouth Film for Craving Relief.

Phase 3
Completed
Conditions
Smoking Cessation
Interventions
Drug: Nicotine
First Posted Date
2012-10-08
Last Posted Date
2014-01-30
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
320
Registration Number
NCT01702532
Locations
🇺🇸

Central Kentucky Research Associates, Inc., Lexington, Kentucky, United States

🇺🇸

Los Angeles Clinical Trials, Burbank, California, United States

A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers

Phase 1
Completed
Conditions
Smoking
Interventions
Drug: nicotine
First Posted Date
2012-10-08
Last Posted Date
2015-03-20
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
40
Registration Number
NCT01702519
Locations
🇺🇸

Celerion NEBRASKA, Lincoln, Nebraska, United States

Pharmacokinetic Study of 4 mg Nicotine Lozenge.

Phase 2
Completed
Conditions
Smoking Cessation
Interventions
Drug: nicotine
First Posted Date
2012-08-20
Last Posted Date
2015-01-22
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
40
Registration Number
NCT01669122
Locations
🇮🇳

Lambda Therapeutic Research Ltd, Ahmedabad, Gujarat, India

The Effect of Smoking on Thermoregulation

Not Applicable
Completed
Conditions
Cigarette Smoking
Interventions
Drug: Nicotine
Other: cigarette smoking
First Posted Date
2012-05-11
Last Posted Date
2014-05-09
Lead Sponsor
Sheba Medical Center
Target Recruit Count
16
Registration Number
NCT01596556
Locations
🇮🇱

The Institute of Military Physiology Heller Institute of Medical Research, Tel-Hashomer Ramat-Gan, Israel

Nicotine Reinforcement and Aversion in Young Adult Light Smokers

Early Phase 1
Completed
Conditions
Nicotine Addiction
Interventions
Drug: Saline
Drug: Nicotine
First Posted Date
2011-12-20
Last Posted Date
2021-08-31
Lead Sponsor
Yale University
Target Recruit Count
34
Registration Number
NCT01495819
Locations
🇺🇸

Department of Veterans Affairs, West Haven, Connecticut, United States

A Smoking Cessation Trial in HIV-infected Patients in South Africa

Not Applicable
Completed
Conditions
Smoking Cessation
HIV
Interventions
Behavioral: Intensive Counseling
Drug: Nicotine
First Posted Date
2011-12-02
Last Posted Date
2019-10-04
Lead Sponsor
Johns Hopkins University
Target Recruit Count
560
Registration Number
NCT01484340
Locations
🇿🇦

Grace Mokhomo Community Health Center, Klerksdorp, North West, South Africa

🇿🇦

Tshepong Wellness Clinic, Klerksdorp, North West, South Africa

🇿🇦

Jouberton Community Health Center, Klerksdorp, North West, South Africa

An Exploratory Study Comparing Two Nicotine Inhalers

Early Phase 1
Completed
Conditions
Tobacco Dependence
Interventions
Drug: Nicotine
First Posted Date
2011-11-23
Last Posted Date
2012-07-10
Lead Sponsor
McNeil AB
Target Recruit Count
36
Registration Number
NCT01478230
Locations
🇸🇪

McNeil AB Clinical Pharmacology R&D, Lund, Sweden

Provoked Craving Relief Study by NRT

Phase 2
Completed
Conditions
Smoking Cessation
Interventions
Drug: nicotine
First Posted Date
2011-11-22
Last Posted Date
2013-09-30
Lead Sponsor
GlaxoSmithKline
Target Recruit Count
120
Registration Number
NCT01476202
Locations
🇺🇸

Central Kentucky Research Associates, Inc., Lexington, Kentucky, United States

Effects of Acute Nicotine Treatment on Neuroplasticity and Memory in Patients With Schizophrenia

First Posted Date
2011-11-04
Last Posted Date
2013-08-13
Lead Sponsor
Centre for Addiction and Mental Health
Target Recruit Count
20
Registration Number
NCT01465074
Locations
🇨🇦

Centre for Addiction and Mental Health, Toronto, Ontario, Canada

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