MedPath

Nicotine

Generic Name
Nicotine
Brand Names
Habitrol, Nicoderm C-Q, Nicorelief, Nicorette, Nicotrol
Drug Type
Small Molecule
Chemical Formula
C10H14N2
CAS Number
54-11-5
Unique Ingredient Identifier
6M3C89ZY6R
Background

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Indication

For the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.

Associated Conditions
Withdrawal Nicotine
Associated Therapies
Smoking cessation therapy
Clinical Trials
Related News

Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Health Staff

Not Applicable
Recruiting
Conditions
Smoking Cessation
Interventions
Drug: Music intervention
First Posted Date
2023-11-14
Last Posted Date
2024-03-01
Lead Sponsor
Poitiers University Hospital
Target Recruit Count
50
Registration Number
NCT06130423
Locations
🇫🇷

CHU Poitiers / CIC, Poitiers, France

The "Quit-for-Kids" Project: to Increase Abstinence and Protect Children from Tobacco Smoke Exposure

Not Applicable
Recruiting
Conditions
Second Hand Tobacco Smoke
Smoking Cessation
Interventions
Behavioral: Brief cessation advice (AWARD)
Behavioral: Environmental assessment derived intervention
Behavioral: Instant messaging Support (IM)
Behavioral: Financial Incentive (FI)
Behavioral: Self-help smoking cessation booklet
First Posted Date
2023-11-13
Last Posted Date
2024-12-09
Lead Sponsor
The University of Hong Kong
Target Recruit Count
1200
Registration Number
NCT06127589
Locations
🇨🇳

The University of Hong Kong, Hong Kong, China

Addictive Threshold of Nicotine

Early Phase 1
Recruiting
Conditions
Smoking Addiction
Interventions
Other: Saline
First Posted Date
2023-10-24
Last Posted Date
2025-04-11
Lead Sponsor
Yale University
Target Recruit Count
36
Registration Number
NCT06096714
Locations
🇺🇸

VA Healthcare System, West Haven, Connecticut, United States

Evaluate Harm Reduction Products As a Second Line Intervention for Adult Smokers Who Do Not Quit with NRT

Phase 3
Terminated
Conditions
Smoking Cessation
Harm Reduction
Interventions
Other: on!
Other: BIDI e-cigarette
First Posted Date
2023-10-18
Last Posted Date
2025-03-30
Lead Sponsor
Rose Research Center, LLC
Target Recruit Count
4
Registration Number
NCT06088862
Locations
🇺🇸

Rose Research Center, Raleigh, North Carolina, United States

Evaluation of the Electronic Cigarette Withdrawal Syndrome

Early Phase 1
Recruiting
Conditions
E-cigarette Use
Withdrawal
Interventions
First Posted Date
2023-10-04
Last Posted Date
2024-11-11
Lead Sponsor
Johns Hopkins University
Target Recruit Count
150
Registration Number
NCT06066996
Locations
🇺🇸

Behavioral Pharmacology Research Unit, Baltimore, Maryland, United States

Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan

Not Applicable
Not yet recruiting
Conditions
Smoking Cessation
Electronic Cigarette Use
Interventions
Device: Electronic Cigarette (EC)
First Posted Date
2023-10-02
Last Posted Date
2024-03-25
Lead Sponsor
Strategic Health Research Limited
Target Recruit Count
438
Registration Number
NCT06063421
Locations
🇵🇰

Health Research Consulting, Islamabad, Pakistan

Community-based Smoking Cessation Treatment for Adults With High Stress Sensitivity.

Phase 3
Recruiting
Conditions
Nicotine Dependence
Interventions
Behavioral: Aerobic Exercise
Behavioral: Counseling
First Posted Date
2023-09-25
Last Posted Date
2025-04-27
Lead Sponsor
Jasper A. Smits
Target Recruit Count
360
Registration Number
NCT06053567
Locations
🇺🇸

University of Texas at Austin, Austin, Texas, United States

Treating Caregivers Who Smoke at AFCH

Phase 4
Recruiting
Conditions
Smoking
Smoking Cessation
Interventions
First Posted Date
2023-09-25
Last Posted Date
2025-03-21
Lead Sponsor
University of Wisconsin, Madison
Target Recruit Count
25
Registration Number
NCT06051474
Locations
🇺🇸

American Family Children's Hospital, Madison, Wisconsin, United States

Nicotine and Pavlovian Bias

Early Phase 1
Recruiting
Conditions
Nicotine Dependence
Nicotine Vaping
Interventions
Other: Placebo
First Posted Date
2023-09-07
Last Posted Date
2023-11-09
Lead Sponsor
University of Southern California
Target Recruit Count
40
Registration Number
NCT06027723
Locations
🇺🇸

University of Southern California, Los Angeles, California, United States

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

Phase 2
Not yet recruiting
Conditions
Cannabis
THC
Vaping
Cannabis Smoking
Tobacco Use
Cannabis Use
Interventions
Device: Pax Loose Leaf Vaporizer
Other: Placebo Marijuana
First Posted Date
2023-08-21
Last Posted Date
2025-04-04
Lead Sponsor
University of California, San Francisco
Target Recruit Count
48
Registration Number
NCT05999383
Locations
🇺🇸

Zuckerberg San Francisco General Hospital, San Francisco, California, United States

© Copyright 2025. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy