The Impact of Dental Health on Complications During and Following Radiotherapy in the Head and Neck Region.

Completed

• Conditions: Head and Neck Neoplasms; Radiotherapy; Complications; Extracting Own Teeth

• Registration Number: NCT06840639
• Lead Sponsor: Lund University Hospital

Brief Summary

Study the risk of complications after dental extractions in patients recieving radiotherapy.

Detailed Description

Dental extractions before radiotherapy in the head and neck region is an established part of the treatment plan for patients with malignant disease. There are contradictory results in the literature regarding the importance timing and magnitude of extractions. It is important to minimize complications in this patient group since the regular therapy is already detrimental to the affected tissues. Patients were extracted from the ARTSCAN register were the population was followed for 4 years for several factors, including development of osteoradionecrosis. The aim is to evaluate which diagnoses are more prone to develop complications after extraction. If there is a relationship between occurrence of complication and magnitude of dental pathology.

Study Timeline

• Study Start: 2024-01-01
• Status Verified: 2024-11
• Study First Submitted: 2024-11-08
• Primary Completion: 2024-12-01
• Study Completion: 2025-01-01
• Study First Submitted QC: 2025-02-20
• Last Update Submitted: 2025-02-20
• Study First Posted: 2025-02-21
• Last Update Posted: 2025-02-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 750

Inclusion Criteria

• Malignant diagnosis
• radiotherapy pre or postoperative

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Does dental extractions increase the risk for complications such as osteoradionecrosis?	From diagnosis of head and neck pathology, approximately 1 month before start of radiotherapy, and to the end of the medical record which may be from one year after the oncologic treatment up to 26 years after oncologic treatment.	Type of complication when extracting teeth in conjunction with radiotherapy.
Does dental pathology in extracted teeth correlate with development of osteoradionecrosis?	From diagnosis of head and neck pathology, approximately 1 month before start of radiotherapy, and to the end of the medical record which may be from one year after the oncologic treatment up to 26 years after oncologic treatment.	Are any specific dental pathology more prone to develop complications than others?

Trial Locations

Locations (1)

Oral and Maxillofacial department; 🇸🇪 Lund, Skåne, Sweden