Analgesic Properties of Nefopam after Uvulopalatopharyngoplasty in patients with obstructive sleep apnea: A Randomized Controlled Trial
Phase 4
Recruiting
- Conditions
- Obstructive sleep apnea patients who undergo uvulopalatoplasty.uvulopalatoplastyobstructive sleep apneanefopampain
- Registration Number
- TCTR20210203007
- Lead Sponsor
- Faculty of Medicine Siriraj Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Body mass index less than 40 kg/m2
Planned for uvulopalatoplasty
Able to handle intravenous patient-controlled analgesia device
Understand Thai language
Intend to participate
Exclusion Criteria
Contraindicated for nefopam i.e. epilepsy, glaucoma, currently on MAO inhibitor drugs or SSRI
Contraindicated to parecoxib i.e. allergy to sulfonamide, ischemic heart disease, previous stroke
Creatinine clearance less than 60 ml/min
Cirrhosis; Child-Pugh class B or C
Allergic to morphine, lidocaine, parecoxib, etericoxib, paracetamol, dexamethasone
Chronic use of opioids or any drug abuse
Chronic use or currently of any analgesic drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Morphine consumption 1 hour milligram of morphine used,Morphine consumption 2 hour milligram of morphine used,Morphine consumption 6 hour milligram of morphine used,Morphine consumption 12 hour milligram of morphine used,Morphine consumption 18 hour milligram of morphine used,Morphine consumption 24 hour milligram of morphine used
- Secondary Outcome Measures
Name Time Method