Bloodflow Restricted Exercise in Healthy Ageing
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Muscle fibre cross sectional area (CSA)
研究概览
简要总结
The overall objective of this study is to investigate the efficacy of low-intensity blood flow restricted resistance exercise (BFRRE) to promote health beneficial skeletal muscle adaptations and augment muscle function in a healthy older population. This objective will be achieved by in-dept evaluation of skeletal muscle cellular and functional characteristics prior to and after an intervention period comprising 6 weeks of BFRRE or non-exercise control intervention in healthy older subjects. A special focus is placed on the ability of BFRRE to stimulate skeletal muscle protein synthesis and augment muscle stem cell function.
Furthermore, recent findings suggests that similar exercise interventions in a population of patients with heart failure (HF) does not stimulate the desired adaptations. In accordance, we aim to compare the adaptive response to BFRRE amongst HF patients and the enrolled age-matched healthy individuals from the present investigation.
The findings of the current study will expand our understanding of how low-intensity resistance exercise alternatives might be viable in promoting muscle anabolism to combat the loss of muscle mass observed with ageing as well as the potential anabolic resistance accompanying HF diagnosis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to understand the written and spoken information and to give informed consent for inclusion.
- •Age between 45 and 80 years
- •Able to sit in a knee extension machine
- •Able to deliver muscle biopsies
- •Able to train 3 times per week during a 6-week period
排除标准
- •Known history of cardiac disease
- •Habitual exercise with high intensity > 2 times pr. week within the past 6 months
- •Pregnancy
- •Diabetes mellitus
- •Peripheral neuropathy
- •Dialysis treatment
- •Severe peripheral arterial disease
- •Concomitant acute life threatening medical condition
- •Intracranial aneurisms, arteriovenous malformation, cerebral neoplasm or abscess
- •Severe arterial hypertension (≥ 180/≥ 110 mmHg) or moderate arterial hypertension (160-179/100-109) despite medical treatment
- •Moderate or severe chronic obstructive pulmonary disease
- •Decreased kidney function - eGFR < 60 ml/min
结局指标
主要结局
Muscle fibre cross sectional area (CSA)
时间窗: 6 weeks
Histological examination of muscle biopsies
Segmental muscle mass of lower extremity
时间窗: 6 weeks
Dual Energi X-ray Absorption (DEXA)
Subfractional muscle protein synthesis rates
时间窗: 6 weeks
Myofibrillar protein synthesis rate
Muscle stem cell function
时间窗: 6 weeks
Time to first division
次要结局
- Maximal Voluntary Contraction (MVC)(6 weeks)
- Muscle strength-endurance capacity(6 weeks)
- 1 repetition maximum(6 weeks)