A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER)
- Conditions
- Chronic Obstructive Pulmonary Disease
- Interventions
- Drug: Placebo
- Registration Number
- NCT04636801
- Lead Sponsor
- Chiesi Farmaceutici S.p.A.
- Brief Summary
The purpose of the study is to evaluate the efficacy and safety of two doses of CHF6001 (Tanimilast), as add-on to maintenance triple therapy in the target patient population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 3435
- Adults aged ≥ 40 years with COPD and chronic bronchitis
- Current or ex-smokers (history ≥ 10 pack years).
- Post-bronchodilator FEV1 <60% of the subject predicted normal value and FEV1/FVC ratio < 0.7.
- At least, one moderate or severe COPD exacerbation in previous year.
- CAT score ≥ 10
- Subjects on regular maintenance triple therapy for at least 12 months prior to screening and receiving regular maintenance triple therapy for at least 3 months prior to screening visit
- Subjects with current asthma.
- Subjects with moderate or severe COPD exacerbation 4 weeks prior to study entry and randomization.
- Subjects with known α-1 antitrypsin deficiency as the underlying cause of COPD.
- Subjects with COPD emphysema or mixed phenotypes.
- Subjects with known respiratory disorders other than COPD.
- Subjects with active cancer or a history of lung cancer with full recovery less than 1 year after completing cancer therapy.
- Subjects under Roflumilast treatment within 6 months before study entry.
- Subjects with a diagnosis of depression, generalised anxiety disorder, suicidal ideation.
- Subjects with clinically significant cardiovascular.
- Subjects with a significant neurological disease.
- Subjects with clinically significant laboratory abnormalities.
- Subjects with moderate or severe hepatic impairment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CHF6001 Placebo Placebo -
- Primary Outcome Measures
Name Time Method The number of moderate and severe COPD exacerbations occurring during the planned 52-week treatment period. Up to 52 weeks Moderate or severe exacerbation is defined by symptomatic worsening of COPD:
* Moderate: requiring use of systemic corticosteroid (oral/IV/IM corticosteroids), and/or use of antibiotics
* Severe: requiring hospitalisation or resulting in death
- Secondary Outcome Measures
Name Time Method The annual rate of severe exacerbation. Up to 52 weeks The time to first severe exacerbation. Up to 52 weeks The time to first moderate or severe exacerbation. Up to 52 weeks The number of on-treatment severe exacerbations. Up to 52 weeks SGRQ response (change from baseline SGRQ total score ≤ -4) at week 52. At week 52 Change from baseline to last inter-visit period (week 40-52) in E-RS Total and subscale scores Up to 52 weeks E-RS response (change from baseline E-RS Total score ≤ -2) at week 52. At week 52 Change from baseline to last inter-visit period (week 40-52) in the percentage of days without intake of rescue medication and in the average rescue medication use (number of puffs) Up to 52 weeks Time to study medication discontinuation for any reason. Up to 52 weeks Time to moderate or severe exacerbation or study medication discontinuation due to any adverse event, lack of efficacy or death (composite endpoint) and time to study medication discontinuation component. Up to 52 weeks Change from baseline (pre-dose visit 2) in pre-dose FEV1 at week 52. At Week 52 Change from baseline in SGRQ total and domain scores at week 52. At week 52
Trial Locations
- Locations (447)
Chiesi Clinical Trial - Site 840402
🇺🇸Sheffield, Alabama, United States
Chiesi Clinical Trial - Site 840480
🇺🇸Northridge, California, United States
Chiesi Clinical Trial - Site 840487
🇺🇸Cutler Bay, Florida, United States
Chiesi Clinical Trial - Site 840404
🇺🇸Hollywood, Florida, United States
Chiesi Clinical Trial - Site 840407
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840444
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840437
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840403
🇺🇸Miami, Florida, United States
Chiesi Clinical Trial - Site 840463
🇺🇸Orlando, Florida, United States
Chiesi Clinical Trial - Site 840401
🇺🇸Peachtree Corners, Georgia, United States
Chiesi Clinical Trial - Site 840478
🇺🇸New Windsor, New York, United States
Chiesi Clinical Trial - Site 840483
🇺🇸Philadelphia, Pennsylvania, United States
Chiesi Clinical Trial - Site 840474
🇺🇸Kerrville, Texas, United States
Chiesi Clinical Trial - Site 840409
🇺🇸Plano, Texas, United States
Chiesi Clinical Trial - Site 840481
🇺🇸San Antonio, Texas, United States
Chiesi Clinical Trial - Site 8455
🇦🇱Durres, Albania
Chiesi Clinical Trial - Site 8459
🇦🇱Durres, Albania
Chiesi Clinical Trial - Site 8457
🇦🇱Elbasan, Albania
Chiesi Clinical Trial - Site 8460
🇦🇱Korca, Albania
Chiesi Clinical Trial - Site 8451
🇦🇱Tirana, Albania
Chiesi Clinical Trial - Site 8452
🇦🇱Tirana, Albania
Chiesi Clinical Trial - Site 8453
🇦🇱Tirana, Albania
Chiesi Clinical Trial - Site 8454
🇦🇱Tirana, Albania
Chiesi Clinical Trial - Site 8456
🇦🇱Tirana, Albania
Chiesi Clinical Trial - Site 8458
🇦🇱Tirana, Albania
Chiesi Clinical Trial - Site 32415
🇦🇷Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32407
🇦🇷Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32410
🇦🇷Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32454
🇦🇷Buenos Aires, Argentina
Chiesi Clinical Trial - Site 32457
🇦🇷Caba, Argentina
Chiesi Clinical Trial - Site 32459
🇦🇷Caba, Argentina
Chiesi Clinical Trial - Site 32414
🇦🇷Ciudad Autonoma de Buenos Aire, Argentina
Chiesi Clinical Trial - Site 32403
🇦🇷Córdoba, Argentina
Chiesi Clinical Trial - Site 32409
🇦🇷Córdoba, Argentina
Chiesi Clinical Trial - Site 32408
🇦🇷Florencio Varela, Argentina
Chiesi Clinical Trial - Site 32401
🇦🇷Florida, Argentina
Centro de Medicina Respiratoria - Concepcion del Uruguay - site 32463
🇦🇷Forestal Entre Ríos, Argentina
Chiesi Clinical Trial - Site 32455
🇦🇷La Plata, Argentina
Chiesi Clinical Trial - Site 32458
🇦🇷Mar Del Plata, Argentina
Chiesi Clinical Trial - Site 32462
🇦🇷Mar Del Plata, Argentina
Chiesi Clinical Trial - Site 32405
🇦🇷Mendoza, Argentina
Chiesi Clinical Trial - Site 32411
🇦🇷Mendoza, Argentina
Chiesi Clinical Trial - Site 32413
🇦🇷Mendoza, Argentina
Chiesi Clinical Trial - Site 32402
🇦🇷Monte Grande, Argentina
Chiesi Clinical Trial - Site 32406
🇦🇷Quilmes, Argentina
Chiesi Clinical Trial - Site 32453
🇦🇷Rosario, Argentina
Chiesi Clinical Trial - Site 32460
🇦🇷San Fernando, Argentina
Chiesi Clinical Trial - Site 32412
🇦🇷San Miguel De Tucumán, Argentina
Chiesi Clinical Trial - Site 32451
🇦🇷San Miguel De Tucumán, Argentina
Chiesi Clinical Trial - Site 32452
🇦🇷San Miguel de Tucumán, Argentina
Chiesi Clinical Trial - Site 32461
🇦🇷San Miguel de Tucumán, Argentina
Chiesi Clinical Trial - Site 32464
🇦🇷San Miguel De Tucumán, Argentina
Chiesi Clinical Trial - Site 32456
🇦🇷Santa Fe, Argentina
Chiesi Clinical Trial - Site 36453
🇦🇺Adelaide, Australia
Chiesi Clinical Trial - Site 36454
🇦🇺Box Hill, Australia
Chiesi Clinical Trial - Site 36455
🇦🇺Campbelltown, Australia
Chiesi Clinical Trial - Site 36456
🇦🇺Clayton, Australia
Chiesi Clinical Trial - Site 36451
🇦🇺South Brisbane, Australia
Chiesi Clinical Trial - Site 36452
🇦🇺Westmead, Australia
Chiesi Clinical Trial - Site 40402
🇦🇹Feldbach, Austria
Chiesi Clinical Trial - Site 40404
🇦🇹Grieskirchen, Austria
Chiesi Clinical Trial - Site 40406
🇦🇹Linz, Austria
Chiesi Clinical Trial - Site 40401
🇦🇹Linz, Austria
Chiesi Clinical Trial - Site 40403
🇦🇹Linz, Austria
Chiesi Clinical Trial - Site 40405
🇦🇹Wels, Austria
Chiesi Clinical Trial - Site 070401
🇧🇦Banja Luka, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 070407
🇧🇦Doboj, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 070460
🇧🇦Mostar, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 070404
🇧🇦Pale, Bosnia and Herzegovina
OJ Dom zdravlja Novo Sarajevo "Omer Maslić" - Site 70408
🇧🇦Sarajevo, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 070405
🇧🇦Sarajevo, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 070406
🇧🇦Sarajevo, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 070403
🇧🇦Tesanj, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 070402
🇧🇦Tuzla, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 070463
🇧🇦Tuzla, Bosnia and Herzegovina
Chiesi Clinical Trial - Site 100435
🇧🇬Blagoevgrad, Bulgaria
Chiesi Clinical Trial - Site 100434
🇧🇬Dimitrovgrad, Bulgaria
Chiesi Clinical Trial - Site 100453
🇧🇬Gabrovo, Bulgaria
Chiesi Clinical Trial - Site 100423
🇧🇬Haskovo, Bulgaria
Chiesi Clinical Trial - Site 100433
🇧🇬Kozloduy, Bulgaria
Chiesi Clinical Trial - Site 100455
🇧🇬Lovech, Bulgaria
Chiesi Clinical Trial - Site 100415
🇧🇬Montana, Bulgaria
Chiesi Clinical Trial - Site 100432
🇧🇬Pernik, Bulgaria
Chiesi Clinical Trial - Site 100422
🇧🇬Pleven, Bulgaria
Chiesi Clinical Trial - Site 100452
🇧🇬Plovdiv, Bulgaria
Chiesi Clinical Trial - Site 100456
🇧🇬Plovdiv, Bulgaria
Chiesi Clinical Trial - Site 100437
🇧🇬Razgrad, Bulgaria
Chiesi Clinical Trial - Site 100412
🇧🇬Ruse, Bulgaria
Chiesi Clinical Trial - Site 100416
🇧🇬Ruse, Bulgaria
Chiesi Clinical Trial - Site 100436
🇧🇬Sevlievo, Bulgaria
Chiesi Clinical Trial - Site 100460
🇧🇬Sliven, Bulgaria
Chiesi Clinical Trial - Site 100409
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100414
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100417
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100418
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100420
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100430
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100431
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100438
🇧🇬Sofia, Bulgaria
Chiesi Clinical Trial - Site 100424
🇧🇬Stara Zagora, Bulgaria
Chiesi Clinical Trial - Site 100454
🇧🇬Stara Zagora, Bulgaria
Chiesi Clinical Trial - Site 100462
🇧🇬Veliko Tarnovo, Bulgaria
Chiesi Clinical Trial - Site 100419
🇧🇬Vidin, Bulgaria
Chiesi Clinical Trial - Site 100457
🇧🇬Vidin, Bulgaria
Chiesi Clinical Trial - Site 152406
🇨🇱Concepcion, Chile
Chiesi Clinical Trial - Site 152407
🇨🇱Quillota, Chile
Chiesi Clinical Trial - Site 152403
🇨🇱Santiago, Chile
Chiesi Clinical Trial - Site 152404
🇨🇱Santiago, Chile
Chiesi Clinical Trial - Site 152409
🇨🇱Talca, Chile
Chiesi Clinical Trial - Site 152401
🇨🇱Valparaiso, Chile
Chiesi Clinical Trial - Site 156473
🇨🇳Baotou, China
Chiesi Clinical Trial - Site 156507
🇨🇳Baotou, China
Chiesi Clinical Trial - Site 156474
🇨🇳Beijing, China
Chiesi Clinical Trial - Site 156489
🇨🇳Beijing, China
Chiesi Clinical Trial - Site 156509
🇨🇳Beijing, China
Chiesi Clinical Trial - Site 156501
🇨🇳Changchun, China
Chiesi Clinical Trial - Site 156455
🇨🇳Changsha, China
Chiesi Clinical Trial - Site 156488
🇨🇳Changsha, China
Chiesi Clinical Trial - Site 156451
🇨🇳Chengdu, China
Chiesi Clinical Trial - Site 156490
🇨🇳Chengdu, China
Chiesi Clinical Trial - Site 156463
🇨🇳Chongqing, China
Chiesi Clinical Trial - Site 156511
🇨🇳Chongqing, China
Chiesi Clinical Trial - Site 156452
🇨🇳Guangzhou, China
Chiesi Clinical Trial - Site 156460
🇨🇳Guangzhou, China
Chiesi Clinical Trial - Site 156471
🇨🇳Guangzhou, China
Chiesi Clinical Trial - Site 156472
🇨🇳Guangzhou, China
Chiesi Clinical Trial - Site 156494
🇨🇳Guangzhou, China
Chiesi Clinical Trial - Site 156504
🇨🇳Guangzhou, China
Chiesi Clinical Trial - Site 156468
🇨🇳Haikou, China
Chiesi Clinical Trial - Site 156498
🇨🇳Hangzhou, China
Chiesi Clinical Trial - Site 156510
🇨🇳Harbin, China
Chiesi Clinical Trial - Site 156486
🇨🇳Hefei, China
Chiesi Clinical Trial - Site 156503
🇨🇳Hefei, China
Chiesi Clinical Trial - Site 156483
🇨🇳Hengyang, China
Chiesi Clinical Trial - Site 156512
🇨🇳Hohhot, China
Chiesi Clinical Trial - Site 156495
🇨🇳Huanghou, China
Chiesi Clinical Trial - Site 156506
🇨🇳Huizhou, China
Chiesi Clinical Trial - Site 156456
🇨🇳Jinan, China
Chiesi Clinical Trial - Site 156485
🇨🇳Jinhua, China
Chiesi Clinical Trial - Site 156454
🇨🇳Liaoyang, China
Chiesi Clinical Trial - Site 156453
🇨🇳Nanchang, China
Chiesi Clinical Trial - Site 156467
🇨🇳Nanchang, China
Chiesi Clinical Trial - Site 156484
🇨🇳Nanjing, China
Chiesi Clinical Trial - Site 156496
🇨🇳Nanjing, China
Chiesi Clinical Trial - Site 156497
🇨🇳Nanjing, China
Chiesi Clinical Trial - Site 156481
🇨🇳Pingxiang, China
Chiesi Clinical Trial - Site 156464
🇨🇳Qingyuan, China
Chiesi Clinical Trial - Site 156458
🇨🇳Shanghai, China
Chiesi Clinical Trial - Site 156461
🇨🇳Shanghai, China
Chiesi Clinical Trial - Site 156475
🇨🇳Shanghai, China
Chiesi Clinical Trial - Site 156476
🇨🇳Shanghai, China
Chiesi Clinical Trial - Site 156477
🇨🇳Shanghai, China
Chiesi Clinical Trial - Site 156487
🇨🇳Shanghai, China
Chiesi Clinical Trial - Site 156457
🇨🇳Suzhou, China
Chiesi Clinical Trial - Site 156499
🇨🇳Taiyuan, China
Chiesi Clinical Trial - Site 156469
🇨🇳Taizhou, China
Chiesi Clinical Trial - Site 156465
🇨🇳Tianjin, China
Chiesi Clinical Trial - Site 156480
🇨🇳Tianjin, China
Chiesi Clinical Trial - Site 156491
🇨🇳Wuhan, China
Chiesi Clinical Trial - Site 156505
🇨🇳Wuhan, China
Chiesi Clinical Trial - Site 156492
🇨🇳Wuxi, China
Chiesi Clinical Trial - Site 156493
🇨🇳Wuxi, China
Chiesi Clinical Trial - Site 156470
🇨🇳Xiangtan, China
Chiesi Clinical Trial - Site 156482
🇨🇳Xining, China
Chiesi Clinical Trial - Site 156478
🇨🇳Xinxiang, China
Chiesi Clinical Trial - Site 156466
🇨🇳Xuzhou, China
Chiesi Clinical Trial - Site 156479
🇨🇳Xuzhou, China
Chiesi Clinical Trial - Site 156508
🇨🇳Yanji, China
Chiesi Clinical Trial - Site 156459
🇨🇳Yiyang, China
Chiesi Clinical Trial - Site 156462
🇨🇳Zhanjiang, China
Chiesi Clinical Trial - Site 203406
🇨🇿Brandys nad Labem, Czechia
Chiesi Clinical Trial - Site 203418
🇨🇿Havlickuv Brod, Czechia
Chiesi Clinical Trial - Site 203401
🇨🇿Jindrichuv Hradec, Czechia
Chiesi Clinical Trial - Site 203410
🇨🇿Lovosice, Czechia
Chiesi Clinical Trial - Site 203417
🇨🇿Mesice, Czechia
Chiesi Clinical Trial - Site 203404
🇨🇿Miroslav, Czechia
Chiesi Clinical Trial - Site 203416
🇨🇿Mlada Boleslav, Czechia
Chiesi Clinical Trial - Site 203453
🇨🇿Olomouc, Czechia
Chiesi Clinical Trial - Site 203452
🇨🇿Prague, Czechia
Chiesi Clinical Trial - Site 203405
🇨🇿Praha, Czechia
Chiesi Clinical Trial - Site 203407
🇨🇿Praha, Czechia
Chiesi Clinical Trial - Site 203413
🇨🇿Praha, Czechia
Chiesi Clinical Trial - Site 203415
🇨🇿Praha, Czechia
Chiesi Clinical Trial - Site 203402
🇨🇿Strakonice, Czechia
Chiesi Clinical Trial - Site 203451
🇨🇿Tabor, Czechia
Chiesi Clinical Trial - Site 203412
🇨🇿Varnsdorf, Czechia
Chiesi Clinical Trial - Site 268451
🇬🇪Tbilisi, Georgia
Chiesi Clinical Trial - Site 268452
🇬🇪Tbilisi, Georgia
Chiesi Clinical Trial - Site 268453
🇬🇪Tbilisi, Georgia
Chiesi Clinical Trial - Site 268454
🇬🇪Tbilisi, Georgia
Chiesi Clinical Trial - Site 268455
🇬🇪Tbilisi, Georgia
Chiesi Clinical Trial - Site 268456
🇬🇪Tbilisi, Georgia
Chiesi Clinical Trial - Site 268457
🇬🇪Tbilisi, Georgia
Chiesi Clinical Trial - Site 276462
🇩🇪Bamberg, Germany
Chiesi Clinical Trial - Site 276405
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276406
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276410
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276411
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276415
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276452
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276453
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276457
🇩🇪Berlin, Germany
Chiesi Clinical Trial - Site 276456
🇩🇪Cottbus, Germany
Chiesi Clinical Trial - Site 276409
🇩🇪Darmstadt, Germany
Chiesi Clinical Trial - Site 276403
🇩🇪Delitzsch, Germany
Chiesi Clinical Trial - Site 276455
🇩🇪Essen, Germany
Chiesi Clinical Trial - Site 276404
🇩🇪Frankfurt, Germany
Chiesi Clinical Trial - Site 276401
🇩🇪Hamburg, Germany
Chiesi Clinical Trial - Site 276413
🇩🇪Hamburg, Germany
Chiesi Clinical Trial - Site 276463
🇩🇪Hannover, Germany
Chiesi Clinical Trial - Site 276417
🇩🇪Koblenz, Germany
Chiesi Clinical Trial - Site 276402
🇩🇪Leipzig, Germany
Chiesi Clinical Trial - Site 276416
🇩🇪Leipzig, Germany
Chiesi Clinical Trial - Site 276461
🇩🇪Leipzig, Germany
Chiesi Clinical Trial - Site 276407
🇩🇪Mainz, Germany
Chiesi Clinical Trial - Site 276408
🇩🇪Munich, Germany
Chiesi Clinical Trial - Site 276459
🇩🇪Münster, Germany
Chiesi Clinical Trial - Site 276418
🇩🇪Peine, Germany
Chiesi Clinical Trial - Site 276464
🇩🇪Schleswig, Germany
Chiesi Clinical Trial - Site 300406
🇬🇷Athens, Greece
Chiesi Clinical Trial - Site 300401
🇬🇷Heraklion, Greece
Chiesi Clinical Trial - Site 300403
🇬🇷Ioannina, Greece
Chiesi Clinical Trial - Site 300404
🇬🇷Thessaloniki, Greece
Chiesi Clinical Trial - Site 300405
🇬🇷Thessaloniki, Greece
Chiesi Clinical Trial - Site 300407
🇬🇷Volos, Greece
Chiesi Clinical Trial - Site 348406
🇭🇺Balassagyarmat, Hungary
Chiesi Clinical Trial - Site 348401
🇭🇺Budapest, Hungary
Chiesi Clinical Trial - Site 348457
🇭🇺Budapest, Hungary
Chiesi Clinical Trial - Site 348459
🇭🇺Budapest, Hungary
Chiesi Clinical Trial - Site 348405
🇭🇺Csorna, Hungary
Chiesi Clinical Trial - Site 348412
🇭🇺Edelény, Hungary
Chiesi Clinical Trial - Site 348408
🇭🇺Godollo, Hungary
Chiesi Clinical Trial - Site 348451
🇭🇺Gyula, Hungary
Chiesi Clinical Trial - Site 348409
🇭🇺Monor, Hungary
Chiesi Clinical Trial - Site 348407
🇭🇺Nyíregyháza, Hungary
Chiesi Clinical Trial - Site 348413
🇭🇺Pécs, Hungary
Chiesi Clinical Trial - Site 348452
🇭🇺Sellye, Hungary
Chiesi Clinical Trial - Site 348410
🇭🇺Szeged, Hungary
Chiesi Clinical Trial - Site 348461
🇭🇺Szolnok, Hungary
Chiesi Clinical Trial - Site 348403
🇭🇺Szombathely, Hungary
Chiesi Clinical Trial - Site 348458
🇭🇺Százhalombatta, Hungary
Chiesi Clinical Trial - Site 348453
🇭🇺Tatabanya, Hungary
Chiesi Clinical Trial - Site 348415
🇭🇺Törökbálint, Hungary
Chiesi Clinical Trial - Site 376402
🇮🇱Ashkelon, Israel
Chiesi Clinical Trial - Site 376401
🇮🇱Be'er Sheva, Israel
Chiesi Clinical Trial - Site 376408
🇮🇱Haifa, Israel
Chiesi Clinical Trial - Site 376403
🇮🇱Jerusalem, Israel
Chiesi Clinical Trial - Site 376406
🇮🇱Jerusalem, Israel
Chiesi Clinical Trial - Site 376407
🇮🇱Kfar Saba, Israel
Chiesi Clinical Trial - Site 376405
🇮🇱Petach Tikva, Israel
Chiesi Clinical Trial - Site 376404
🇮🇱Ramat Gan, Israel
Chiesi Clinical Trial - Site 376451
🇮🇱Tel HaShomer, Israel
Chiesi Clinical Trial - Site 376409
🇮🇱Tel-Aviv, Israel
Chiesi Clinical Trial - Site 380454
🇮🇹Brescia, Italy
Chiesi Clinical Trial - Site 380451
🇮🇹Catania, Italy
Chiesi Clinical Trial - Site 380453
🇮🇹Ferrara, Italy
Chiesi Clinical Trial - Site 380455
🇮🇹Roma, Italy
Chiesi Clinical Trial - Site 380452
🇮🇹Trieste, Italy
Chiesi Clinical Trial - Site 484402
🇲🇽Chihuahua, Mexico
Chiesi Clinical Trial - Site 484410
🇲🇽Chihuahua, Mexico
Chiesi Clinical Trial - Site 484406
🇲🇽Ciudad de Mexico, Mexico
Chiesi Clinical Trial - Site 484405
🇲🇽Cordoba, Mexico
Chiesi Clinical Trial - Site 484452
🇲🇽Durango, Mexico
Chiesi Clinical Trial - Site 484401
🇲🇽Guadalajara, Mexico
Chiesi Clinical Trial - Site 484407
🇲🇽Guadalajara, Mexico
Chiesi Clinical Trial - Site 484409
🇲🇽Guadalajara, Mexico
Chiesi Clinical Trial - Site 484453
🇲🇽Guadalajara, Mexico
Chiesi Clinical Trial - Site 484403
🇲🇽Monterrey, Mexico
Chiesi Clinical Trial - Site 484411
🇲🇽Monterrey, Mexico
Chiesi Clinical Trial - Site 484404
🇲🇽Veracruz, Mexico
Chiesi Clinical Trial - Site 528403
🇳🇱Almere, Netherlands
Chiesi Clinical Trial - Site 528401
🇳🇱Beek, Netherlands
Chiesi Clinical Trial - Site 528404
🇳🇱Breda, Netherlands
Chiesi Clinical Trial - Site 528402
🇳🇱Heerlen, Netherlands
Chiesi Clinical Trial - Site 528405
🇳🇱Leeuwarden, Netherlands
Chiesi Clinical Trial - Site 554404
🇳🇿Christchurch, New Zealand
Chiesi Clinical Trial - Site 554402
🇳🇿Hamilton, New Zealand
Chiesi Clinical Trial - Site 554406
🇳🇿Wellington, New Zealand
Chiesi Clinical Trial - Site 807402
🇲🇰Gostivar, North Macedonia
Chiesi Clinical Trial - Site 807401
🇲🇰Prilep, North Macedonia
Chiesi Clinical Trial - Site 807452
🇲🇰Skopje, North Macedonia
Chiesi Clinical Trial - Site 807454
🇲🇰Skopje, North Macedonia
General Hospital-Struga - Site 807405
🇲🇰Struga, North Macedonia
General Hospital-Strumica - Site 807406
🇲🇰Strumica, North Macedonia
Chiesi Clinical Trial - Site 807403
🇲🇰Tetovo, North Macedonia
General Hospital - Veles - Site 807404
🇲🇰Veles, North Macedonia
Chiesi Clinical Trial - Site 616413
🇵🇱Bialystok, Poland
Chiesi Clinical Trial - Site 616418
🇵🇱Bialystok, Poland
HolsaClinical - Gyncentrum Bielsko-Biala - Site 616460
🇵🇱Bielsko-Biala, Poland
Chiesi Clinical Trial - Site 616404
🇵🇱Gizycko, Poland
Chiesi Clinical Trial - Site 616415
🇵🇱Katowice, Poland
Chiesi Clinical Trial - Site 616422
🇵🇱Katowice, Poland
Chiesi Clinical Trial - Site 616409
🇵🇱Krakow, Poland
Chiesi Clinical Trial - Site 616411
🇵🇱Krakow, Poland
Chiesi Clinical Trial - Site 616414
🇵🇱Krakow, Poland
Chiesi Clinical Trial - Site 616455
🇵🇱Krakow, Poland
Chiesi Clinical Trial - Site 616458
🇵🇱Lodz, Poland
Chiesi Clinical Trial - Site 616457
🇵🇱Lublin, Poland
Chiesi Clinical Trial - Site 616419
🇵🇱Ostrowiec, Poland
Chiesi Clinical Trial - Site 616456
🇵🇱Piaseczno, Poland
Chiesi Clinical Trial - Site 616406
🇵🇱Poznan, Poland
Chiesi Clinical Trial - Site 616408
🇵🇱Poznan, Poland
Chiesi Clinical Trial - Site 616401
🇵🇱Sosnowiec, Poland
Chiesi Clinical Trial - Site 616451
🇵🇱Tarnow, Poland
Chiesi Clinical Trial - Site 616402
🇵🇱Torun, Poland
Chiesi Clinical Trial - Site 616452
🇵🇱Wroclaw, Poland
Chiesi Clinical Trial - Site 616454
🇵🇱Wroclaw, Poland
AmiCare Medical Centre - Site 616459
🇵🇱Łódź, Poland
Chiesi Clinical Trial - Site 616403
🇵🇱Łódź, Poland
Chiesi Clinical Trial - Site 616423
🇵🇱Łódź, Poland
Chiesi Clinical Trial - Site 642410
🇷🇴Bacau, Romania
Chiesi Clinical Trial - Site 642452
🇷🇴Bragadiru, Romania
Chiesi Clinical Trial - Site 642402
🇷🇴Cluj-Napoca, Romania
Chiesi Clinical Trial - Site 642404
🇷🇴Cluj-Napoca, Romania
Chiesi Clinical Trial - Site 642406
🇷🇴Cluj-Napoca, Romania
Chiesi Clinical Trial - Site 642408
🇷🇴Cluj-Napoca, Romania
Chiesi Clinical Trial - Site 642454
🇷🇴Cluj-Napoca, Romania
Chiesi Clinical Trial - Site 642412
🇷🇴Cluj, Romania
Chiesi Clinical Trial - Site 642401
🇷🇴Constanța, Romania
Chiesi Clinical Trial - Site 642409
🇷🇴Craiova, Romania
Chiesi Clinical Trial - Site 642411
🇷🇴Craiova, Romania
Chiesi Clinical Trial - Site 642453
🇷🇴Deva, Romania
Chiesi Clinical Trial - Site 642414
🇷🇴Iasi, Romania
Chiesi Clinical Trial - Site 642403
🇷🇴Oradea, Romania
Chiesi Clinical Trial - Site 642413
🇷🇴Resca, Romania
Chiesi Clinical Trial - Site 642407
🇷🇴Timisoara, Romania
Chiesi Clinical Trial - Site 642405
🇷🇴Timișoara, Romania
Chiesi Clinical Trial - Site 642415
🇷🇴Timișoara, Romania
Chiesi Clinical Trial - Site 643433
🇷🇺Chelyabinsk, Russian Federation
Chiesi Clinical Trial - Site 643417
🇷🇺Kazan, Russian Federation
Chiesi Clinical Trial - Site 643462
🇷🇺Kazan, Russian Federation
Chiesi Clinical Trial - Site 643456
🇷🇺Kemerovo, Russian Federation
Chiesi Clinical Trial - Site 643401
🇷🇺Moscow, Russian Federation
Chiesi Clinical Trial - Site 643413
🇷🇺Moscow, Russian Federation
Chiesi Clinical Trial - Site 643428
🇷🇺Moscow, Russian Federation
Chiesi Clinical Trial - Site 643460
🇷🇺Moscow, Russian Federation
Chiesi Clinical Trial - Site 643454
🇷🇺Moskva, Russian Federation
Chiesi Clinical Trial - Site 643416
🇷🇺Nizhny Novgorod, Russian Federation
Chiesi Clinical Trial - Site 643403
🇷🇺Odintsovskiy, Russian Federation
Chiesi Clinical Trial - Site 643457
🇷🇺Rostov-na-Donu, Russian Federation
Chiesi Clinical Trial - Site 643459
🇷🇺Rostov-on-Don, Russian Federation
Chiesi Clinical Trial - Site 643404
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643406
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643408
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643414
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643423
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643424
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643431
🇷🇺Saint Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643451
🇷🇺Saint-Peterburg, Russian Federation
Chiesi Clinical Trial - Site 643405
🇷🇺Saint-Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643410
🇷🇺Saint-Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643412
🇷🇺Saint-Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643420
🇷🇺Saint-Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643458
🇷🇺Sankt-Peterburg, Russian Federation
Chiesi Clinical Trial - Site 643415
🇷🇺Saratov, Russian Federation
Chiesi Clinical Trial - Site 643425
🇷🇺Saratov, Russian Federation
Chiesi Clinical Trial - Site 643411
🇷🇺St. Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643419
🇷🇺St. Petersburg, Russian Federation
Chiesi Clinical Trial - Site 643421
🇷🇺Ulyanovsk, Russian Federation
Chiesi Clinical Trial - Site 643402
🇷🇺Voronezh, Russian Federation
Chiesi Clinical Trial - Site 643426
🇷🇺Yaroslavl', Russian Federation
Chiesi Clinical Trial - Site 643407
🇷🇺Yaroslavl, Russian Federation
Chiesi Clinical Trial - Site 643418
🇷🇺Yaroslavl, Russian Federation
Kliničko Bolnički Centar Zvezdara - Site 688459
🇷🇸Belgrade, Serbia
Chiesi Clinical Trial - Site 688401
🇷🇸Belgrade, Serbia
Klinički Centar Kragujevac - Site 688456
🇷🇸Kragujevac, Serbia
Chiesi Clinical Trial - Site 688402
🇷🇸Kragujevac, Serbia
Chiesi Clinical Trial - Site 688403
🇷🇸Krusevac, Serbia
Chiesi Clinical Trial - Site 688404
🇷🇸Nis, Serbia
Chiesi Clinical Trial - Site 688405
🇷🇸Nis, Serbia
Institut za Plućne Bolesti Sremska Kamenica - Site 688464
🇷🇸Sremska Kamenica, Serbia
Institute for Pulmonary Diseases of Vojvodina - Site 688466
🇷🇸Sremska Kamenica, Serbia
Chiesi Clinical Trial - Site 688463
🇷🇸Uzice, Serbia
Chiesi Clinical Trial - Site 703401
🇸🇰Bardejov, Slovakia
Chiesi Clinical Trial - Site 703452
🇸🇰Humenné, Slovakia
Chiesi Clinical Trial - Site 703403
🇸🇰Košice, Slovakia
Chiesi Clinical Trial - Site 703453
🇸🇰Levice, Slovakia
Chiesi Clinical Trial - Site 703402
🇸🇰Spišská Nová Ves, Slovakia
Chiesi Clinical Trial - Site 710458
🇿🇦Benoni, South Africa
Chiesi Clinical Trial - Site 710451
🇿🇦Bloemfontein, South Africa
Chiesi Clinical Trial - Site 710456
🇿🇦Centurion, South Africa
Chiesi Clinical Trial - Site 710454
🇿🇦Durban, South Africa
Chiesi Clinical Trial - Site 710455
🇿🇦George, South Africa
Chiesi Clinical Trial - Site 710453
🇿🇦Johannesburg, South Africa
Chiesi Clinical Trial - Site 710452
🇿🇦Pretoria, South Africa
Chiesi Clinical Trial - Site 724454
🇪🇸Barakaldo, Spain
Chiesi Clinical Trial - Site 724403
🇪🇸Barcelona, Spain
Chiesi Clinical Trial - Site 724457
🇪🇸Barcelone, Spain
Chiesi Clinical Trial - Site 724401
🇪🇸Cordoba, Spain
Chiesi Clinical Trial - Site 724404
🇪🇸Madrid, Spain
Chiesi Clinical Trial - Site 724405
🇪🇸Madrid, Spain
Chiesi Clinical Trial - Site 724451
🇪🇸Madrid, Spain
Chiesi Clinical Trial - Site 724455
🇪🇸Palma De Mallorca, Spain
Chiesi Clinical Trial - Site 724458
🇪🇸Pontevedra, Spain
Chiesi Clinical Trial - Site 724452
🇪🇸Valencia, Spain
Chiesi Clinical Trial - Site 724402
🇪🇸Zaragoza, Spain
Chiesi Clinical Trial - Site 792412
🇹🇷Adana, Turkey
Chiesi Clinical Trial - Site 792410
🇹🇷Bornova, Turkey
Chiesi Clinical Trial - Site 792415
🇹🇷Canakkale, Turkey
Chiesi Clinical Trial - Site 792408
🇹🇷Istanbul, Turkey
Chiesi Clinical Trial - Site 792414
🇹🇷Kocaeli, Turkey
Chiesi Clinical Trial - Site 792413
🇹🇷Mersin, Turkey
Chiesi Clinical Trial - Site 792406
🇹🇷Pamukkale, Turkey
Chiesi Clinical Trial - Site 792411
🇹🇷Yenişehir, Turkey
Chiesi Clinical Trial - Site 792407
🇹🇷Zeytinburnu, Turkey
LLC "Euromedservice" - Site 804463
🇺🇦Chernivtsi, Ukraine
Chiesi Clinical Trial - Site 804452
🇺🇦Chernivtsi, Ukraine
Chiesi Clinical Trial - Site 804422
🇺🇦Dnepropetrovsk, Ukraine
Chiesi Clinical Trial - Site 804458
🇺🇦Dnipro, Ukraine
Ivano-Frankivsk City Clinical Hospital No. 1 - Site 804453
🇺🇦Ivano-Frankivs'k, Ukraine
The Ivano-Frankivsk National Medical Univeristy - Site 804465
🇺🇦Ivano-Frankivs'k, Ukraine
Chiesi Clinical Trial - Site 804402
🇺🇦Ivano-Frankivs'k, Ukraine
Chiesi Clinical Trial - Site 804453
🇺🇦Ivano-Frankivsk, Ukraine
Chiesi Clinical Trial - Site 804404
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804405
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804406
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804409
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804450
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804457
🇺🇦Kharkiv, Ukraine
Chiesi Clinical Trial - Site 804403
🇺🇦Kherson, Ukraine
Chiesi Clinical Trial - Site 804421
🇺🇦Kiev, Ukraine
Chiesi Clinical Trial - Site 804459
🇺🇦Kiev, Ukraine
Municipal Non-profit Enterpirse-Regional Territorial Medical - Site 804454
🇺🇦Kramatorsk, Ukraine
Chiesi Clinical Trial - Site 804420
🇺🇦Kremenchuk, Ukraine
Chiesi Clinical Trial - Site 804451
🇺🇦Kryvyi Rih, Ukraine
ARENSIA Exploratory Medicine Medical Center - Site 804468
🇺🇦Kyiv, Ukraine
Medical Center- OkClinic of International Institute of Clinical Studies, LLC - Site 804466
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804401
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804408
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804411
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804412
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804416
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804460
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804462
🇺🇦Kyiv, Ukraine
Chiesi Clinical Trial - Site 804427
🇺🇦Odessa, Ukraine
Limited Liability Company Medical and Diagnostic Center "Medion" - Site 804407
🇺🇦Poltava, Ukraine
Chiesi Clinical Trial - Site 804415
🇺🇦Vinnytsia, Ukraine
Chiesi Clinical Trial - Site 804417
🇺🇦Vinnytsia, Ukraine
Chiesi Clinical Trial - Site 804456
🇺🇦Vinnytsia, Ukraine
Chiesi Clinical Trial - Site 804455
🇺🇦Vinnytsya, Ukraine
Chiesi Clinical Trial - Site 804423
🇺🇦Zaporizhzhia, Ukraine
Chiesi Clinical Trial - Site 804426
🇺🇦Zaporozhye, Ukraine
Central City Hospital No.1 - Zhytomyr - Site 804467
🇺🇦Zhytomyr, Ukraine
Chiesi Clinical Trial - Site 826410
🇬🇧Belfast, United Kingdom
Chiesi Clinical Trial - Site 826409
🇬🇧Bradford, United Kingdom
Chiesi Clinical Trial - Site 826411
🇬🇧London, United Kingdom
Chiesi Clinical Trial - Site 826412
🇬🇧Rochdale, United Kingdom