Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- endothelial function before and after viagra treatment to patients with sickle cell anemia without pulmonary hypertension
研究概览
简要总结
The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with sickle cell anemia
排除标准
- •patients with sickle cell anemia during acute crisis
研究组 & 干预措施
viagra
viagra versus placebo will be given to patients with sickle cell anemia
干预措施: Viagra (Sildenafil) (Drug)
placebo
viagra versus placebo will be given to patients with sickle cell anemia
干预措施: placebo (Drug)
结局指标
主要结局
endothelial function before and after viagra treatment to patients with sickle cell anemia without pulmonary hypertension
时间窗: January 2009 till January 2011
次要结局
未报告次要终点