Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
Overview
- Phase
- Phase 4
- Intervention
- Viagra (Sildenafil)
- Conditions
- Sickle Cell Anemia
- Sponsor
- The Baruch Padeh Medical Center, Poriya
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- endothelial function before and after viagra treatment to patients with sickle cell anemia without pulmonary hypertension
- Status
- Withdrawn
- Last Updated
- 16 years ago
Overview
Brief Summary
The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients with sickle cell anemia
Exclusion Criteria
- •patients with sickle cell anemia during acute crisis
Arms & Interventions
viagra
viagra versus placebo will be given to patients with sickle cell anemia
Intervention: Viagra (Sildenafil)
placebo
viagra versus placebo will be given to patients with sickle cell anemia
Intervention: placebo
Outcomes
Primary Outcomes
endothelial function before and after viagra treatment to patients with sickle cell anemia without pulmonary hypertension
Time Frame: January 2009 till January 2011