Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil

Phase 4

Withdrawn

• Conditions: Sickle Cell Anemia
• Interventions: Drug: placebo; Drug: Viagra (Sildenafil)

• Registration Number: NCT00937144
• Lead Sponsor: The Baruch Padeh Medical Center, Poriya

Brief Summary

The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem cells colonies, and by measuring the effect of therapy on markers of inflammation (cell adhesion molecules and cytokines).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-09-24
• Status Verified: 2009-07
• Study First Submitted QC: 2009-07-09
• Study First Posted: 2009-07-10
• Study Start: 2009-09
• Primary Completion: 2009-09
• Study Completion: 2010-02
• Last Update Submitted: 2010-02-28
• Last Update Posted: 2010-03-02

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• patients with sickle cell anemia

Exclusion Criteria

• patients with sickle cell anemia during acute crisis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
placebo	placebo	viagra versus placebo will be given to patients with sickle cell anemia
viagra	Viagra (Sildenafil)	viagra versus placebo will be given to patients with sickle cell anemia

Primary Outcome Measures

Name	Time	Method
endothelial function before and after viagra treatment to patients with sickle cell anemia without pulmonary hypertension	January 2009 till January 2011

Trial Locations

Locations (1)

Baruch Padeh Poria Medical Center; 🇮🇱 Tiberias, Lower Galilee, Israel