Skin habituation after repeated suberythemal UV-exposure

Recruiting

• Conditions: non-melanoma skin cancer; Skin cancer; 10014982

• Registration Number: NL-OMON51636
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- Individuals between 18 and 35 years.
- Fitzpatrick skin types II, III, IV or VI
- Individuals free of any dermatological or systemic disorder which would
interfere with the results, at the discretion of the investigator.
- Individuals who have read, understood, and signed an informed consent
document relating to the specific study to which they are subscribing.

Exclusion Criteria

- Individuals taking medication which in the opinion of the investigator would
mask or interfere with the results.
- Individuals with chronic skin allergie
- Individuals with suntan or sunburn.
- Individuals with abnormal reactions to the sun.
- Individuals who use oral supplementation of vitamin D
- Subjects who used sun beds or were extensively exposed to UVR in the previous
30 days (e.g. during holidays), or are planning on doing so during the study
- Subjects who consumed alcohol 1 day prior to MED assessment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Minimal erythemal dose-levels (MED)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>changes in thickness of stratum corneum (SC) and epidermal thickness, SC levels<br /><br>of immunological markers and urocanic acid isomers, levels of 25(OH)D3 in serum</p><br>