Effect of Exercise on Muscle Proteome Signature
- Conditions
- Healthy
- Interventions
- Other: exercise training
- Registration Number
- NCT03270475
- Lead Sponsor
- Morten Hostrup, PhD
- Brief Summary
The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men
- Detailed Description
Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 8
- Healthy
- VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)
- Body mass index (BMI) of 19-26 kg/m2
- Normal ECG (electrocardiography)
- Serious adverse effects to exercise
- Chronic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Exercise exercise training 12-15 training sessions of 30 min over 4-5 weeks
- Primary Outcome Measures
Name Time Method Skeletal muscle proteome signature Change from baseline proteome signature at 5 weeks proteomics
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Nutrition, Exercise and Sports
🇩🇰Copenhagen, Denmark