The Effects of Exercise Intervention on Skeletal Muscle and Other Organs in Aged Population and the Discovery of Associated Circulating Biomarkers

Not Applicable

Recruiting

• Conditions: Age-related Functional Decline

• Registration Number: NCT06660706
• Lead Sponsor: National Yang Ming Chiao Tung University

Brief Summary

This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies. Utilizing interventional research and randomized trials combined with examining blood samples from elderly individuals engaged in exercise, we aim to investigate the effects of exercise on muscle health and explore the underlying mechanisms of muscle aging and related biomarkers. Interdisciplinary research allowed us to investigate the systemic impact of exercise on muscles. This approach allowed us to gain a better understanding of the interconnectedness of skeletal muscle and adipose tissue in the aging process and devise efficient strategies to reverse age-related changes. These findings hold promise for promoting a future society where long and healthy life is achievable for all.

Detailed Description

This study is a randomized controlled trial of 6-month multidomain intervention program among community-living older adults with early physical impairments.

Inclusion criteria are: (1) community-dwelling adults aged ≥ 65 years, (2) slow gait speed (\<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength \<28 kg in men, \<18 kg in women); subjects with the following conditions will be excluded: (1) established diagnosis of dementia, Parkinsonism or other neurodegenerative disease (2) disable status: mobilitylimiting conditions, (3) active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on, (4) estimated life expectancy \<12 months, (5) current nursing home residents.

Study Timeline

• Study Start: 2024-04-01
• Status Verified: 2024-10
• Study First Submitted: 2024-10-25
• Study First Submitted QC: 2024-10-25
• Last Update Submitted: 2024-10-25
• Study First Posted: 2024-10-28
• Last Update Posted: 2024-10-28
• Primary Completion: 2026-06
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• aged ≥ 65 years
• slow gait speed (<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength <28 kg in men, <18 kg in women)

Exclusion Criteria

• established diagnosis of dementia, Parkinsonism or other mobility-limiting, disable conditions
• active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on
• estimated life expectancy <12 months
• current nursing home residents

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in Physical performance	baseline, 6 month	Change in hand-grip strength (kg), or six-meter walking speed (m/s), or 5 times sit to stand test from baseline to 6 months in all participants

Secondary Outcome Measures

Name	Time	Method
Change in DHEA-S	baseline, 6 month	Change in DHEA-S concentration from baseline to 6 months in all participants
Change in IGF-1	baseline, 6 month	Change in IGF-1 concentration from baseline to 6 months in all participants
Change in hs-CRP	baseline, 6 month	Change in hs-CRP concentration from baseline to 6 months in all participants
Change in Myostatin	baseline, 6 month	Change in Myostatin concentration from baseline to 6 months in all participants
Change in Activing A	baseline, 6 month	Change in Activing A concentration from baseline to 6 months in all participants
Change in Follistatin	baseline, 6 month	Change in Follistatin concentration from baseline to 6 months in all participants
Change in Relative appendicular skeletal muscle index (RASM)	baseline, 6 month	Change in RASM from baseline to 6 months in all participants
Change in body fat %	baseline, 6 month	Change in body fat % from baseline to 6 months in all participants
Change in Cognitive performance	baseline, 6 month	Change in Montreal Cognitive Assessment (MoCA), or Mini-mental state examination (MMSE) from baseline to 6months in all participants
Change from lipoproflie	baseline, 6 month	Change in Total Cholesterol, Triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol from baseline to 6months in all participants

Trial Locations

Locations (1)

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University; 🇨🇳 Taipei, Taiwan