Non-Cirrhotic Hyperammonemia Versus Hyperlactatemia in Septic Patients and Impact of Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Serum ammonia specificity and sensitivity in predicting sepsis in comparison to lactate
研究概览
简要总结
Objectives: This study aims to determine the validity of hyperammonemia in predicting true sepsis compared to hyperlactemia in critically ill septic patients.
Background: Sepsis is associated with amino acid flux towards the liver, which increases the ammonia load. The combination of decreased clearance and increased load is thought to be the major cause of increased ammonia in sepsis.
Methodology: 60 septic patients were classified into 2 equal groups, Group I: Septic patients with positive microbial cultures. Group II: septic patients with negative cultures enrolled to obtain serum ammonia and lactic acid levels on admission and every six hours for three days. The primary outcome was to detect ammonia specificity and sensitivity in predicting sepsis in comparison to lactate. The secondary outcomes were need for mechanical ventilation, mortality, and length of stay (LHS) within the intensive care unit.
详细描述
Objectives: The study compares between non-cirrhotic hyperammonemia and hyperlactemia in predicting sepsis in critically ill septic patients.
The septic patients were classified into 2 equal groups, Group I: Septic patients with positive microbial cultures. Group II: septic patients with negative cultures enrolled to obtain serum ammonia and lactic acid levels on admission and every six hours for three days, to detect ammonia specificity and sensitivity in predicting sepsis in comparison to lactate. also, need for mechanical ventilation, mortality, and length of stay (LHS) within the intensive care unit were reported.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients aged 19-75 years old
- •both sexes with severe sepsis and septic shock
- •within the first 48 hours of ICU admission
排除标准
- •Hepatic patients (cirrhotic, hepatitis),
- •Renal failure, Ureterosigmoidostomy,
- •Malignancy or on Chemotherapy,
- •Pregnancy,
- •Parenteral nutrition,
- •Autoimmune diseases or Immunosuppressive illness, and
结局指标
主要结局
Serum ammonia specificity and sensitivity in predicting sepsis in comparison to lactate
时间窗: up to three days.
Blood samples to obtain Serial ammonia and lactic acid levels
次要结局
未报告次要终点
研究者
ashraf magdy eskandr
professor of anesthesia, ICU, Pain Management
Menoufia University