Haemodynamic stability during anaesthesia induction with propofol ? the impact of phenylephrine
Not Applicable
Completed
- Conditions
- Cardiovascular disease and abdominal cancer surgerySurgery
- Registration Number
- ISRCTN81365561
- Lead Sponsor
- Maribor University Clinical Centre (Slovenia)
- Brief Summary
2018 results in http://dx.doi.org/10.22514/SV141.052018.3 (added 29/05/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
ASA II-III patients scheduled for major abdominal surgery (large bowel resection, stomach resection, liver resection, Whipple resection) and major urologic surgery (bladder resection, prostatic cancer).
Exclusion Criteria
1. Alcohol-abuse
2. Drug abuse
3. Chronic use of benzodiazepines, opioids or other psychotropic substances
4. Body mass index > 30
5. Anticipated difficult intubation (Mallampati 3 and 4)
6. Kidney disease (serum creatinine > 120 mmol/l)
7. Manifest liver disease
8. Alzheimer disease
9. Epilepsy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Mean arterial pressure<br> 2. Cardiac output<br> 3. Systemic vascular resistance<br> All outcomes will be measured by the LIDCCORapid monitor for measuring cardiac output. The new generation of LIDCCORapid monitor enables also the measurement of the depth of anaesthesia with the BIS monitor. The measurements will be done at baseline and for 20 minutes during the induction of anaesthesia. The LIDCCORapid monitor enables automatic online collection of the data which will be averaged over one minute intervals for the period of induction. The averaged data for both groups of the results will be presented for baseline values, the values immediately before laryngoscopy and intubation, 2 minutes after intubation and then in 3 minute intervals till the end of measurements.<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Heart rate<br> 2. Stroke volume<br> 3. Bispectral index<br> 4. Oxygen saturation<br> 5. Dose of propofol<br> 6. Time from start of anaesthesia induction to laryngoscopy and intubation<br> 7. Dose of rescue drugs needed<br> The other secondary outcome measures: the dose of propofol during induction of anaesthesia, the time to laryngoscopy and intubation, the frequency of rescue medication used and the dose of rescue medication given is registered during the study for each study subject and the data are collected on our protocol sheet.<br>