Analysis of Passive Leg Raise Test on Blood Pressure in Critically Ill Patients.

Recruiting

• Conditions: Hypovolemia; Shock; Hemodynamic Instability

• Registration Number: NCT05554783
• Lead Sponsor: Medical University of Gdansk

Brief Summary

Positioning intensive care patients in Trendelenburg position to identify fluid responsiveness assessed by PiCCO device.

Detailed Description

It is a prospective observational study. Patients admitted to Intensive Care Unit of University Clinical Centre of Gdańsk, receiving advanced hemodynamic monitoring with PiCCO method will be enrolled. After blood pressure measurement, PiCCO will be calibrated with transpulmonary thermodilution with 10 - 20 ml of cold saline. Readings will be noted. The patient will be positioned in Trendelenburg position with it's head 15 degrees down. The increase of blood pressure after positioning in relation to the values obtained before the trial will be correlated to the parameters that asses patent's volaemia. After 5 minutes patient will be back to supine position and hemodynamic parameters will be recorded for another 5 minute.

Study Timeline

• Study Start: 2021-06-06
• Study First Submitted: 2022-04-21
• Status Verified: 2022-09
• Study First Submitted QC: 2022-09-23
• Last Update Submitted: 2022-09-23
• Study First Posted: 2022-09-26
• Last Update Posted: 2022-09-26
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• hemodynamic instability
• mechanical ventilation

Exclusion Criteria

• increased intracranial pressure
• increased intraabdominal pressure
• lower limbs sequential compression system
• agitation
• patients exposed to pain stimulus before the test
• aortic aneurysm
• left to right cardiac shunt
• severe valvular insufficiency

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of SVV with increase in blood pressure	10 minutes	Stroke volume variation (SVV) is a validated parameter that assess fluid responsiveness. In patients in whom SVV value is higher, theoretically Trendelenburg position will increase blood pressure in greater degree, than in patients in whom SVV is lower. We want to identify whether such correlation exist.

Trial Locations

Locations (1)

Medical University of Gdańsk - Department of Anesthesiology and Intensive Care; 🇵🇱 Gdańsk, Pomorskie, Poland