Comparison of the effects of fractionated dose injection versus conventional single dose injection of bupivacaine for sub-arachnoid block in patients undergoing caesarean sectio

Not Applicable

Conditions: Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Registration Number: CTRI/2019/12/022406

Lead Sponsor: CMS and GTB Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1.Full term pregnant patients (singleton) of the age group 18-35 years scheduled for lower segment caesarean section under spinal anaesthesia

2.Height in the range of 140cms- 170cms

3.ASA physical status grade I and II

4.Baseline systolic BP in the range of 110mmHg-130 mmHg

Exclusion Criteria

1.BMI of >= 30 kg/mÂ²

2.Pre-existing hypertension

3.Complicated pregnancy such as foetal distress, pregnancy induced hypertension, pre-eclampsia, eclampsia, cardiovascular, cerebrovascular disease, antepartum haemorrhage, hypovolemic shock, diabetes mellitus, etc.

4.Existing contraindication for spinal anaesthesia e.g. local infection, vertebral column deformity, etc.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total dose of mephentermine required to maintain the systolic blood pressure more than 100mmHg in the two groupsTimepoint: every 2 minutes initially for 30 minutes and every 5 minutes thereafter throughout the procedure.

Secondary Outcome Measures

Name	Time	Method
eonatal APGAR score in the two groupsTimepoint: at 1 minute and 5 minute of birth of the neonate;Number of episodes of bradycardia and the total dose of atropine required in the two groupsTimepoint: every 2 minutes initially for 30 minutes and every 5 minutes thereafter throughout the procedure.;Number of episodes of hypotension in the two groupsTimepoint: every 2 minutes initially for 30 minutes and every 5 minutes thereafter throughout the procedure.;Time required for complete onset of sensory and motor blockade in the two groupsTimepoint: every 2 minutes initially for 30 minutes and every 5 minutes thereafter throughout the procedure;Time taken for recovery of sensory and motor blockade in the two groupsTimepoint: every 15 minutes perioperatively till two segment regression from the highest blocked level