A Study of Guselkumab in Participants With Moderately to Severely Active Ulcerative Colitis
- Registration Number
- NCT04033445
- Lead Sponsor
- Janssen Research & Development, LLC
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of guselkumab in participants with moderately to severely active ulcerative colitis (UC).
- Detailed Description
UC is a chronic disease of the large intestine, in which the lining of the colon becomes inflamed and develops ulcers. Guselkumab is a fully human immunoglobulin G1 lambda monoclonal antibody (mAb) that binds to human interleukin (IL)-23 with high affinity. The study is designed to answer scientific questions pertaining to the efficacy and safety of guselkumab in the treatment of moderately to severely active UC. Overall, the study will evaluate long-term guselkumab treatment. Efficacy, safety, pharmacokinetics (PK), immunogenicity, and biomarkers will be assessed at specified time points.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1064
- Documented diagnosis of ulcerative colitis (UC)
- Moderately to severely active UC, defined by modified Mayo score
- Demonstrated inadequate response or intolerance to medical therapies specified in the protocol
- Screening laboratory test results within the parameters specified in the protocol
- Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, or Crohn's disease or clinical findings suggestive of Crohn's disease
- UC limited to the rectum only or to less than (<) 20 centimeter (cm) of the colon
- Presence of a stoma
- Presence or history of a fistula
- Receiving prohibited medications and/or treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Induction Study 1: Placebo IV Placebo Participants will receive matching placebo IV in Induction Study 1. Subsequent study treatment will be determined by the participant's clinical response status at Week 12. Clinical nonresponders will be administered guselkumab IV. Induction Study 2: Placebo IV Placebo Participants will receive matching placebo IV in Induction Study 2. Subsequent study treatment will be determined by the participant's clinical response status at Week 12. Clinical nonresponders will be administered guselkumab IV. Maintenance Study: Placebo SC Placebo Participants will receive matching placebo SC q4w. Induction Study 1: Guselkumab Dose 1 Guselkumab Participants will receive guselkumab dose 1 intravenously (IV) in Induction Study 1. Subsequent study treatment will be determined by the participant's clinical response status at Week 12. Induction Study 1: Guselkumab Dose 2 Guselkumab Participants will receive guselkumab dose 2 IV in Induction Study 1. Subsequent study treatment will be determined by the participant's clinical response status at Week 12. Induction Study 2: Guselkumab IV Guselkumab Participants will receive guselkumab IV in Induction Study 2. Subsequent study treatment will be determined by the participant's clinical response status at Week 12. Maintenance Study: Maintenance Dose Regimen 1 Guselkumab Participants will receive guselkumab maintenance dose regimen 1 subcutaneously (SC) every 4 weeks (q4w). Maintenance Study: Maintenance Dose Regimen 2 Guselkumab Participants will receive guselkumab maintenance dose regimen 2 SC every 8 weeks (q8w).
- Primary Outcome Measures
Name Time Method Induction Study 1: Percentage of Participants With Clinical Response at Week I-12 At Week I-12 Clinical response was defined as a decrease from induction baseline in the modified Mayo score by greater than or equal to (\>=) 30 percent (%) and \>=2 points, with either a \>=1 point decrease from baseline (Week 0 of IS-1) in the rectal bleeding subscore or a rectal bleeding subscore of 0 or 1. The modified Mayo scores consisted of 3 subscores: stool frequency, rectal bleeding and endoscopic subscore as determined during central review, each subscore graded from 0 (normal) to 3 (severe) with higher scores indicating more severe disease. These individual subscores were summed up to give a total modified Mayo score range of 0 (normal) to 9 (severe disease), where higher scores indicated more severe disease activity. This outcome measure was planned to be analyzed for specified arms only.
Induction Study 2: Percentage of Participants With Clinical Remission at Week I-12 At Week I-12 Clinical remission was based on the modified Mayo score. Clinical remission was defined as Mayo stool frequency subscore of 0 or 1 and not increased from baseline (Week 0 of IS-2), a Mayo rectal bleeding subscore of 0, and Mayo endoscopic subscore of 0 or 1 with no friability. The modified Mayo scores consisted of 3 subscores: stool frequency, rectal bleeding and endoscopic subscore as determined during central review, each subscore graded from 0 (normal) to 3 (severe) with higher scores indicating more severe disease. These individual subscores were summed up to give a total modified Mayo score range of 0 (normal) to 9 (severe disease), where higher scores indicated more severe disease activity. This outcome measure was planned to be analyzed for specified arms only.
Maintenance Study: Percentage of Participants With Clinical Remission at Week M-44 At Week M-44 Clinical remission was based on the modified Mayo score. Clinical remission was defined as Mayo stool frequency subscore of 0 or 1 and not increased from baseline (Week 0 of IS-1 and IS-2), a Mayo rectal bleeding subscore of 0, and Mayo endoscopic subscore of 0 or 1 with no friability. The modified Mayo scores consisted of 3 subscores: stool frequency, rectal bleeding and endoscopic subscore as determined during central review, each subscore graded from 0 (normal) to 3 (severe) with higher scores indicating more severe disease. These individual subscores were summed up to give a total modified Mayo score range of 0 (normal) to 9 (severe disease), where higher scores indicated more severe disease activity. This outcome measure was planned to be analyzed for randomized arms only.
- Secondary Outcome Measures
Name Time Method Induction Study 2: Percentage of Participants With Inflammatory Bowel Disease Questionnaire (IBDQ) Remission at Week I-12 At Week I-12 Induction Study 1: Percentage of Participants With Clinical Remission at Week I-12 At Week I-12 Induction Study 1: Percentage of Participants With Symptomatic Remission at Week I-12 At Week I-12 Induction Study 1: Percentage of Participants With Endoscopic Healing at Week I-12 At Week I-12 Induction Study 1: Percentage of Participants With Histologic-Endoscopic Mucosal Healing at Week I-12 At Week I-12 Induction Study 1: Percentage of Participants With Endoscopic Normalization at Week I-12 At Week I-12 Induction Study 2: Percentage of Participants With Symptomatic Remission at Week I-12 At Week I-12 Induction Study 2: Percentage of Participants With Endoscopic Healing at Week I-12 At Week I-12 Induction Study 2: Percentage of Participants With Clinical Response at Week I-12 At Week I-12 Induction Study 2: Percentage of Participants With Symptomatic Remission at Week I-4 At Week I-4 Induction Study 2: Percentage of Participants With Histologic-Endoscopic Mucosal Healing at Week I-12 At Week I-12 Induction Study 2: Percentage of Participants With Fatigue Response at Week I-12 At Week I-12 Induction Study 2: Percentage of Participants With Symptomatic Remission at Week I-2 At Week I-2 Induction Study 2: Percentage of Participants With Endoscopic Normalization at Week I-12 At Week I-12 Maintenance Study: Percentage of Participants With Symptomatic Remission at Week M-44 At Week M-44 Maintenance Study: Percentage of Participants With Endoscopic Healing at Week M-44 At Week M-44 Maintenance Study: Percentage of Participants With Corticosteroid-free Clinical Remission at Week M-44 At Week M-44 Maintenance Study: Percentage of Participants With Clinical Response at Week M-44 At Week M-44 Maintenance Study: Percentage of Participants With Histologic-Endoscopic Mucosal Healing at Week M-44 At Week M-44 Maintenance Study: Percentage of Participants With IBDQ Remission at Week M-44 At Week M-44 Maintenance Study: Percentage of Participants With Fatigue Response at Week M-44 At Week M-44 Maintenance Study: Percentage of Participants With Clinical Remission at Week 44 Among the Participants Who Had Achieved Clinical Remission at Maintenance Baseline At Week M-44 Maintenance Study: Percentage of Participants With Endoscopic Normalization at Week M-44 At Week M-44
Trial Locations
- Locations (384)
Om Research LLC
🇺🇸Lancaster, California, United States
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
Florida Research Network, LLC
🇺🇸Gainesville, Florida, United States
Harmony Medical Research Institute, Inc.
🇺🇸Hialeah, Florida, United States
I.H.S. Health. LLC
🇺🇸Kissimmee, Florida, United States
Vista Health Research, LLC
🇺🇸Miami, Florida, United States
Orlando Health
🇺🇸Orlando, Florida, United States
Atlanta Gastroenterology Associates
🇺🇸Atlanta, Georgia, United States
University of Chicago
🇺🇸Chicago, Illinois, United States
UCLA
🇺🇸Los Angeles, California, United States
Columbus Clinical Services LLC
🇺🇸Miami, Florida, United States
Care Access Research, Orlando
🇺🇸Orlando, Florida, United States
The Emory Clinic
🇺🇸Atlanta, Georgia, United States
Gastroenterolgy Associates of Central GA
🇺🇸Macon, Georgia, United States
University of Florida Health Jacksonville
🇺🇸Gainesville, Florida, United States
UF Health Jacksonville Gastroenterology Emerson
🇺🇸Jacksonville, Florida, United States
Synexus Clinical Research US Inc
🇺🇸Anderson, South Carolina, United States
Univ. of South Florida Med. Group
🇺🇸Tampa, Florida, United States
Morehouse School of Medicine
🇺🇸Atlanta, Georgia, United States
Atlanta Center For Gastroenterology
🇺🇸Decatur, Georgia, United States
Health Science Research Center
🇺🇸Pratt, Kansas, United States
Tri-State Gastroenterology Assoc
🇺🇸Crestview Hills, Kentucky, United States
Baystate Medical Center
🇺🇸Springfield, Massachusetts, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Clinton Township, Michigan, United States
Revive Research Institute
🇺🇸Farmington Hills, Michigan, United States
Duke University Hospital Medical Center
🇺🇸Raleigh, North Carolina, United States
Infusion Associates
🇺🇸Grand Rapids, Michigan, United States
Gastro Intestinal Research Institute of Northern Ohio LLC
🇺🇸Westlake, Ohio, United States
Erlanger Health System
🇺🇸Chattanooga, Tennessee, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Caprock Gastro Research
🇺🇸Lubbock, Texas, United States
Care Access Research- Salt Lake City
🇺🇸Salt Lake City, Utah, United States
Gastroenterology Associates of Tidewater
🇺🇸Chesapeake, Virginia, United States
CINME Centro de Investigaciones Metabolicas
🇦🇷Buenos Aires, Argentina
Clinica Adventista Belgrano
🇦🇷Ciudad De Buenos Aires, Argentina
Centro de Investigaciones Medicas Mar Del Plata
🇦🇷Mar Del Plata, Argentina
Monash Health
🇦🇺Clayton, Australia
Universitaetsklinikum Salzburg Landeskrankenhaus
🇦🇹Salzburg, Austria
AZ Sint-Lucas
🇧🇪Brugge, Belgium
Mid-America Gastro-Intestinal Consultants
🇺🇸Kansas City, Missouri, United States
Care Access Research, Poland
🇺🇸Youngstown, Ohio, United States
Digestive Disease Specialists Inc
🇺🇸Oklahoma City, Oklahoma, United States
US Digestive Health
🇺🇸Wyomissing, Pennsylvania, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Praxisgemeinschaft Jerichow
🇩🇪Jerichow, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH
🇩🇪Saarbrücken, Germany
Barnes-jewish Hospital
🇺🇸Saint Louis, Missouri, United States
Gastroenterology Associates of Orangeburg, SC
🇺🇸Orangeburg, South Carolina, United States
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Digestive Specialists, Inc
🇺🇸Springboro, Ohio, United States
Tyler Research Institute, LLC
🇺🇸Tyler, Texas, United States
Hospital de Alta Complejidad en Red 'El Cruce'
🇦🇷Florencio Varela, Argentina
Fiona Stanley Hospital
🇦🇺Murdoch, Australia
Mater Hospital
🇦🇺South Brisbane, Australia
Care Access Research, Ogden
🇺🇸Ogden, Utah, United States
Providence Medical Group
🇺🇸Spokane, Washington, United States
Care Access Research, Casper
🇺🇸Casper, Wyoming, United States
Centro Médico Dra. De Salvo
🇦🇷Caba, Argentina
Fundacion de Estudios Clinicos
🇦🇷Rosario, Argentina
Hospital Provincial del Centenario
🇦🇷Rosario, Argentina
Emeritus Research
🇦🇺Camberwell, Australia
Western Health
🇦🇺Footscray, Australia
St John of God Subiaco Hospital
🇦🇺Subiaco, Australia
Princess Alexandra Hospital
🇦🇺Woolloongabba, Australia
UW-Harborview Medical Center
🇺🇸Seattle, Washington, United States
Velocity Clinical Research Spokane
🇺🇸Spokane, Washington, United States
CEMIC (Centro de Educación Médica e Investigaciones Clínicas)
🇦🇷Buenos Aires, Argentina
Cer Instituto Medico
🇦🇷Buenos Aires, Argentina
Hospital General de Agudos José Maria Ramos Mejía
🇦🇷Buenos Aires, Argentina
Sanatorio Duarte Quiroz
🇦🇷Cordoba, Argentina
Royal Perth Hospital
🇦🇺Perth, Australia
Hopital Erasme
🇧🇪Brussels, Belgium
AZ Maria Middelares
🇧🇪Gent, Belgium
Universitair Ziekenhuis Gent
🇧🇪Gent, Belgium
Algemeen Ziekenhuis Jan Palfijn Merksem
🇧🇪Merksem, Belgium
Algemeen Ziekenhuis Delta
🇧🇪Roeselare, Belgium
L2IP Instituto de Pesquisas Clinicas
🇧🇷Brasilia, Brazil
Sociedade Campineira de Educacao e Instrucao Hospital e Maternidade Celso Pierro
🇧🇷Campinas, Brazil
CDC - Centro Digestivo de Curitiba
🇧🇷Curitiba, Brazil
Eurolatino Pesquisas Medicas Ltda
🇧🇷Uberlandia, Brazil
Instituto Mederi de Pesquisa e Saude
🇧🇷Passo Fundo, Brazil
Hospital das Clinicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul
🇧🇷Porto Alegre, Brazil
Universidade Federal do Rio de Janeiro - Faculdade de Medicina
🇧🇷Rio de Janeiro, Brazil
CLIAGEN - Clinica de Atencao em Gastroenterologia Especializada e Nutricao
🇧🇷Salvador, Brazil
BR Trials
🇧🇷Sao Paulo, Brazil
Onco Star SP Oncologia Ltda
🇧🇷Sao Paulo, Brazil
CPQuali Pesquisa Clinica LTDA ME
🇧🇷São Paulo, Brazil
CHU Saint-Pierre
🇧🇪Bruxelles, Belgium
Fundacao Universidade Federal do Piaui - Universidade Federal do Piaui
🇧🇷Teresina, Brazil
Medical Centre Asklepii OOD
🇧🇬Dupnitsa, Bulgaria
Medical Center-1-Sevlievo EOOD
🇧🇬Sevlievo, Bulgaria
2-nd MHAT
🇧🇬Sofia, Bulgaria
4th MHAT - Sofia
🇧🇬Sofia, Bulgaria
DCC Convex EOOD
🇧🇬Sofia, Bulgaria
Acibadem City Clinic - Oncology Center
🇧🇬Sofia, Bulgaria
MHAT 'St. Marina' EAD
🇧🇬Varna, Bulgaria
MHAT Dr Stefan Cherkezov
🇧🇬Veliko Tarnovo, Bulgaria
G I R I GI Research Institute Foundation
🇨🇦Vancouver, British Columbia, Canada
Health Sciences Centre
🇨🇦Winnipeg, Manitoba, Canada
Barrie GI Associates
🇨🇦Barrie, Ontario, Canada
Toronto Immune and Digestive Health Institute Inc
🇨🇦Toronto, Ontario, Canada
Hopital Maisonneuve Rosemont
🇨🇦Montreal, Quebec, Canada
Royal University Hospital
🇨🇦Saskatoon, Saskatchewan, Canada
Capital Medical University, Beijing Friendship Hospital
🇨🇳Beijing, China
Peking University Third Hospital
🇨🇳Beijing, China
China-Japan Union Hospital of Jilin University
🇨🇳Changchun, China
The second Xiangya Hospital of Central South University
🇨🇳Changsha, China
The Third Xiangya Hospital of Central Sourth University
🇨🇳Changsha, China
West China Hospital of Sichuan University
🇨🇳Chengdu, China
Daping Hospital
🇨🇳Chongqing, China
The Second Hospital To Dalian Medical University
🇨🇳Dalian, China
First Affiliated Hospital of Gannan Medical University
🇨🇳Ganzhou, China
The First Affiliated Hospital Sun Yat sen University
🇨🇳Guangzhou, China
The Sixth Affiliated Hospital Sun Yat sen University
🇨🇳Guangzhou, China
The First Affiliated Hospital Zhejiang University College of Medicine
🇨🇳Hangzhou, China
The Second Affiliated Hospital of Zhejiang University
🇨🇳Hangzhou, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, China
The First Affiliated Hospital of Anhui Medical University
🇨🇳Hefei, China
First Affiliated Hospital of Kunming Medical Unversity
🇨🇳Kunming City, China
The First Affiliated Hospital of NanChang University
🇨🇳Nanchang, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, China
Jiangsu Province Hospital
🇨🇳Nanjing, China
Ruijing Hospital Affiliated To Shanghai Jiaotong University School Of Medicine
🇨🇳Shanghai, China
Shengjing Hospital Of China Medical University
🇨🇳Shenyang, China
The Second Hospital Affiliated To Suzhou University
🇨🇳Suzhou, China
The first affiliated hospital of suzhou University
🇨🇳Suzhou, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, China
Wuhan Union Hospital
🇨🇳Wuhan, China
Tongji Hospital, Tongji Medical College of HUST
🇨🇳Wuhan, China
Wuxi People s Hospital
🇨🇳Wuxi, China
Nemocnice Ceske Budejovice a s
🇨🇿Ceske Budejovice, Czechia
Endohope Havirov s.r.o.
🇨🇿Havirov, Czechia
Gastroenterologie, s.r.o., Hradec Kralove
🇨🇿Hradec Kralova, Czechia
MUDr. Gregar s.r.o.
🇨🇿Olomouc, Czechia
Vitkovicka nemocnice a.s.
🇨🇿Ostrava, Czechia
Artroscan s r o
🇨🇿Ostrava, Czechia
AXON Clinical s.r.o.
🇨🇿Prague, Czechia
Synexus Czech s.r.o.
🇨🇿Praha 2, Czechia
ResTrial GastroEndo, s.r.o
🇨🇿Praha 4, Czechia
Nemocnice na Homolce
🇨🇿Praha 5, Czechia
ISCARE a.s.
🇨🇿Praha 9, Czechia
Nemocnice Strakonice, a.s.
🇨🇿Strakonice, Czechia
CHU caen
🇫🇷Caen, France
Hopital Beaujon
🇫🇷Clichy, France
CHRU de Lille Hopital Claude Huriez
🇫🇷Lille, France
Hopital Saint Eloi
🇫🇷Montpellier, France
CHU de Nice Hopital de l Archet
🇫🇷Nice Cedex 3, France
Hopital Saint Antoine
🇫🇷Paris, France
Hopital Haut-Leveque, CMC Magellan
🇫🇷Pessac, France
Centre Hospitalier Lyon Sud
🇫🇷Pierre-Benite, France
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
CHU Saint Etienne Hopital Nord
🇫🇷Saint-Priest en Jarez, France
Nouvel Hopital Civil
🇫🇷Strasbourg, France
CHU Rangueil
🇫🇷Toulouse, France
CHRU Nancy Brabois
🇫🇷Vandoeuvre les Nancy, France
Universitaetsklinikum Charite, Campus Virchow Klinikum
🇩🇪Berlin, Germany
BSF Studiengesellschaft
🇩🇪Halle, Germany
Staedtisches Klinikum Lueneburg
🇩🇪Lueneburg, Germany
Universitaetsklinikum Ulm
🇩🇪Ulm, Germany
Synexus Magyarorszag Kft
🇭🇺Gyula, Hungary
Magyar Honvedseg Egeszsegugyi Kozpont
🇭🇺Budapest, Hungary
Semmelweis University
🇭🇺Budapest, Hungary
Vasutegeszsegugyi Nonprofit Kozhasznu Kft
🇭🇺Debrecen, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Gyongyosi Bugat Pal Korhaz
🇭🇺Gyongyos, Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Orvostudomanyi Kar, Belgyogyaszati Klinika
🇭🇺Szeged, Hungary
St Vincent's University Hospital
🇮🇪Dublin 4, Ireland
Beaumont Hospital
🇮🇪Dublin, Ireland
University Hospital Galway - Ireland
🇮🇪Galway, Ireland
Rambam Medical Center
🇮🇱Haifa, Israel
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Wolfson Medical Center
🇮🇱Holon, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Lev Talpiot Clinic
🇮🇱Jerusalem, Israel
Galilee Medical Center
🇮🇱Naharia, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Policlinico Sant'Orsola Malpighi
🇮🇹Bologna, Italy
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Ospedale Classificato Equiparato Sacro Cuore Don Calabria di Negrar
🇮🇹Negrar, Italy
Azienda Ospedaliera di Padova
🇮🇹Padova, Italy
Ospedale Villa Sofia-Cervello
🇮🇹Palermo, Italy
Azienda Ospedaliera G.Salvini Ospedale di Rho
🇮🇹RHO, Italy
Università Campus Biomedico di Roma
🇮🇹Roma, Italy
Casa Sollievo Della Sofferenza IRCCS
🇮🇹San Giovanni Rotondo, Italy
Fondazione Policlinico Gemelli Università Cattolica
🇮🇹Roma, Italy
Istituto Clinico Humanitas Rozzano, IRCCS
🇮🇹Rozzano, Italy
AO Ordine Mauriziano
🇮🇹Torino, Italy
Institute of Science Tokyo Hospital
🇯🇵Bunkyo ku, Japan
Juntendo University Hospital Urayasu
🇯🇵Chiba, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Japan
Ehime Prefectural Central Hospital
🇯🇵Ehime, Japan
Sai Gastroenterology Proctology
🇯🇵Fujiidera-shi, Japan
Fukushima Medical University Hospital
🇯🇵Fukushima, Japan
Kitakyushu Municipal Medical Center
🇯🇵Fukuoka-ken, Japan
Fukuoka University Hospital
🇯🇵Fukuoka, Japan
Gifu University Hospital
🇯🇵Gifu, Japan
Hachinohe City Hospital
🇯🇵Hachinohe, Japan
Tokai University Hachioji Hospital
🇯🇵Hachioji, Japan
Hakodate Goryoukaku Hospital
🇯🇵Hakodate, Japan
Matsunami General Hospital
🇯🇵Hashima-gun, Japan
National Hospital Organization Hirosaki General Medical Center
🇯🇵Hirosaki, Japan
Hirosaki University Hospital
🇯🇵Hirosaki, Japan
Kure Kyosai Hospital
🇯🇵Hiroshima, Japan
Asahikawa Medical University Hospital
🇯🇵Hokkaido, Japan
Mito Saiseikai General Hospital
🇯🇵Ibaraki, Japan
Shimane University Hospital
🇯🇵Izumo, Japan
Kagoshima University Hospital
🇯🇵Kagoshima City, Japan
Imamura General Hospital
🇯🇵Kagoshima, Japan
Izuro Imamura Hospital
🇯🇵Kagoshima, Japan
Kagoshima IBD Gastroenterology Clinic
🇯🇵Kagoshima, Japan
Sameshima Hospital
🇯🇵Kagoshima, Japan
St Marianna University Hospital
🇯🇵Kanagawa, Japan
Matsushima Hospital
🇯🇵Kanagawa, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Japan
National Hospital Organization Kanazawa Medical Center
🇯🇵Kanazawa, Japan
Nara Medical University Hospital
🇯🇵Kashihara, Japan
The Jikei University Kashiwa Hospital
🇯🇵Kashiwa, Japan
Tsujinaka Hospital Kashiwanoha
🇯🇵Kashiwa, Japan
Kyushu Rosai Hospital
🇯🇵Kitakyushu, Japan
Kobe University Hospital
🇯🇵Kobe, Japan
Aoyama Naika Clinic
🇯🇵Kobe, Japan
National Hospital Organization Kochi National Hospital
🇯🇵Kochi, Japan
Yamanashi Prefectural Central Hospital
🇯🇵Kofu, Japan
Kumagaya General Hospital
🇯🇵Kumagaya-shi, Japan
National Hospital Organization Kure Medical Center and Chugoku Cancer Center
🇯🇵Kure, Japan
University Hospital Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
National Hospital Organization Matsumoto Medical Center
🇯🇵Matsumoto, Japan
National Hospital Organization Tokyo Medical Center
🇯🇵Meguro ku, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-ku, Japan
Kyorin University Hospital
🇯🇵Mitaka, Japan
Takagi Clinic
🇯🇵Miyagi, Japan
Iwate Medical University Uchimaru Medical Center
🇯🇵Morioka, Japan
Nagoya University Hospital
🇯🇵Nagoya, Japan
Nagoya City University Hospital
🇯🇵Nagoya, Japan
Nagaoka Chuo General Hospital
🇯🇵Niigata, Japan
Hyogo Medical University Hospital
🇯🇵Nishinomiya shi, Japan
Oita Red Cross Hospital
🇯🇵Oita, Japan
Shinbeppu Hospital
🇯🇵Oita, Japan
Nakagami Hospital
🇯🇵Okinawa, Japan
Kindai University Hospital
🇯🇵Osaka Sayama shi, Japan
Japanese Red Cross Osaka Hospital
🇯🇵Osaka, Japan
Osaka Metropolitan University Hospital
🇯🇵Osaka, Japan
Izumiotsu Municipal Hospital
🇯🇵Osaka, Japan
Osaki Citizen Hospital
🇯🇵Osaki, Japan
Japan Community Health Care Organization Saitama Medical Center
🇯🇵Saitama, Japan
Toho University Sakura Medical Center
🇯🇵Sakura, Japan
Sapporo Tokushukai Hospital
🇯🇵Sapporo, Japan
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
🇯🇵Sapporo, Japan
Sapporo Medical University Hospital
🇯🇵Sapporo, Japan
Sapporo IBD Clinic
🇯🇵Sapporo, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Japan
Tokyo Yamate Medical Center
🇯🇵Shinjuku-ku, Japan
Matsuda Hospital
🇯🇵Shizuoka, Japan
Tokyo Metropolitan Bokutoh Hospital
🇯🇵Sumida ku, Japan
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu, Japan
Tokushima University Hospital
🇯🇵Tokushima, Japan
The Jikei University Hospital
🇯🇵Tokyo, Japan
Mie University Hospital
🇯🇵Tsu, Japan
Yokkaichi Hazu Medical Center
🇯🇵Yokkaichi, Japan
Yokohama Municipal Citizen's Hospital
🇯🇵Yokohama, Japan
University of Fukui Hospital
🇯🇵Yoshida, Japan
Jordan University Hospital
🇯🇴Amman, Jordan
Istishari Hospital
🇯🇴Amman, Jordan
Khalidi Hospital and Medical Center
🇯🇴Amman, Jordan
Irbid Specialty Hospital
🇯🇴Irbid, Jordan
King Abdullah University Hospital
🇯🇴Irbid, Jordan
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
Korea University Ansan Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
The Catholic university of Korea, St. Vincent's Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
KyungHee University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St Mary s Hospital
🇰🇷Seoul, Korea, Republic of
Chung-Ang University Hospital
🇰🇷Seoul, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of
Pauls Stradins Clinical University Hospital
🇱🇻Riga, Latvia
Health Centre 4 Centre of Diagnostics
🇱🇻Riga, Latvia
Digestive Diseases Centre GASTRO
🇱🇻Riga, Latvia
Hospital Serdang
🇲🇾Kajang, Malaysia
Hospital University Sains Malaysia
🇲🇾Kelantan, Malaysia
Pusat Perubatan Universiti Kebangsaan Malaysia
🇲🇾Kuala Lumpur, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Onze Lieve Vrouwe Gasthuis
🇳🇱Amsterdam, Netherlands
Albert Schweitzer Ziekenhuis
🇳🇱Dordrecht, Netherlands
Radboudumc
🇳🇱Nijmegen, Netherlands
Dunedin Hospital
🇳🇿Dunedin, New Zealand
Auckland City Hospital
🇳🇿Grafton, New Zealand
Waikato Hospital
🇳🇿Hamilton, New Zealand
Gastromed Kralisz Romatowski Stachurska Sp. j.
🇵🇱Bialystok, Poland
Centrum Medyczne Medis ManerMed Sp Z O O
🇵🇱Bydgoszcz, Poland
Centrum Medyczne Plejady
🇵🇱Krakow, Poland
Centrum Medyczne Promed
🇵🇱Krakow, Poland
Gastromed ZOZ
🇵🇱Lublin, Poland
Medicome Sp z o.o.
🇵🇱Oswiecim, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
Endoskopia Sp z o.o.
🇵🇱Sopot, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
GASTROMED Sp. z o.o.
🇵🇱Torun, Poland
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji
🇵🇱Warszawa, Poland
Wojskowy Instytut Medyczny
🇵🇱Warszawa, Poland
Medical Network WIP Warsaw IBD Point Profesor Kierkus
🇵🇱Warszawa, Poland
Wro Medica
🇵🇱Wroclaw, Poland
Melita Medical Sp. z o.o.
🇵🇱Wroclaw, Poland
Pro Life Medica Sp z o o ETG Zamosc
🇵🇱Zamosc, Poland
Centro Hospitalar e Universitário de Coimbra, EPE
🇵🇹Coimbra, Portugal
Uls Santo Antonio - Hosp. Santo Antonio
🇵🇹Porto, Portugal
Uls Sao Joao - Hosp. Sao Joao
🇵🇹Porto, Portugal
Uls de Entre Douro E Vouga - Hosp. Sao Sebastiao
🇵🇹Santa Maria da Feira, Portugal
Centro Hospitalar de Tondela Viseu, EPE
🇵🇹Viseu, Portugal
Medical Center Meditsinskie Tekhnologii
🇷🇺Ekaterinburg, Russian Federation
OOO MO New Hospital
🇷🇺Ekaterinburg, Russian Federation
Immanuel Kant Baltic Federal University
🇷🇺Kaliningrad, Russian Federation
Road Clinical Hospital at the Nizhny Novgorod Station of the Russian Railways
🇷🇺Nizhniy Novgorod, Russian Federation
Medical Center SibNovoMed LLC
🇷🇺Novosibirsk, Russian Federation
LLC 'Novosibirsk Gastrocentr'
🇷🇺Novosibirsk, Russian Federation
City Clinical Hospital #2
🇷🇺Perm, Russian Federation
Rostov State Medical University
🇷🇺Rostov-On-Don, Russian Federation
All-Russian Center of Emergency and Radiation Medicine MCRS
🇷🇺Saint-Petersburg, Russian Federation
Eco-safety Ltd
🇷🇺Saint-Petersburg, Russian Federation
Medical University Reaviz
🇷🇺Samara, Russian Federation
NUZ 'Railway Clinical Hospital on Samara station of LLC 'Russian Railways'
🇷🇺Samara, Russian Federation
Saratov Regional Clinical Hospital
🇷🇺Saratov, Russian Federation
International Medical Centre SOGAZ
🇷🇺St-Petersburg, Russian Federation
GBUZ Respublican Clinical Hospital n.a. GG Kuvatova
🇷🇺Ufa, Russian Federation
City Clinical Hospital # 21
🇷🇺Ufa, Russian Federation
Regional Clinical Hospital
🇷🇺Yaroslavl, Russian Federation
Zvezdara University Medical Center
🇷🇸Belgrade, Serbia
General Hospital 'Dr Radivoj Simonovic'
🇷🇸Sombor, Serbia
General Hospital 'Djordje Joanovic'
🇷🇸Zrenjanin, Serbia
FNsP F.D.R. Banska Bystrica
🇸🇰Banska Bystrica, Slovakia
Gastroenterology Department GASTROMART s.r.o.
🇸🇰Bardejov, Slovakia
Gastroenterology Center ASSIDUO
🇸🇰Bratislava, Slovakia
Cliniq s.r.o.
🇸🇰Bratislava, Slovakia
ENDOMED s.r.o
🇸🇰Kosice, Slovakia
GASTRO I. s.r.o.
🇸🇰Presov, Slovakia
Accout Center, s.r.o., Gastroenterologická ambulancia
🇸🇰Sahy, Slovakia
Hosp. Univ. Germans Trias I Pujol
🇪🇸Badalona, Spain
Hosp Clinic de Barcelona
🇪🇸Barcelona, Spain
Hosp. Univ. Dr. Josep Trueta
🇪🇸Girona, Spain
Hosp. Univ. La Paz
🇪🇸Madrid, Spain
Hosp. Univ. Marques de Valdecilla
🇪🇸Santander, Spain
Hosp. Virgen Del Rocio
🇪🇸Sevilla, Spain
Hosp. Ntra. Sra. de Valme
🇪🇸Sevilla, Spain
Karolinska Universitetssjukhuset
🇸🇪Stockholm, Sweden
Uppsala University
🇸🇪Uppsala, Sweden
Chang-Hua Christian Hospital
🇨🇳Changhua, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Chang-Gung Memorial Hospital, LinKou Branch
🇨🇳Taoyuan, Taiwan
Hacettepe University Hospital
🇹🇷Ankara, Turkey
Gazi University Hospital
🇹🇷Ankara, Turkey
Trakya University Medical Faculty
🇹🇷Edirne, Turkey
Istanbul University Istanbul Medical Faculty
🇹🇷Istanbul, Turkey
Istanbul University Cerrahpasa Medical Faculty
🇹🇷Istanbul, Turkey
Medicana International Istanbul
🇹🇷Istanbul, Turkey
BAU Medical Park Goztepe Hospital
🇹🇷Istanbul, Turkey
Acibadem Kozyatagi Hospital
🇹🇷Istanbul, Turkey
Ege University Medical Faculty
🇹🇷Izmir, Turkey
Dokuz Eylul University Medical Faculty
🇹🇷Izmir, Turkey
Kocaeli University Medical Faculty
🇹🇷Kocaeli, Turkey
Mersin University Medical Faculty Hospital
🇹🇷Mersin, Turkey
Ivano-Frankivsk Regional Clinical Hospital
🇺🇦Ivano-Frankivsk, Ukraine
Communal Nonprofit Enterprise 'City Clinical Hospital # 2 N.A. Prof. O.O. Shalimov'
🇺🇦Kharkiv, Ukraine
SI 'L.T. Maloyi National Institute of Therapy of National Academy of Medical Sciences of Ukraine
🇺🇦Kharkiv, Ukraine
Municipal Institution 'Kherson City Clinical Hospital n.a. Y.Y.Karabelesh'
🇺🇦Kherson, Ukraine
Medical Center 'Ok Clinic' of LLC 'International Institute of Clinical Studies'
🇺🇦Kyiv, Ukraine
Limited Liability Company Progastro Clinic
🇺🇦Lviv, Ukraine
Kalyna Center of Modern Medicine
🇺🇦Lviv, Ukraine
Sumy State University, Sumy Regional Clinical Hospital
🇺🇦Sumy, Ukraine
MC PE Sygma
🇺🇦Kyiv, Ukraine
Municipal Non-profit Enterprise 'Odesa Regional Clinical Hospital' Odesa Regional Council
🇺🇦Odesa, Ukraine
Municipal institution of Tepnopil Regional Council 'Ternopil University Hospital'
🇺🇦Ternopil, Ukraine
Guy's and St Thomas' Hospital
🇬🇧London, United Kingdom
St George's Hospital
🇬🇧London, United Kingdom
Medical Center Ltd 'Health Clinic', Department Of General Therapy
🇺🇦Vinnytsya, Ukraine
Vinnitsia Regional Clinical Hospital n.a. M. I. Pyrogov
🇺🇦Vinnytsya, Ukraine
Glasgow Royal Infirmary
🇬🇧Glasgow, United Kingdom