A Study of Guselkumab in Participants With Active Psoriatic Arthritis
- Conditions
- Arthritis, Psoriatic
- Interventions
- Drug: Placebo
- Registration Number
- NCT04882098
- Lead Sponsor
- Janssen Research & Development, LLC
- Brief Summary
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1054
- Have active psoriatic arthritis (PsA) despite previous non-biologic disease-modifying antirheumatic drug (DMARD), apremilast, and/or nonsteroidal anti-inflammatory drug (NSAID) therapy
- Have a diagnosis of PsA for at least 6 months before the first administration of study agent and meet Classification criteria for Psoriatic Arthritis (CASPAR) at screening
- Have active PsA as defined by: at least 3 swollen joints and 3 tender joints at screening and at baseline; and C-reactive protein (CRP) greater than or equal to (>=) 0.3 milligrams per deciliter (mg/dL) at screening from the central laboratory
- Have >= 2 joints with erosions on baseline radiographs of the hands and feet as determined by central read
- Have at least one of the following PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with absence of rheumatoid nodules, arthritis mutilans, asymmetric peripheral arthritis, or spondylitis with peripheral arthritis
- Have active plaque psoriasis, with at least one psoriatic plaque of >= 2 centimeter (cm) diameter or nail changes consistent with psoriasis
- Has known allergies, hypersensitivity, or intolerance to study intervention or its excipients
- Has other inflammatory diseases that might confound the evaluations of benefit of guselkumab therapy, including but not limited to rheumatoid arthritis (RA), axial spondyloarthritis (AS)/non-radiographic axial spondyloarthritis (nr-axSpA), systemic lupus erythematosus, or Lyme disease
- Has previously received any biologic treatment
- Has ever received tofacitinib, baricitinib, filgotinib, peficitinib, decernotinib, upadacitinib or any other Janus kinase (JAK) inhibitor
- Has received any systemic immunosuppressants (example, azathioprine, cyclosporine, 6 thioguanine, mercaptopurine, mycophenolate mofetil, hydroxyurea, tacrolimus) within 4 weeks of the first administration of study intervention
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group 1: Guselkumab and Placebo Guselkumab Participants will receive guselkumab and placebo subcutaneously (SC) to maintain the blind. Participants who have not discontinued will be eligible to enter a long-term extension (LTE) and will receive guselkumab and placebo SC. After the study is unblinded to the investigative sites, participants will receive guselkumab and no longer be required to dose with placebo to maintain the blind. Group 1: Guselkumab and Placebo Placebo Participants will receive guselkumab and placebo subcutaneously (SC) to maintain the blind. Participants who have not discontinued will be eligible to enter a long-term extension (LTE) and will receive guselkumab and placebo SC. After the study is unblinded to the investigative sites, participants will receive guselkumab and no longer be required to dose with placebo to maintain the blind. Group 2: Guselkumab Guselkumab Participants will receive guselkumab SC. Participants who have not discontinued will be eligible to enter an LTE and will receive guselkumab SC. Group 3: Placebo Followed by Guselkumab Guselkumab Participants will receive placebo SC and will cross over to receive SC guselkumab. Participants who have not discontinued will be eligible to enter an LTE and will receive guselkumab SC. Group 3: Placebo Followed by Guselkumab Placebo Participants will receive placebo SC and will cross over to receive SC guselkumab. Participants who have not discontinued will be eligible to enter an LTE and will receive guselkumab SC.
- Primary Outcome Measures
Name Time Method Percentage of Participants Who Achieved an American College of Rheumatology (ACR) 20 Response at Week 24 Week 24 The ACR 20 Response is defined as greater than or equal to (\>=) 20 percent (%) improvement in swollen joint count (66 joints) and tender joint count (68 joints) and \>=20 percent improvement in 3 of following 5 assessments: participant's assessment of pain using Visual Analog Scale (VAS; 0-100 millimeter \[mm\], 0 mm=no pain and 100 mm=worst possible pain), participant's global assessment of disease activity by using VAS (scale ranges from 0 mm to 100 mm, \[0 mm= very well to 100 mm= very poor\]), physician's global assessment of disease activity using VAS (scale ranges from 0 to 100), \[0 = no arthritis to 100 = extremely active arthritis\], participant's assessment of physical function measured by Health Assessment Questionnaire-Disability Index (HAQ-DI, defined as a 20-question instrument assessing 8 functional areas. The derived HAQ-DI ranges from 0, indicating no difficulty, to 3, indicating inability to perform a task in that area) and C-reactive protein (CRP).
- Secondary Outcome Measures
Name Time Method Change From Baseline in Psoriatic Arthritis (PsA) Modified Van Der Heijde-Sharp (vdH-S) Total Score at Week 24 Baseline and Week 24 Modified vdH-S score is the sum of the erosion score (hand, feet) and joint space narrowing (JSN) score (hand, feet). Total score ranges from 0 (best) to 528 (worst = worst possible erosion score of 320 + worst possible JSN score of 208). Higher score indicates more joint damage. Positive changes from baseline in the modified vdH-S total, erosion and JSN scores indicate progression of joint damage.
Number of Participants with Adverse Events (AEs), Serious Adverse Events (SAEs), Reasonably Related AEs, as a Measure of Safety and Tolerability Up to 168 weeks Number of Participants with AEs, SAEs reasonably related AEs will be assessed. An AE is any untoward medical occurrence in a participant participating in a clinical study that does not necessarily have a causal relationship with the pharmaceutical/biological agent under study. SAE is any AE that results in: death, persistent or significant disability/incapacity, requires inpatient hospitalization or prolongation of existing hospitalization, is life-threatening experience, is a congenital anomaly/birth defect, and suspects transmission of any infectious agent via a medicinal product. Reasonably related AEs are those AEs which are judged related to study treatment by the investigator.
Number of Participants with AEs leading to Discontinuation of Study Intervention Up to 168 weeks Number of participants with AEs leading to discontinuation of study intervention will be reported.
Number of Participants with Infections Up to 168 weeks Number of participants with infections will be reported.
Number of Participants with AEs Temporally Associated With an Injection-site Reactions Up to 168 weeks Number of participants with AEs temporally associated with an injection-site reactions will be reported. An injection-site reaction is any adverse reaction at a subcutaneous (SC) study intervention injection-site. An AE is any untoward medical occurrence in a participant participating in a clinical study that does not necessarily have a causal relationship with the pharmaceutical/biological agent under study.
Number of Participants With Change from Baseline in Clinical Laboratory Abnormalities Baseline, up to 168 weeks Number of participants with change from baseline in clinical laboratory abnormalities including hematology and chemistry will be reported.
Number of Participants with Maximum Common Terminology Criteria for Adverse Events (CTCAE) toxicity grade Laboratory Values Up to 168 weeks Number of participants with maximum CTCAE toxicity grade laboratory values will be reported. Grade refers to the severity of the AE as follows: Grade 1- Mild, asymptomatic or mild symptoms, clinical or diagnostic observations only, intervention not indicated; Grade 2- Moderate, minimal, local or noninvasive intervention indicated, limiting age-appropriate instrumental Activities of Daily Living (ADL); Grade 3- Severe or medically significant but not immediately life-threatening, hospitalization or prolongation of hospitalization indicated, disabling, limiting self-care ADL; Grade 4- Life-threatening consequences, urgent intervention indicated; Grade 5- Death related to AE.
Serum Guselkumab Concentration Up to 168 weeks Serum guselkumab concentration will be measured.
Number of Participants with Anti-guselkumab Antibodies Up to 168 weeks Number of participants with anti-guselkumab antibodies to guselkumab will be reported.
Trial Locations
- Locations (269)
University Hospital Center Split
🇭🇷Split, Croatia
Klinicki bolnicki centar Zagreb
🇭🇷Zagreb, Croatia
Medicinski centar Kuna & Peric
🇭🇷Zagreb, Croatia
University Hospital Sveti Duh
🇭🇷Zagreb, Croatia
Revmacentrum MUDr Mostera s r o
🇨🇿Brno Zidenice, Czechia
Revmaclinic
🇨🇿Brno, Czechia
Revmatologie s r o
🇨🇿Brno, Czechia
L K N Arthrocentrum
🇨🇿Hlucin, Czechia
CCBR Ostrava s r o
🇨🇿Ostrava, Czechia
MUDr Rosypalova s r o
🇨🇿Ostrava, Czechia
CCBR Klinicka centra Czech, a.s.
🇨🇿Pardubice, Czechia
Fakultni nemocnice v Motole
🇨🇿Prague, Czechia
Revmatologicka ambulance
🇨🇿Praha 4, Czechia
Revmatologicky institut
🇨🇿Praha, Czechia
CCR Prague s.r.o.
🇨🇿Praha, Czechia
Medical Plus S R O
🇨🇿Uherske Hradiste, Czechia
PV Medical S R O
🇨🇿Zlin, Czechia
OU Innomedica
🇪🇪Tallinn, Estonia
North Estonia Medical Centre
🇪🇪Tallinn, Estonia
Sihtasutus Tartu Ulikooli Kliinikum - Nahahaiguste Kliinik
🇪🇪Tartu, Estonia
LTD Unimed Adjara
🇬🇪Batumi, Georgia
LTD Clinic LJ
🇬🇪Kutaisi, Georgia
Aleksandre Aladashvili Clinic LLC
🇬🇪Tbilisi, Georgia
Raymann Ltd
🇬🇪Tbilisi, Georgia
J S C K Eristavi National Cen
🇬🇪Tbilisi, Georgia
Tbilisi Heart and Vascular Clinic Ltd
🇬🇪Tbilisi, Georgia
LTD MediClub Georgia
🇬🇪Tbilisi, Georgia
Consilium Medulla-multiprofile clinic Ltd
🇬🇪Tbilisi, Georgia
Ltd Medicore
🇬🇪Tbilisi, Georgia
JSC Evex Hospitals
🇬🇪Tbilisi, Georgia
LTD The First Medical Center
🇬🇪Tbilisi, Georgia
Rheumatologische Schwerpunktpraxis
🇩🇪Berlin, Germany
Hamburger Rheuma Forschungszentrum II
🇩🇪Hamburg, Germany
Praxis fur Klinische Studien und Praxis fur Orthopadie
🇩🇪Hamburg, Germany
Rheumazentrum Ruhrgebiet
🇩🇪Herne, Germany
Institut Fur Praventive Medizin Klinische Forschung GbR
🇩🇪Magdeburg, Germany
Gemeinschaftspraxis Dres. Quist
🇩🇪Mainz, Germany
Rheumazentrum Ratingen
🇩🇪Ratingen, Germany
Naval Hospital of Athens
🇬🇷Athens, Greece
Hippokration Hospital
🇬🇷Athens, Greece
Laiko General Hospital of Athens
🇬🇷Athens, Greece
University Hospital Of Larissa, Biopolis
🇬🇷Larissa, Greece
Democritus University of Thrace
🇬🇷Xanthi, Greece
Revita Rendelo
🇭🇺Budapest, Hungary
Magyar Honvedseg Egeszsegugyi Kozpont
🇭🇺Budapest, Hungary
Uno Medical Trials Ltd.
🇭🇺Budapest, Hungary
Qualiclinic Kft
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hungary
Synexus Magyarorszag Kft
🇭🇺Zalaegerszeg, Hungary
MAV Korhaz es Rendelointezet
🇭🇺Szolnok, Hungary
Pest Megyei Flor Ferenc Korhaz
🇭🇺Kistarcsa, Hungary
A.O.U. Città della Salute e della Scienza
🇮🇹Torino, Italy
Soonchunhyang University Cheonan Hospital
🇰🇷Cheonan-si, Korea, Republic of
ClinicMed Badurski i Wspolnicy Spolka Jawna
🇵🇱Bialystok, Poland
Nasz Lekarz Przychodnie Medyczne
🇵🇱Torun, Poland
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Poland
Centrum Kliniczno Badawcze J Brzezicki B Gornikiewicz Brzezicka Lekarze Spolka Partnerska
🇵🇱Elblag, Poland
Ambulatorium Barbara Bazela
🇵🇱Elblag, Poland
Medica Pro Familia sp z o o S K A
🇵🇱Gdynia, Poland
Pratia MCM Krakow
🇵🇱Krakow, Poland
REUMED Zespol Poradni Specjalistycznych Filia nr 2
🇵🇱Lublin, Poland
NZOZ Lecznica Mak-Med sc
🇵🇱Nadarzyn, Poland
Twoja Przychodnia - Centrum Medyczne Nowa Sol
🇵🇱Nowa Sol, Poland
Prywatna Praktyka Lekarska Prof Um Dr Hab Med Pawel Hrycaj
🇵🇱Poznan, Poland
Medycyna Kliniczna
🇵🇱Warsaw, Poland
Rheuma Medicus Zaklad Opieki Zdrowotnej
🇵🇱Warszawa, Poland
Reumatika-Centrum Reumatologii, NZOZ
🇵🇱Warszawa, Poland
DERMMEDICA Sp.z o.o.
🇵🇱Wroclaw, Poland
Affidea Praha s r o
🇨🇿Praha, Czechia
St Ivan Rilski University Multiprofile Hospital For Active Treatment
🇧🇬Sofia, Bulgaria
DCC Convex EOOD
🇧🇬Sofia, Bulgaria
The First Bethune Hospital of Jilin University
🇨🇳Changchun, China
Changzhou No 2 Peoples Hospital
🇨🇳Changzhou, China
West China Hospital of Sichuan University
🇨🇳Chengdu, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, China
Linyi City People Hospital
🇨🇳Linyi, China
Pingxiang People's Hospital
🇨🇳Pingxiang, China
Huashan Hospital Fudan University
🇨🇳Shanghai, China
Shanghai skin disease hospital
🇨🇳Shanghai, China
Shengjing Hospital Of China Medical University
🇨🇳Shenyang, China
The hospital of Shanxi Universtidy
🇨🇳Taiyuan, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, China
Ch Osijek
🇭🇷Osijek, Croatia
KBC Rijeka
🇭🇷Rijeka, Croatia
Szegedi Tudományegyetem, ÁOK, Szent-Györgyi Albert Klinikai Központ
🇭🇺Szeged, Hungary
Csongrád Megyei Dr. Bugyi István Kórház
🇭🇺Szentes, Hungary
Barzilai Medical Center
🇮🇱Ashkelon, Israel
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Rambam Health Care Campus
🇮🇱Haifa, Israel
Meir Medical Center
🇮🇱Kfar Saba, Israel
Rabin Medical Center Beilinson Campus
🇮🇱Petah Tikva, Israel
The Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
PO G.Rodolico, AOU Policlinico-Vittorio Emanuele Catania
🇮🇹Catania, Italy
Ospedale San Raffaele, IRCCS
🇮🇹Milano, Italy
AOU Università degli Studi della Campania L. Vanvitelli
🇮🇹Napoli, Italy
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
🇮🇹Palermo, Italy
Università di Roma La Sapienza
🇮🇹Roma, Italy
Complesso Integrato Columbus
🇮🇹Rome, Italy
Reumex s.r.o
🇸🇰Rimavska Sobota, Slovakia
Splosna bolnisnica Izola
🇸🇮Izo, Slovenia
Bolnica Dr. Petra Drzaja
🇸🇮Ljubljana, Slovenia
UKC Maribor Dermatology clinic
🇸🇮Maribor, Slovenia
Hosp Univ A Coruna
🇪🇸A Coruna, Spain
Hosp Reina Sofia
🇪🇸Cordoba, Spain
Hosp. Univ. 12 de Octubre
🇪🇸Madrid, Spain
Hosp Regional Univ de Malaga
🇪🇸Malaga, Spain
Hosp. Univ. Virgen de La Arrixaca
🇪🇸Murcia, Spain
Hosp. Univ. de Mostoles
🇪🇸Móstoles, Spain
Hosp. Infanta Luisa
🇪🇸Sevilla, Spain
Akdeniz University Medical Faculty
🇹🇷Istanbul, Turkey
Izmir Katip Celebi University
🇹🇷Izmir, Turkey
Kocaeli University Medical Faculty
🇹🇷Kocaeli, Turkey
Selcuk University Medical Faculty
🇹🇷Konya, Turkey
Sumska oblasna klinichna likarnia
🇺🇦Sumy, Ukraine
Rheumatology Associates
🇺🇸Birmingham, Alabama, United States
STAT Research, Inc.
🇺🇸Springboro, Ohio, United States
Altoona Center For Clinical Research
🇺🇸Duncansville, Pennsylvania, United States
Dr. Ramesh Gupta
🇺🇸Memphis, Tennessee, United States
Austin Regional Clinic
🇺🇸Austin, Texas, United States
Adriana Pop Moody MD Clinic PA
🇺🇸Corpus Christi, Texas, United States
Southwest Rheumatology Research LLC
🇺🇸Mesquite, Texas, United States
Arthritis And Osteoporosis Clinic
🇺🇸Waco, Texas, United States
The Queen Elizabeth Hospital
🇦🇺Adelaide, Australia
Southern Clinical Research
🇦🇺Hobart, Australia
Emeritus Research
🇦🇺Melbourne, Australia
Eastern Health - Box Hill Hospital
🇦🇺Melbourne, Australia
Rheumatology Research Unit
🇦🇺Sunshine Coast, Australia
University Clinical center Republic of Srpska
🇧🇦Banja Luka, Bosnia and Herzegovina
Health center Gradiska
🇧🇦Gradiska, Bosnia and Herzegovina
Clinical hospital Mostar
🇧🇦Mostar, Bosnia and Herzegovina
Clinical Center University of Sarajevo
🇧🇦Sarajevo, Bosnia and Herzegovina
UMHAT Kaspela
🇧🇬Plovdiv, Bulgaria
MHAT Trimantium
🇧🇬Plovdiv, Bulgaria
Multiprofile Hospital for Active Treatment Plovdiv
🇧🇬Plovdiv, Bulgaria
Multiprofile Hosptal for Active Treatment Eurohospital Plovdiv
🇧🇬Plovdiv, Bulgaria
Medical Center Unimed Plovdiv
🇧🇬Plovdiv, Bulgaria
Medical Center Teodora
🇧🇬Ruse, Bulgaria
Medical Center Medconsult-Pleven
🇧🇬Sevlievo, Bulgaria
UMHAT Sv. Ivan Rilski
🇧🇬Sofia, Bulgaria
UMHAT St. Ivan Rilski
🇧🇬Sofia, Bulgaria
DCC XVII-Sofia EOOD
🇧🇬Sofia, Bulgaria
Medical Center Hera EOOD
🇧🇬Sofia, Bulgaria
Riga 1st Hospital
🇱🇻Riga, Latvia
J Kisis Ltd
🇱🇻Riga, Latvia
Orto Clinic Ltd
🇱🇻Riga, Latvia
Practice Dr Pociene Gilvina
🇱🇹Kaunas, Lithuania
Osteo-Medic s.c A. Racewicz, J Supronik
🇵🇱Bialystok, Poland
Arizona Arthritis and Rheumatology Research PLLC
🇺🇸Flagstaff, Arizona, United States
Arizona Arthritis & Rheumatology Associates PC
🇺🇸Glendale, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC
🇺🇸Tucson, Arizona, United States
Advanced Medical Research
🇺🇸La Palma, California, United States
Rheumatology Center of San Diego
🇺🇸San Diego, California, United States
Medvin Clinical Research, Inc.
🇺🇸Whittier, California, United States
Heuer M.D. Research
🇺🇸Orlando, Florida, United States
The Arthritis Center, Inc.
🇺🇸Palm Harbor, Florida, United States
Forcare Clinical Research Inc
🇺🇸Tampa, Florida, United States
Klein And Associates M D P A
🇺🇸Hagerstown, Maryland, United States
Advanced Rheumatology
🇺🇸Lansing, Michigan, United States
Arthritis Consultants
🇺🇸Saint Louis, Missouri, United States
Glacier View Research Institute
🇺🇸Kalispell, Montana, United States
NYU Langone Ambulatory Care Brooklyn Heights
🇺🇸Brooklyn, New York, United States
PMG Research of Salisbury
🇺🇸Salisbury, North Carolina, United States
Eastern Regional Health Authority St Clares Mercy Hospital
🇨🇦St Johns, Newfoundland and Labrador, Canada
Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Centre de Recherche Musculo Squelettique
🇨🇦Trois Rivieres, Quebec, Canada
Group De Recherche En Rhumatologie Et Maladies Osseuses
🇨🇦Quebec, Canada
Affiliated Hospital of Hebei University
🇨🇳Baoding, China
The First Affiliated Hospital of Baotou Medical University
🇨🇳Baotou, China
Peking University First Hospital
🇨🇳Beijing, China
Peking University Third Hospital
🇨🇳Beijing, China
Peking Union Medical College Hospital
🇨🇳Beijing, China
The Affiliated Hospital of Bengbu Medical College
🇨🇳Bengbu, China
The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, China
Guangzhou First Municipal People's Hospital
🇨🇳Guangzhou, China
the 3rd Affiliated Hospital,Sun Yansen University
🇨🇳Guangzhou, China
The Affiliated Hospital of Guizhou Medical University
🇨🇳Guiyang, China
The First Affiliated Hospital of NanChang University
🇨🇳Nanchang, China
The Second Affiliatde Hospital To Nanchang University
🇨🇳Nanchang, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Azienda Ospedaliera Universitaria Integrata Verona
🇮🇹Verona, Italy
Chonnam National University Hospital
🇰🇷Gwangju-si, Korea, Republic of
Hanyang University Hospital
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Seoul Metropolitan Government Seoul National University Boramae Medical Center
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of
M & M Centrs Ltd
🇱🇻Adazi, Latvia
P. Stradina Clinical University Hospital
🇱🇻Riga, Latvia
Riga East Clinical University Hospital
🇱🇻Riga, Latvia
Lietuvos sveikatos mokslų universiteto ligoninė Kauno klinik
🇱🇹Kaunas, Lithuania
Klaipeda University Hospital
🇱🇹Klaipeda, Lithuania
Siauliai Republican Hospital, Public Institution
🇱🇹Siauliai, Lithuania
JSC Inlita, Santaros KTC
🇱🇹Vilnius, Lithuania
Hospital Selayang
🇲🇾Batu Caves, Malaysia
Hospital Raja Permaisuri Bainun
🇲🇾Ipoh, Malaysia
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Hospital Melaka
🇲🇾Melaka, Malaysia
Sunway Medical Centre
🇲🇾Petaling Jaya, Malaysia
Hospital Tuanku Jaafar
🇲🇾Seremban, Malaysia
Angeles University Foundation Medical Center
🇵🇭Angeles, Philippines
Cebu Doctors' University Hospital
🇵🇭Cebu, Philippines
De La Salle University Medical Center
🇵🇭Dasmarinas, Philippines
Davao Doctors Hospital
🇵🇭Davao City, Philippines
Southern Philippines Medical Center
🇵🇭Davao, Philippines
University of Perpetual Help Dalta Medical Center, Inc
🇵🇭Las Pinas, Philippines
Manila Doctors Hospital
🇵🇭Manila, Philippines
Medical Center Manila
🇵🇭Manila, Philippines
Philippine General Hospital
🇵🇭Manila, Philippines
Chelyabinsk Regional Clinical Dermatovenerological Dispensary
🇷🇺Chelyabinsk, Russian Federation
LLC Aliance Biomedical-Ural group
🇷🇺Izhevsk, Russian Federation
State Budgetary Educational Institution of High Professional Education
🇷🇺Kazan, Russian Federation
Medical Center LLC Maxsimum Zdoroviya
🇷🇺Kemerovo, Russian Federation
LLC Family Outpatient Clinic # 4
🇷🇺Moscow, Russian Federation
GUZ of Moscow City Clinical Hospital # 1 n.a.N.I.Pirogov
🇷🇺Moscow, Russian Federation
GU Moscow Regional Research Clinical Institute n.a. M.F.Vla
🇷🇺Moscow, Russian Federation
FGBU Research Institute of Rheumatology named V.A.Nasonova
🇷🇺Moscow, Russian Federation
LLC Consultative and Diagnostic Center of Rheumatology Heal
🇷🇺Novosibirsk, Russian Federation
GBUZ Orenburg Clinical Regional Hospital
🇷🇺Orenburg, Russian Federation
Republican Hospital n.a.V.A.Baranov
🇷🇺Petrozavodsk, Russian Federation
Ryazan Regional Clinical Dermatovenerological Dispensary
🇷🇺Ryazan, Russian Federation
Ryazan Regional Clinical Cardiology Center
🇷🇺Ryazan, Russian Federation
Ryazan Regional Clinical Hospital
🇷🇺Ryazan, Russian Federation
LLC Sanavita
🇷🇺Sankt-Petersburg., Russian Federation
Sararov Regional Clinical Hospital
🇷🇺Saratov, Russian Federation
Federal North-West Medical Research Centre
🇷🇺St. Petersburg, Russian Federation
Northen-Western State Medical University n.a. I.I. Mechnikov
🇷🇺St.-Petersburg, Russian Federation
Ulyanovsk Regional Clinical Hospital
🇷🇺Ulyanovsk, Russian Federation
State Budget Healthcare Institution of Vladimir Region Regional Clinical Hospital
🇷🇺Vladimir, Russian Federation
Clinical Emergency Hospital n.a. N.V. Solovyev
🇷🇺Yaroslavl, Russian Federation
Clinical Hospital #3
🇷🇺Yaroslavl, Russian Federation
Institute of Rheumatology
🇷🇸Belgrade, Serbia
Military Medical Academy
🇷🇸Belgrade, Serbia
University Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
Institute for Treatment and Rehabilitation Niska Banja
🇷🇸Niska Banja, Serbia
Special Hospital for Rheumatic Diseases
🇷🇸Novi Sad, Serbia
Paediatric University Hospital
🇸🇰Kosice, Slovakia
Reumatologicka ambulancia
🇸🇰Martin, Slovakia
Chiremed, s.r.o.
🇸🇰Puchov, Slovakia
Complejo Hospitalario Universitario de Santiago. Servicio de Aparato Digestivo
🇪🇸Santiago de Compostela, Spain
Hosp. Nuestra Senora de La Esperanza
🇪🇸Santiago de Compostela, Spain
Hosp. Clinico Univ. de Santiago
🇪🇸Santiago de Compostela, Spain
Hosp. Virgen Macarena
🇪🇸Sevilla, Spain
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Kaohsiung Veterans General Hospital
🇨🇳Kaohsiung, Taiwan
Chang Gung Medical Foundation
🇨🇳Kaohsiung, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Linkou Chang Gung Memorial Hospital
🇨🇳Tao-Yuan, Taiwan
Chi Mei Medical Center Yong Kang
🇨🇳Yung-Kang, Taiwan
Communal Noncommercial Enterprise Cherkasy Regional Hospital of Cherkasy Regional Council
🇺🇦Cherkasy, Ukraine
Derzhavna ustanova Natsionalnyi instytut terapii imeni L.T.Maloi NAMN Ukrainy viddil klinichnoi
🇺🇦Kharkiv, Ukraine
Municipal Institution Regional hospital-center of emergency care and disasters medicine
🇺🇦Kharkiv, Ukraine
Khmelnitska oblasna likarnia
🇺🇦Khmelnitsky, Ukraine
TOV Revmocentr
🇺🇦Kiev, Ukraine
Komunalnyi zaklad Kryvorizka miska klinichna likarnia #2 Dnipropetrovskoi oblasnoi rady
🇺🇦Kryvyi Rih, Ukraine
Medical Research and Practice Center Medbud of the Public Joint Stock Holding Company Kyivmiskbud
🇺🇦Kyiv, Ukraine
State Institution Railway clinical Hospital 2
🇺🇦Kyiv, Ukraine
SI National Scientific Center Institute of Cardiology of M.D. Strazhesko of NAMS of Ukraine
🇺🇦Kyiv, Ukraine
Olexandrivska Clinical Hospital of Kyiv City
🇺🇦Kyiv, Ukraine
Kyivska oblasna klinichna likarnia
🇺🇦Kyiv, Ukraine
Center of Family Medicine Plus LLC
🇺🇦Kyiv, Ukraine
Kyiv Railway Station Clinical Hospital #2
🇺🇦Kyiv, Ukraine
Odeska oblasna klinichna likarnia
🇺🇦Odessa, Ukraine
Multidisciplinary Medical Center of Odessa National Medical University
🇺🇦Odessa, Ukraine
ME Poltava Regional Clinical Hospital named after M.V. Sklifosovsky of Poltava Regional Consuil
🇺🇦Poltava, Ukraine
Municipal Non-commercial Enterprise Ternopil University Hospital of Ternopil Regional Council
🇺🇦Ternopil, Ukraine
Naukovo-doslidnyi inst. Reabilit. Pyrogova [Revmatologichne]
🇺🇦Vinnytsia, Ukraine
Medical Center LTD Health Clinic Department of Cardiology and Rheumatology
🇺🇦Vinnytsya, Ukraine
Zhytomyr Central City Hospital #1
🇺🇦Zhytomyr, Ukraine