Sodium Bicarbonate for kidney protection in patients undergoing liver transplantatio

Phase 4

Completed

• Conditions: iver transplantation; Acute Kidney Injury; Liver transplantation; Anaesthesiology - Anaesthetics; Surgery - Other surgery; Renal and Urogenital - Other renal and urogenital disorders

• Registration Number: ACTRN12611001290987
• Lead Sponsor: Austin Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-12-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Adult patients undergoing orthotopic liver transplantation

Exclusion Criteria

1. End stage renal disease (plasma creatinine >300 mmol/L)
2. Preoperative renal replacement therapy
3. Intraoperative continuous veno-veno haemofiltration
4. Combined liver-kidney transplant
5. Fulminant hepatic failure
6. Congestive cardiac failure
7. Preoperative hypernatraemia (serum sodium > 150 mmol/L)
8. Preoperative hyponatraemia (serum sodium < 130 mmol/L) concerns with central pontine myelinosis from additional Sodium load from study solution.
9. Preoperative hypokalaemia (serum potassium < 3.0 mmol/L)
10. Informed consent not obtained
11. Pregnancy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum creatinine[Immediately postoperatively, then 24 hours and 72 hours postoperatively];Glomerular Filtration Rate (GFR)[Immediately postoperatively, then 24 hours and 72 hours postoperatively]