Sodium Bicarbonate for the prevention of contrast induced nephropathy in patients suspected with acute pulmonary embolism undergoing CTPA
Phase 3
Completed
- Conditions
- acute renale failure following contrastcontrastnephropathy1006447710029149
- Registration Number
- NL-OMON38375
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 140
Inclusion Criteria
eGFR < 60 ml/min
Exclusion Criteria
* age < 18 years
* exposure to radiographic contrast media within 7 days
* pregnancy
* systolic bloodpressure < 100 mmHg
* allergy for iso osmolar contrast agents
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* mean increase in serumcreatinine 2-4 days after CT-PA.</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Increase in serum creatinine > 25% or > 44 µmol/l 4 days (+ / - 1 day) after<br /><br>CTPA with contrast media.<br /><br>* Increase in serum creatinine > 25% or > 44 µmol/l 2 months after CTPA with<br /><br>contrast media or the need for dialysis.<br /><br>* Increase in C-cystatine and NGAL 3 days (+/- 1 day) after CT-PA.<br /><br>* Increase in NGAL 2 hours after CT-PA.</p><br>