IRCT20140120016280N4已完成3 期
Evaluation of Memantine’s Effect on Symptom Characteristics, Neuro-Cognitive Functioning and Neuronal Networks Organization in Patients with Obsessive-Compulsive Disorder: A Randomized, Double-blind, Placebo-Controlled Clinical Trial with Parallel Design
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 48
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 50 years（—）
- 性别
- All
入选标准
- •Definitive diagnosis of obsessive-compulsive disorder based on the psychiatrist assessment and its confirmation according to SCID-5 (Structured-Clinical Interview for DSM5) by the clinical psychologist
- •Y-BOCS Score equal or more than 16 for obsessions and compulsions or equal or more than 10 only for obsessions or compulsions.
- •Being in The age range of 18-50
- •IQ level more than 80 based on Wechsler Adult Intelligence Scale
- •Signing written informed consent
排除标准
- •Subjects with major depressive disorder, bipolar disorder, personality disorder, and schizophrenia in a way that questions the diagnose of obsessive-compulsive disorder.
- •Pregnancy, lactation or the imminent possibility of either of these cases or use of birth control methods for female subjects (these items will be assessed by the validated urine tests)
- •Past or current drug/alcohol abuse or dependence (these items will be assessed by the urine toxicology tests)
- •Previous exposure to any kind of psychotropic medication (benzodiazepines, antipsychotics, antidepressants, stimulants, mood stabilizers)
- •Previous exposure to at least 8 sessions of structured psycho-therapeutic courses
- •Past history or current existence of neurological diseases (seizures, epilepsy syndromes, history of trauma, stroke, loss of consciousness) and other severe internal and surgical disorders
- •Presence of any contraindication to MRI scanning, including metal implants or claustrophobia. Metal implants, pacemaker, other metal (e.g. shrapnel or surgical prostheses) or paramagnetic objects contained within the body which may present a risk to the subject or interfere with the MR scan, as determined in consultation with a neuroradiologist and according to the guidelines set forth in the following reference book commonly used by the neuroradiologists:Guide to MR procedures and metallic objects, F. G.
- •Increase in liver enzymes SGOT and SGPT more than threefold compared with baseline levels.
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