Non-invasive BCI for Cognitive Enhancement

Not Applicable

Completed

• Conditions: Healthy Subjects; Neuropsychiatric Disorders
• Interventions: Device: Behavior based perceptual training; Device: EEG-based perceptual training

• Registration Number: NCT05311878
• Lead Sponsor: University of Texas at Austin

Brief Summary

People's perceptual skills can significantly affect their abilities to make optimal decisions, judgments, and actions in real-world dynamic environments. Perceptual learning refers to training and experiences to induce improvements in the ability to make sense of what people see, hear, feel, taste or smell based on ambiguous sensory information. In this study, investigators hypothesise that there exist neural signatures that robustly encode the conscious visual perception of rotations of a cursor and the magnitudes of these rotations in a novel, rotation-based perceptual learning task. Investigators also hypothesise that online, instantaneous EEG-based feedback on subjects' visual perceptions of rotations with an EEG-based Brain Computer Interface (BCI) can foster perceptual learning much more effectively than behaviour perceptual training, especially in very small rotation magnitudes that represent extremely difficult perceptual tasks.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-01
• Study First Submitted: 2022-02-22
• Study First Submitted QC: 2022-03-25
• Study First Posted: 2022-04-05
• Primary Completion: 2023-11-01
• Study Completion: 2023-11-01
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-21
• Last Update Posted: 2025-04-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Able-bodied volunteers:

• good general health
• normal or corrected vision
• no history of neurological/psychiatric disease
• ability to read and understand English
• ability to understand information and ability to give a free and informed consent

Subjects with neuropsychiatric diseases

• Subjects with neuropsychiatric diseases such as bipolar disorder and schizophrenia.
• normal or corrected vision
• ability to read and understand English
• ability to understand information and ability to give a free and informed consent

Exclusion Criteria

• short attentional spans or cognitive deficits that prevent to remain concentrated during the experimental sessions
• concomitant serious illnesses (e.g., metabolic disorders, cardiac arrest)
• factors hindering proper EEG acquisition (e.g., scalp wound, uncontrolled muscle activity)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Behavior based perceptual training	Behavior based perceptual training	Subjects complete a perceptual learning task in which ground truth visual feedback is provided
EEG based perceptual training	EEG-based perceptual training	Subjects complete a perceptual learning task in which EEG-based visual feedback is provided

Primary Outcome Measures

Name	Time	Method
Change in correct answer rate of different rotation magnitudes across 5 intervention sessions	Difference is measured every 24 hours, before versus after each intervention session	The correct answer rate per rotation magnitude reflects the improvements in perceptual skills across the two conditions. It measures the percentage of each rotation magnitude spotted correctly. The score is 0-100, and the higher the value, the better the outcome.

Secondary Outcome Measures

Name	Time	Method
Change in neural correlates of conscious perception across 5 intervention sessions	Difference is measured every 24 hours, before versus after each intervention session	This outcome measures whether neural correlates of conscious perception (e.g. amplitude, peak-to-peak, band power and connectivity measures of neural correlates) change across sessions as a result of intervention.

Trial Locations

Locations (1)

Engineering Education and Research Center; 🇺🇸 Austin, Texas, United States