Computer-Based Therapy for Mild Cognitive Impairment
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Mild Cognitive Impairment
- Sponsor
- Posit Science Corporation
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- The study investigates changes in a neuropsychological assessment battery pre-randomization
- Status
- Completed
- Last Updated
- 20 years ago
Overview
Brief Summary
The purpose of this study is to determine the neuropsychological and neurophysiological impacts of a computer-based training program designed to improve the cognitive performance of patients with mild cognitive impairment (MCI).
Detailed Description
The study is a randomized, double-blind, controlled trial of a computerized, cognitive intervention with three main goals: 1) to assess the magnitude of improvements in memory, language function, and cognitive function following computer training, 2) to investigate the neurophysiological mechanisms underlying such neuropsychological improvements, and 3) to demonstrate the feasibility of using this kind of computer-based therapy in older populations.
Investigators
Eligibility Criteria
Inclusion Criteria
- •65 - 90 years of age 2)Meet definition for MCI including complaints of cognitive decline as indicated by patient report and/or informant report, and corroborated by clinician judgment and, the absence of dementia, defined as impairment of memory and at least one other domain of cognitive function.
- •Fluency in English 4)Willing to meet the time commitment of the study
Exclusion Criteria
- •Clinically significant cerebrovascular disease
- •Individuals scheduled to begin acetylcholinesterase inhibitor (AChEI) therapy -
Outcomes
Primary Outcomes
The study investigates changes in a neuropsychological assessment battery pre-randomization
and upon the completion of training.
Secondary Outcomes
- Early evaluations will be conducted from brain imaging; specifically, date
- obtained via positron emission tomography (PET), magnetoencephalography (MEG),
- electroencephalography (EEG), and functional magnetic resonance imaging (fMRI)
- studies.