Ordered Eating and Acute Exercise

Not Applicable

Recruiting

• Conditions: Glucose Metabolism Disorders; Hunger
• Interventions: Other: Carbohydrate-first meal; Other: Carbohydrate-last meal

• Registration Number: NCT06242015
• Lead Sponsor: Old Dominion University

Brief Summary

There is well documented evidence that ingesting dietary carbohydrate in large amounts tends to increase postprandial glucose. In healthy populations, this is not necessarily a problem, but continuous exposure to high levels of glucose-hyperglycemia-is a defining characteristic and risk factor for type 2 diabetes mellitus. Consuming a carbohydrate-rich food as the final food in a meal sequence has been shown to significantly reduce postprandial glucose excursions in both diabetes patients and in healthy controls. The exact mechanisms behind this phenomenon are not well understood, but one proposed course is simply that the vegetable and protein already being digested slows the rate of glucose rise.

Despite the findings, little-to-no research has examined how manipulating the order of foods in a meal impacts subsequent exercise responses. In this experimental crossover study, each participant will undergo two acute feeding conditions (carbohydrate-rich foods first vs. last in a meal), which will be followed by exercise 60 minutes later. We will observe the effects of meal order on postprandial glucose, substrate/fuel utilization, and subjective perceptions at rest and during 30 minutes of exercise.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-01-28
• Study First Submitted QC: 2024-01-28
• Study First Posted: 2024-02-05
• Study Start: 2024-02-06
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-01
• Last Update Posted: 2024-04-03
• Primary Completion: 2025-07-30
• Study Completion: 2025-07-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Currently physically active (scheduled exercise at least three days per week for 30 minutes each time over the last three months)
• Ability to perform moderate-to-high intensity running for at least 30 minutes

Exclusion Criteria

• Any allergy or other condition that would prohibit the consumption of poultry, rice, or broccoli
• Any injury or disease (cardiovascular disease, diabetes, pulmonary disease except controlled asthma) precluding physical exercise
• Currently pregnant
• Implanted electrical devices such as a pacemaker.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Carbohydrate-first meal	Carbohydrate-first meal	-
Carbohydrate-last meal	Carbohydrate-last meal	-

Primary Outcome Measures

Name	Time	Method
Postprandial glucose	2 hours (premeal and 30, 60, 90, and 120 minutes after eating)	Blood glucose will be measured with fingerstick samples and a portable glucometer

Secondary Outcome Measures

Name	Time	Method
Hunger-satiety perceptions	2 hours (Premeal and at 15, 30, 45, 60, 68, 78, 88, 120 minutes after eating)	Hunger, appetite, satiety, and fullness on a 0-10 Likert scale
Carbohydrate use	100 minutes (premeal and continuously for 90 minutes after eating)	Carbohydrate utilization will be estimated from respiratory gas exchange
Fat use	100 minutes (premeal and continuously for 90 minutes after eating)	fat utilization will be estimated from respiratory gas exchange
Rating of perceived exertion	30 minutes (at 8, 18, 28 minutes of exercise)	Rating of effort during 30-minute exercise bout

Trial Locations

Locations (1)

ODU Human Performance Laboratory; 🇺🇸 Norfolk, Virginia, United States