Intrinsic PEEP During Mechanical Ventilation of Patients With Obesity

Not Applicable

Completed

• Conditions: Laparoscopic Cholecystectomy; General Anesthesia
• Interventions: Device: RR 16 + 5; Device: RR 10 + 0; Device: RR 10 + 5; Device: RR 16 + 0; Device: RR 6 + 5; Device: RR 6 + 0

• Registration Number: NCT01267916
• Lead Sponsor: Seoul Medical Center

Brief Summary

It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEP) is present in grossly obese subjects especially in the supine position. The investigators tried to investigate the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.

Detailed Description

Impaired gas exchange is a common anesthetic problem in obese subjects. It is demonstrated that expiratory flow limitation and as a consequence, intrinsic positive end-expiratory pressure (PEEPi) is present in grossly obese subjects especially in the supine position. It is known that there is a significant negative correlation between PEEPi present and PaO2. Therefore, the investigators postulated that if the reduce the PEEPi by reducing the respiratory rate in obese subjects, the impaired gas exchange might improve.

The investigators tried to research the effect of low respiratory rate and high tidal volume on the intrinsic PEEP and gas exchange for obese subjects undergoing general anesthesia.

Study Timeline

• Study First Submitted: 2010-12-28
• Study First Submitted QC: 2010-12-28
• Study First Posted: 2010-12-29
• Study Start: 2011-01
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Status Verified: 2012-01
• Last Update Submitted: 2012-01-29
• Last Update Posted: 2012-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• ASA class I or II obesity, Body-mass index > 27.5 undergoing laparoscopic cholecystectomy

Exclusion Criteria

• patients with severe cardiopulmonary disease peak inspiratory pressure > 40 in the study setting

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RR 16 + 5	RR 16 + 5	Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 5
RR 10 + 0	RR 10 + 0	Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 0
RR 10 + 5	RR 10 + 5	Respiratory rate 10 Tidal volume 10 ml/kg external PEEP = 5
RR 16 + 0	RR 16 + 0	Respiratory rate 16 Tidal volume 6.25 ml/kg external PEEP = 0
RR 6 + 5	RR 6 + 5	Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 5
RR 6 + 0	RR 6 + 0	Respiratory rate 6 Tidal volume 16.7 ml/kg external PEEP = 0

Primary Outcome Measures

Name	Time	Method
Gas change parameters	15 minute interval	PaO2 and PaCO2 the result of arterial blood gas analysis

Secondary Outcome Measures

Name	Time	Method
intrinsic positive end-expiratory pressure	every 15 minutes	PEEPi measured by expiratory port occlusion method

Trial Locations

Locations (1)

Seoul Medical Center; 🇰🇷 Seoul, Korea, Republic of