The effects of acute and long-term apple consumption on risk factors for cardiovascular disease

Not Applicable

Completed

• Conditions: Cardiovascular Disease; Gut Microbiome; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Cardiovascular - Hypertension; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12615000361505
• Lead Sponsor: The University of Western Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-21
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

We are looking for volunteers with one or more of the following:
-Slightly elevated blood pressure (120 < systolic BP < 160)
-High blood sugar (5.6 < glucose < 6.5)
-High cholesterol (5 < total cholesterol < 8)
-Central obesity (men > 94cm; women > 80cm)
It is critical to the study that participants are not currently taking any blood pressure or cholesterol lowering medication.

Exclusion Criteria

- Current or recent (12 months) smoking
- Body mass index less than 18 or greater than 40 kg/m2
- History of cardiovascular or peripheral vascular disease
- A systolic blood pressure less than 100 or greater than 160 mmHg.
- A diastolic blood pressure less than 50 or greater than 100 mmHg
- Diagnosed diabetes, and non-diabetic individuals with fasting plasma glucose concentrations greater than 6.5 mmol/L
- A psychiatric illness
- Other major illnesses such as cancer
- Current or recent (within previous 6 months) significant weight loss or gain ( greater than 6% of body weight) or actively trying to lose weight
- Alcohol intake greater than 210g per week for women and greater than 280 g per week for men
- Women who are lactating, pregnant or wishing to become pregnant during the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome: % Flow-mediated dilatation of the brachial artery assesed by ultrasonogaphy. [Timepoint for chronic intervention: Baseline and 4 weeks after intervention commencement <br>Timepoint for acute intervention: Baseline and 2 hours after intervention]