NCT05408728Enrolling By Invitation不适用
Dietary Sugar Hyper-absorptive Intestinal Phenotype as a Predictor of Weight Loss Post-bariatric Surgery
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- Mayo Clinic
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Number of obese patients with altered dietary sugar hyper-absorptive phenotype after bariatric surgery
研究概览
简要总结
This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the dietary sugar absorptive characteristics.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Obese patients (BMI ≥ 30) scheduled for BS undergoing standard of care screening EGD, or lean BS-naïve individuals (BMI ≤ 25) subjected to EGD for routine clinical indications as part of standard care.
排除标准
- •Adults unable to consent, including non-English speakers.
- •Pregnant women because endoscopy is a risk factor. All patients of childbearing age undergo history as well as urine pregnancy test as a standard of care prior to undergoing endoscopy as the procedure is performed under anesthesia.
- •Prisoners.
- •Subjects with preexisting conditions (e.g., bleeding at the time of the procedure, suspected perforation during the standard-of-care procedure) will be excluded from the study at the time of the endoscopy.
- •Have a contraindication to endoscopy.
- •A history of surgery on the stomach or small intestine.
- •Type 1 diabetes (clinical diagnosis and/or positive glutamic acid decarboxylase antibodies).
- •Using weight loss medications.
- •Active malignancy within the last 5 years.
结局指标
主要结局
Number of obese patients with altered dietary sugar hyper-absorptive phenotype after bariatric surgery
时间窗: 18 months
次要结局
- Epigenetic changes measured in the intestinal mucosa of obese patients with dietary sugar hyper-absorptive phenotype after bariatric surgery(18 months)
研究者
Dilhana S. Badurdeen
Principal Investigator
Mayo Clinic
研究点 (1)
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