Snooze Control: Sleep Duration & Glucose Metabolism

Not Applicable

Completed

• Conditions: Glucose Metabolism Disorders
• Interventions: Behavioral: OGTT after deprived sleep first; Behavioral: OGTT after sufficient sleep first

• Registration Number: NCT02583750
• Lead Sponsor: Xuewen Wang

Brief Summary

This project investigated how glucose metabolism differs due to sleep deprivation for three consecutive nights as compared to sufficient sleep for three nights by examining concentrations of glucose, insulin, and other factors involved in glucose metabolism.

Detailed Description

16 participants were enrolled in the study (8 females, 8 males) aged 18-25 years. In order for the participants to qualify for the study, each had to wear a pedometer for a week before the study began to determine eligibility. Each participant came to the lab for an oral glucose tolerance test on a morning, following three nights when they were sleep deprived, and on another morning when they had three nights' sufficient sleep. The sequence of the oral glucose tolerance tests were randomly assigned. The sleep duration for participants was monitored by the readings of the sleep monitors that each participant wore. The oral glucose tolerance tests were performed after an overnight fast. A 20-gauge polyethylene catheter was placed in the antecubital vein for blood sampling. Blood samples were drawn once (0 min) before and 4 times (30, 60, 90, and 120 min) after a 75g glucose drink was consumed for the determination of plasma glucose, insulin, and concentrations of other factors. Each participant was told to continue their regular routine during the study period, including diet, caffeine usage, and exercise.

Study Timeline

• Study Start: 2014-01
• Primary Completion: 2014-08
• Study Completion: 2014-09
• Status Verified: 2015-10
• Study First Submitted: 2015-10-15
• Study First Submitted QC: 2015-10-20
• Last Update Submitted: 2015-10-20
• Study First Posted: 2015-10-22
• Last Update Posted: 2015-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• healthy college-aged males and females
• being minimally active

Exclusion Criteria

• average more than 15,000 steps a day
• major health issues such as heart disease, diabetes
• taking medication to help with sleep or using a sleeping device
• any type of sleep problem such as sleep apnea

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
OGTT after deprived sleep first	OGTT after deprived sleep first	Participants came to the lab to perform the oral glucose tolerance test after three nights of sleep deprivation, then another test after three nights of sufficient sleep
OGTT after sufficient sleep first	OGTT after sufficient sleep first	Participants came to the lab to perform the oral glucose tolerance test after three nights of sufficient sleep, then another test after three nights of deprived sleep

Primary Outcome Measures

Name	Time	Method
Glucose concentrations during oral glucose tolerance test	two hours

Trial Locations

Locations (1)

Public Health Research Center University of South Carolina; 🇺🇸 Columbia, South Carolina, United States