Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients

Phase 4

Completed

• Conditions: Ventilator Associated Pneumonia
• Interventions: Other: Common canister

• Registration Number: NCT01935388
• Lead Sponsor: Barnes-Jewish Hospital

Brief Summary

Many hospitals employ a common canister inhaler protocol in patients that do not require mechanical ventilator support. Common canister refers to a single inhaler paired with standardized cleaning methods for use on more than one patient. Small reports suggest that this method does not pose an increased infectious risk and is associated with significant cost savings.

Common canister protocols offer a solution to the discordance between inhaler sizes and average inpatient use of the drugs. Metered dose inhaler canisters are contain enough drug for several days to weeks of daily use. However, the average length of stay for most inpatients is only several days. Therefore, most inpatients do not use all of the canister contents, an unused resource that is potentially wasted.

The common canister approach has not been previously described in mechanically ventilated patients (people requiring intensive care unit admission on breathing machines). This study aims to assess the safety of common canister utilization by assessment and comparison of infection rates in the study and control group.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2013-07-31
• Study First Submitted QC: 2013-09-04
• Study First Posted: 2013-09-05
• Primary Completion: 2016-02
• Study Completion: 2016-03
• Status Verified: 2016-10
• Last Update Submitted: 2016-10-06
• Last Update Posted: 2016-10-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 354

Inclusion Criteria

• mechanically ventilated patients prescribed bronchodilator therapy in a medical intensive care unit

Exclusion Criteria

• lung transplant
• neutropenic
• contact isolation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Common canister	Common canister	Use of a single MDI (instead of assigning each patient an individual MDI) for multiple mechanically ventilated patients. Inhalers will undergo a stringent cleaning protocol between administrations and storage.

Primary Outcome Measures

Name	Time	Method
Ventilator-associated pneumonia (VAP)	48 hours after intubation	Pneumonia that developed in association with mechanical ventilation

Secondary Outcome Measures

Name	Time	Method
Inhaler drug cost	During period of mechanical ventilation, which varies depending on patient's severity of illness and reason for intubation; on average may range from 3-5 days.	Inhaler charges accrued during mechanical ventilation

Trial Locations

Locations (1)

Barnes-Jewish Hospital; 🇺🇸 Saint Louis, Missouri, United States