Interpersonal Psychotherapy for Adolescent Girls

Not Applicable

Completed

• Conditions: Depression
• Interventions: Behavioral: Enhanced Care; Behavioral: Interpersonal Psychotherapy for Adolescents

• Registration Number: NCT01534377
• Lead Sponsor: University of Rochester

Brief Summary

This study will evaluate the efficacy of Interpersonal Psychotherapy for Adolescents (IPT-A) for the treatment of depression and prevention of depression in maltreated and nonmaltreated girls between the ages of 13-15 years old.

Detailed Description

Child maltreatment poses a serious public health problem and heightens the risk of psychopathology across the life course. Adolescence also represents a peak time for the emergence of depressive disorders particularly in girls. Effective interventions to prevent and treat depression in low income adolescent girls with or without histories of maltreatment are needed.

Three groups will be recruited: Maltreated Depressive Symptoms (MDS), Nonmaltreated Depressive Symptoms (NDS), and a Nonmaltreated Nonsymptomatic Comparison (NNC), comparable in SES, race/ethnicity, and household composition. The MDS and NDS groups will be randomized into IPT-A or Enhanced Care (EC). Adolescent girls in these groups will receive 13 sessions of therapy. Girls in the NNC group will only complete research visits.

Research assessments will be conducted at T1 (baseline/prior to intervention), T2 (6-weeks mid-intervention), T3 (end of intervention), T4 (1-year post) and T5 (18 months post). Girls and their mothers will participate in these research sessions. A multi-level-of-analysis approach, integrating genotyping, hormone assays, cognitive testing, adolescent- and maternal-report, mother-teen observation, and DHS and school records will be utilized to assess the effectiveness of the interventions.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2011-07
• Study First Submitted: 2012-02-02
• Study First Submitted QC: 2012-02-13
• Study First Posted: 2012-02-16
• Primary Completion: 2018-06
• Study Completion: 2018-06
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-02
• Last Update Posted: 2018-08-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 328

Inclusion Criteria

• girls
• ages 13-15 years old
• low SES status
• live in Rochester or surrounding counties
• girls in the maltreated depressive symptom group will have CPS-documented child maltreatment
• girls in the nonmaltreated depressive symptom group will not have CPS- documented child maltreatment
• girls in the nonmaltreated nonsymptomatic comparison group will have no current or past mental illness and no documented child maltreatment

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Exclusion Criteria

• taking antidepressants or prescription medications for anxiety
• already receiving mental health treatment
• actively suicidal
• diagnosed with a severe mental disorder
• abusing drugs or alcohol
• evidence of compromised cognitive ability
• evidence of a pervasive developmental disorder
• evidence of a major physical or neurological disorder
• non-English speaking

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Enhanced Care	Enhanced Care	Adolescents will receive the Enhanced care model or care that they would typically receive in community setting to treat and prevent depression.
Interpersonal Psychotherapy	Interpersonal Psychotherapy for Adolescents	Adolescents will receive Interpersonal Psychotherapy for the treatment and prevention of depression.

Primary Outcome Measures

Name	Time	Method
Change in adolescent depressive symptoms from baseline to post-intervention	Baseline and 12 weeks, follow up at 1 year & again at 18 months post intervention	To evaluate the efficacy of Interpersonal Psychotherapy for Adolescents (IPT-A) for decreasing depressive symptoms and preventing depression in low-income ethnically and culturally diverse adolescent girls with and without histories of child maltreatment

Trial Locations

Locations (1)

Mt. Hope Family Center; 🇺🇸 Rochester, New York, United States