The effect of intraoperative replacement solutions with hydroxyethylstarch and lactated ringer on renal function in patients undergoing abdominal uterine removal surgery

Not Applicable

• Conditions: Healthy patients; female; intervention volunteers; changes in renal function; perioperative; E04.249; E01.370.390.400; E04.614

• Registration Number: RBR-7j75q5
• Lead Sponsor: Faculdade de Medicina de Botucatu - UNESP

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-07-09
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

Healthy volunteers; female; preserved renal function; open abdominal hysterectomy; general anesthesia;

Exclusion Criteria

Patient refusal; altered renal function; use of diuretics; obesity; decompensated hypertension; decompensated diabetes mellitus;

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate and compare the biomarkers dosage of renal function, measured by laboratory analysis in the preoperative period, on the 1st postoperative day and 40 days after surgery;;To compare intra and postoperative urinary output through bladder catheterization;;Relate changes of renal function biomarkers with intraoperative hemodynamic monitoring, through laboratory analysis and vital signs data during surgery;;To compare the times of anesthesia recovery and hospitalization, by concomitant follow-up of patients in the perioperative period;

Secondary Outcome Measures

Name	Time	Method
To compare the total infused volume of colloid and crystalloid solutions in the intraoperative period;;To compare the amount of blood loss, by quantification in vacuum cleaners and weight of compresses, and the need for intra and postoperative blood transfusions;;To compare the incidence of other postoperative complications;To compare the morbidity and mortality rates at 7 and 40 days after surgery.;Postoperative pain score based on Verbal Analog Scale;