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临床试验/CTRI/2025/04/084606
CTRI/2025/04/084606尚未招募Phase 3 4

Comparative evaluation of bacterial reduction at various stages of Endodontic Retreatment after the use of 2 percentage Chlorhexidine gel and modified triple antibiotic paste as Intracanal medicaments - A Non-Randomized Clinical Trial Study

Adithya Kashyap1 个研究点 分布在 1 个国家目标入组 26 人开始时间: 2025年4月20日最近更新:

试验速览

阶段
Phase 3 4
状态
尚未招募
发起方
入组人数
26
试验地点
1
主要终点
Reduced bacterial count after the use of 2% Chlorhexidine gel as well as after the use of modified triple antibiotic paste

研究概览

简要总结

Favorable outcome of non surgicalendodontic retreatment depends on the complete elimination of the microflorafrom the root canal system. But the conventional chemo-mechanical cleaning andshaping (i.e; using file system and irrigants) may not be successful enough toeliminate the flora and therefore needs the addition of suitable intracanalmedicament along with the conventional cleaning and shaping. The most commonly used Intracanal medicament is Calcium hydroxide, which is been used from a long time. But, Calcium hydroxide has several drawbacks such as: The high pH (11 to 12) might be toxic to the periapical gem cells, Inability/ resistance of many microorganisms against calcium hydroxide etc. Therefore, this necessitates the need for a better and more efficient intracanal medicament during retreatment procedures. The proposed studyis an interventional study which will be done to evaluate and compare the levelof  bacterial reduction between 2intracanal medicaments: 2% Chlorhexidine gel and modified triple antibioticpaste during non surgical endodontic retreatment. 26 participants will bedivided randomly into 2 study groups: group I will be getting 2% Chlorhexidinegel as the Intracanal medicament and group II will be getting freshly preparedmodified triple antibiotic paste. Three samples from each participants will becollected during various stages of the retreatment procedure and sent forcolony count calculation and evaluating the reduction in bacterial count.

研究设计

研究类型
Interventional
分配方式
Not Applicable
盲法
Not Applicable

入排标准

年龄范围
18.00 Year(s) 至 50.00 Year(s)(—)
性别
All

入选标准

  • 1- Single root filled teeth indicated for non surgical endodontic retreatment procedure as assessed with clinical and radiographical signs 2- root canal treatment completed more than 2years ago.

排除标准

  • 1- Patients with history of antibiotic treatment usage in the last 3 months 2- patients reporting with systemic disease starting with ASA grade 3 and above 3- teeth in which rubber dam application for isolation is not feasible 4- Teeth with periodontal pocket depth more than 3mm.

结局指标

主要结局

Reduced bacterial count after the use of 2% Chlorhexidine gel as well as after the use of modified triple antibiotic paste

时间窗: on 7th day

次要结局

  • Comparation between 2% chlorhexidine gel and modified triple antibiotic paste(7th day)

研究者

发起方
Adithya Kashyap
申办方类型
Other [self]

研究点 (1)

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