Evaluating the level of bacterial reduction during re root canal treatment after the use of 2 percentage Chlorhexidine and modified triple antibiotic paste as root canal medicament

Phase 3

Not yet recruiting

Conditions: Diseases of pulp and periapical tissues,

Registration Number: CTRI/2025/04/084606

Lead Sponsor: Adithya Kashyap

Brief Summary: Favorable outcome of non surgicalendodontic retreatment depends on the complete elimination of the microflorafrom the root canal system. But the conventional chemo-mechanical cleaning andshaping (i.e; using file system and irrigants) may not be successful enough toeliminate the flora and therefore needs the addition of suitable intracanalmedicament along with the conventional cleaning and shaping. The most commonly used Intracanal medicament is Calcium hydroxide, which is been used from a long time. But, Calcium hydroxide has several drawbacks such as: The high pH (11 to 12) might be toxic to the periapical gem cells, Inability/ resistance of many microorganisms against calcium hydroxide etc. Therefore, this necessitates the need for a better and more efficient intracanal medicament during retreatment procedures. The proposed studyis an interventional study which will be done to evaluate and compare the levelof bacterial reduction between 2intracanal medicaments: 2% Chlorhexidine gel and modified triple antibioticpaste during non surgical endodontic retreatment. 26 participants will bedivided randomly into 2 study groups: group I will be getting 2% Chlorhexidinegel as the Intracanal medicament and group II will be getting freshly preparedmodified triple antibiotic paste. Three samples from each participants will becollected during various stages of the retreatment procedure and sent forcolony count calculation and evaluating the reduction in bacterial count.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 26

Inclusion Criteria

1- Single root filled teeth indicated for non surgical endodontic retreatment procedure as assessed with clinical and radiographical signs 2- root canal treatment completed more than 2years ago.

Exclusion Criteria

1- Patients with history of antibiotic treatment usage in the last 3 months 2- patients reporting with systemic disease starting with ASA grade 3 and above 3- teeth in which rubber dam application for isolation is not feasible 4- Teeth with periodontal pocket depth more than 3mm.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduced bacterial count after the use of 2% Chlorhexidine gel as well as after the use of modified triple antibiotic paste	on 7th day

Secondary Outcome Measures

Name	Time	Method
Comparation between 2% chlorhexidine gel and modified triple antibiotic paste	7th day

Trial Locations

Locations (1): Yenepoya Dental College
🇮🇳
Kannada, KARNATAKA, India
Yenepoya Dental College
🇮🇳Kannada, KARNATAKA, India
Dr Adithya Kashyap
Principal investigator
9108276520
adithyaanu1998@gmail.com