Advanced MR Neuroimaging in presenile dementia

Recruiting

• Conditions: neurodegeneratieve aandoeningen; dementia; MRI; 10042258

• Registration Number: NL-OMON35133
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

- Young (<65 years) patients presenting to the memory clinic at Erasmus MC
- Suspected diagnosis of AD or FTD
- Mild dementia (clinical dementia rating scale <=1)

Exclusion Criteria

- Contraindications for MRI scanning
- Inability to comprehend fMRI tasks
- Other causes of dementia (eg, vascular, alcohol, etcetera)
- Use of vasoactive or psychoactive medication

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>§ White and grey matter volumes.<br /><br>§ White matter integrity: mean diffusivity (MD) and fractional anisotropy (FA)<br /><br>maps.<br /><br>§ Brain function: extent of fMRI activation (number and spatial distribution of<br /><br>significantly activated voxels).<br /><br>§ Quantitative brain perfusion maps.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>na</p><br>